Results 41 to 50 of about 14,528 (201)

Possible Roles for Basal Levels of (p)ppGpp: Growth Efficiency Vs. Surviving Stress

Frontiers in Microbiology, 2020
Two (p)ppGpp nucleotide analogs, sometimes abbreviated simply as ppGpp, are widespread in bacteria and plants. Their name alarmone reflects a view of their function as intracellular hormone-like protective alarms that can increase a 100-fold when sensing
Llorenç Fernández-Coll, Michael Cashel
doaj   +1 more source

Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase. [PDF]

Mol Microbiol
COL is an unusual “model” strain of Staphylococcus aureus that exhibits slow growth and multidrug antibiotic tolerance. This phenotype is primarily due to a mutation in Prs, which synthesizes the core metabolite phosphoribosyl pyrophosphate (PRPP). Introduction of the COL Prs allele into the antibiotic‐susceptible strain Newman confers tolerance, while
Stevens CE, Deventer AT, Johnston PR, Lowe PT, Boraston AB, Hobbs JK.   +5 more
europepmc   +2 more sources

Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation in Pseudomonas aeruginosa [PDF]

, 2017
Polyphosphate (polyP) granule biogenesis is an ancient and ubiquitous starvation response in bacteria. Although the ability to make polyP is important for survival during quiescence and resistance to diverse environmental stresses, granule genesis is ...
Dieterle, Michael G., Jensen, Grant J., Newman, Dianne K., Racki, Lisa R., Sullivan, Meaghan C., Tocheva, Elitza I.   +5 more
core   +1 more source

Robust Detection of Hierarchical Communities from Escherichia coli Gene Expression Data [PDF]

, 2012
Determining the functional structure of biological networks is a central goal of systems biology. One approach is to analyze gene expression data to infer a network of gene interactions on the basis of their correlated responses to environmental and ...
A Beyer, AL Barabási, BH Good, BW Kernighan, CO Daub, D Duewer, D Marbach, DFT Veiga, E Bonnet, E Ravasz, E Segal, EH Davidson, F Luo, G Balázsi, G Getz, G Palla, G Palla, H Zare, HW Ma, J Chen, J Duch, J Hubble, J Lemke, J Reichardt, JJ Faith, JJ Faith, JN Weinstein, K Baggerly, Kevin E. Bassler, KY Yeung, M Blatt, M Riley, MB Eisen, MEJ Newman, MEJ Newman, MF Traxler, MM Barker, N Friedman, N Friedman, O Alter, PD Karp, Q Lu, R Guimerà, RA Irizarry, S Fortunato, S Fortunato, S Gama-Castro, S Raychaudhuri, S Tavazoie, Santiago Treviño, Satoru Miyano, SB Seidman, SB Seidman, SP Borgatii, SP Borgatii, TF Cooper, Tim F. Cooper, TS Gardner, U Brandes, UN Raghavan, X Wen, Y Benjamini, Y Sun, Yudong Sun, Z Shi   +64 more
core   +13 more sources

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

eLife, 2019
The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with its ...
Brent W Anderson, Kuanqing Liu, Christine Wolak, Katarzyna Dubiel, Fukang She, Kenneth A Satyshur, James L Keck, Jue D Wang   +7 more
doaj   +1 more source

Diversity in E. coli (p)ppGpp Levels and Its Consequences

Frontiers in Microbiology, 2020
(p)ppGpp is at the core of global bacterial regulation as it controls growth, the most important aspect of life. It would therefore be expected that at least across a species the intrinsic (basal) levels of (p)ppGpp would be reasonably constant.
Beny Spira, Katia Ospino
doaj   +1 more source

Basal level of ppGpp coordinates Escherichia coli cell heterogeneity and ampicillin resistance and persistence

Microbial Cell, 2023
The universal stringent response alarmone ppGpp (guanosine penta and tetra phosphates) plays a crucial role in various aspects of fundamental cell physiology (e.g., cell growth rate, cell size) and thus bacterial tolerance to and survival of external ...
Paulina Katarzyna Grucela, Yong Everett Zhang   +1 more
doaj   +1 more source

Effects of (p)ppGpp on the progression of the cell cycle of Caulobacter crescentus. [PDF]

, 2014
Bacteria must control the progression of their cell cycle in response to nutrient availability. This regulation can be mediated by guanosine tetra- or pentaphosphate [(p)ppGpp], which are synthesized by enzymes of the RelA/SpoT homologue (Rsh) family ...
Collier, J., Gonzalez, D.
core   +1 more source

ppGpp functions as an alarmone in metazoa [PDF]

Communications Biology, 2019
AbstractGuanosine 3’,5’-bis(pyrophosphate) (ppGpp) functions as a second messenger in bacteria to adjust their physiology in response to environmental changes. In recent years, the ppGpp-specific hydrolase, metazoan SpoT homolog-1 (Mesh1), was shown to have important roles for growth under nutrient deficiency inDrosophila melanogaster.
Doshun Ito, Hinata Kawamura, Akira Oikawa, Yuta Ihara, Toshio Shibata, Nobuhiro Nakamura, Tsunaki Asano, Shun-Ichiro Kawabata, Takashi Suzuki, Shinji Masuda   +9 more
openaire   +2 more sources

Rapid curtailing of the stringent response by toxin-antitoxin module-encoded mRNases [PDF]

, 2016
Escherichia coli regulates its metabolism to adapt to changes in the environment, in particular to stressful downshifts in nutrient quality. Such shifts elicit the so-called stringent response, coordinated by the alarmone guanosine tetra- and ...
Tian, Chengzhe, Roghanian, Mohammed, Jørgensen, Mikkel Girke, Sneppen, Kim, Sørensen, Michael Askvad, Gerdes, Kenn, Mitarai, Namiko   +6 more
core   +3 more sources