Results 31 to 40 of about 14,528 (201)

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.

PLoS Pathogens, 2021
Bacteria inhabit diverse environmental niches and consequently must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p ...
N Y Elizabeth Chau, Shehryar Ahmad, John C Whitney, Brian K Coombes   +3 more
doaj   +1 more source

The transcription factor DksA exerts opposing effects on cell division depending on the presence of ppGpp

mBio, 2023
Bacterial cell size is a multifactorial trait that is influenced by variables including nutritional availability and the timing of cell division. Prior work revealed a negative correlation between concentration of the alarmone (p)ppGpp (ppGpp) and cell ...
Sarah E. Anderson, Stephen E. Vadia, Jane McKelvy, Petra Anne Levin   +3 more
doaj   +1 more source

EcoCyc: fusing model organism databases with systems biology. [PDF]

, 2012
EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E.
Bonavides-Martínez, César, Collado-Vides, Julio, Fulcher, Carol, Gama-Castro, Socorro, Gunsalus, Robert P, Huerta, Araceli M, Karp, Peter D, Keseler, Ingrid M, Kothari, Anamika, Krummenacker, Markus, Latendresse, Mario, Mackie, Amanda, Muñiz-Rascado, Luis, Ong, Quang, Paley, Suzanne, Paulsen, Ian, Peralta-Gil, Martin, Santos-Zavaleta, Alberto, Schröder, Imke, Shearer, Alexander G, Subhraveti, Pallavi, Travers, Mike, Weerasinghe, Deepika, Weiss, Verena   +23 more
core   +1 more source

The Role of RelA and SpoT on ppGpp Production, Stress Response, Growth Regulation, and Pathogenicity in Xanthomonas campestris pv. campestris

Microbiology Spectrum, 2021
The alarmone ppGpp plays an important role in the survival of bacteria by triggering the stringent response when exposed to environmental stress. Although Xanthomonas campestris pv.
Kaihong Bai, Huayu Yan, Xing Chen, Qingyang Lyu, Na Jiang, Jianqiang Li, Laixin Luo   +6 more
doaj   +1 more source

Structural and Functional Analysis of BipA, a Regulator of Virulence in Enteropathogenic Escherichia coli. [PDF]

, 2015
The translational GTPase BipA regulates the expression of virulence and pathogenicity factors in several eubacteria. BipA-dependent expression of virulence factors occurs under starvation conditions, such as encountered during infection of a host.
Blaha, Gregor, Diggs, Stephen, Fan, Haitian, Hahm, Joseph, Perry, J Jefferson P   +4 more
core   +2 more sources

(p)ppGpp: Magic Modulators of Bacterial Physiology and Metabolism

Frontiers in Microbiology, 2020
When bacteria experience growth-limiting environmental conditions, the synthesis of the hyperphosphorylated guanosine derivatives (p)ppGpp is induced by enzymes of the RelA/SpoT homology (RSH)-type protein family. High levels of (p)ppGpp induce a process
Wieland Steinchen, Victor Zegarra, Gert Bange   +2 more
doaj   +1 more source

Regulation of ytfK by cAMP-CRP Contributes to SpoT-Dependent Accumulation of (p)ppGpp in Response to Carbon Starvation YtfK Responds to Glucose Exhaustion

Frontiers in Microbiology, 2021
Guanosine penta- or tetraphosphate (known as (p)ppGpp) serves as second messenger to respond to nutrient downshift and other environmental stresses, a phenomenon called stringent response.
Laura Meyer, Elsa Germain, Etienne Maisonneuve   +2 more
doaj   +1 more source

Diversity in (p)ppGpp metabolism and effectors [PDF]

Current Opinion in Microbiology, 2015
Bacteria produce guanosine tetraphosphate and pentaphosphate, collectively named (p)ppGpp, in response to a variety of environmental stimuli. These two remarkable molecules regulate many cellular processes, including the central dogma processes and metabolism, to ensure survival and adaptation.
Kuanqing Liu, Alycia N Bittner, Jue D Wang   +2 more
openaire   +2 more sources

Monitoring of nutrient limitation in growing E. coli: A mathematical model of a ppGpp-based biosensor [PDF]

, 2017
Background: E. coli can be used as bacterial cell factories for production of biofuels and other useful compounds. The efficient production of the desired products requires careful monitoring of growth conditions and the optimization of metabolic ...
Pokhilko, Alexandra
core   +3 more sources

SlyA Transcriptional Regulator Is Not Directly Affected by ppGpp Levels

Frontiers in Microbiology, 2020
The SlyA transcriptional regulator controls the expression of genes involved in virulence and production of surface components in S. Typhimurium and E. coli.
Julia Bartoli, Julie Pamela Viala, Emmanuelle Bouveret   +2 more
doaj   +1 more source