Results 21 to 30 of about 14,528 (201)
Frontiers in Microbiology, 2020 (p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha +3 more
doaj +1 more source
Frontiers in Microbiology, 2020 The molecule guanosine tetraphophosphate (ppGpp) is most commonly considered an alarmone produced during acute stress. However, ppGpp is also present at low concentrations during steady-state growth.
Nicole C. E. Imholz +3 more
doaj +1 more source
Roles of transcriptional and translational control mechanisms in regulation of ribosomal protein synthesis in Escherichia coli [PDF]
, 2017 Bacterial ribosome biogenesis is tightly regulated to match nutritional conditions and to prevent formation of defective ribosomal particles. InEscherichia coli, most ribosomal protein (r-protein) synthesis is coordinated with rRNA synthesis by a ...
Burgos, Hector L +3 more
core +3 more sources
Synthetic (p)ppGpp analogue is an inhibitor of stringent response in mycobacteria [PDF]
, 2017 Bacteria elicit an adaptive response against hostile conditions such as starvation and other kinds of stresses. Their ability to survive such conditions depends, in part, on stringent response pathways.
Bhardwaj, Neerupma +6 more
core +2 more sources
Transcriptional Responses to ppGpp and DksA [PDF]
Annual Review of Microbiology, 2018 The stringent response to nutrient deprivation is a stress response found throughout the bacterial domain of life. Although first described in proteobacteria for matching ribosome synthesis to the cell's translation status and for preventing formation of defective ribosomal particles, the response is actually much broader, regulating many hundreds of ...
Richard L, Gourse +5 more
openaire +2 more sources
The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly
Cells, 2019 Many facets of ribosome biogenesis and function, including ribosomal RNA (rRNA) transcription, 70S assembly and protein translation, are negatively impacted upon induction of a nutrient stress-sensing signalling pathway termed the stringent response ...
Daniel J. Bennison +2 more
doaj +1 more source
Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment. [PDF]
, 2017 Upon entry into the host cell cytosol, the facultative intracellular pathogen Listeria monocytogenes coordinates the expression of numerous essential virulence factors by allosteric binding of glutathione (GSH) to the Crp-Fnr family transcriptional ...
Aaron T. Whiteley +5 more
core +2 more sources
Frontiers in Microbiology, 2020 The stringent response is characterized by the synthesis of the alarmone (p)ppGpp. The phenotypic consequences resulting from (p)ppGpp accumulation vary among species, and for several pathogenic bacteria, it has been shown that the activation of the ...
Andrea Salzer +4 more
doaj +1 more source
An Interplay among FIS, H-NS, and Guanosine Tetraphosphate Modulates Transcription of the Escherichia coli cspA Gene under Physiological Growth Conditions [PDF]
, 2016 CspA, the most characterized member of the csp gene family of Escherichia coli, is highly expressed not only in response to cold stress, but also during the early phase of growth at 37°C.
Anna Brandi +3 more
core +11 more sources
Novel (p)ppGpp Binding and Metabolizing Proteins of
mBio, 2018 The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics.
Yong Zhang +3 more
doaj +1 more source