Results 61 to 70 of about 14,528 (201)

The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC

mBio, 2019
The stringent response enables bacteria to respond to a variety of environmental stresses, especially various forms of nutrient limitation. During the stringent response, the cell produces large quantities of the nucleotide alarmone ppGpp, which ...
James A. Kraemer, Allen G. Sanderlin, Michael T. Laub   +2 more
doaj   +1 more source

Cross-talk between two nucleotide-signaling pathways in Staphylococcus aureus. [PDF]

, 2014
Nucleotide-signaling pathways are found in all kingdoms of life and are utilized to coordinate a rapid response to external stimuli. The stringent response alarmones guanosine tetra- (ppGpp) and pentaphosphate (pppGpp) control a global response allowing ...
Alexandra R. Willis, An, Angelika Gründling, Bae, Bai, Bai, Battesti, Boles, Cashel, Cashel, Charpentier, Corrigan, Corrigan, Corrigan, Cosgrove, Dalebroux, Fiil, Fong, French, Gao, Gao, Geiger, Geiger, Geiger, Gentry, Glass, Griffiths, Gründling, Hanahan, Herbert, Horsburgh, Knutsson Jenvert, Lee, Lemos, Lisa Bowman, Lu, Lund, Luo, L̸eski, Maisonneuve, McDonough, Mehne, Memmi, Miller, Mwangi, Nagarajan, Nanamiya, Nelson, Nguyen, Ochi, Potrykus, Pozzi, Rallu, Rao, Rebecca M. Corrigan, Roelofs, Rudin, Römling, Smith, Song, Sureka, Thomaides, Volkhard Kaever, Webb, Witney, Witte, Woodward   +66 more
core   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Direct detection of stringent alarmones (pp)pGpp using malachite green

Microbial Cell
The alarmone (p)ppGpp serves as the signalling molecule for the bacterial universal stringent response and plays a crucial role in bacterial virulence, persistence, and stress adaptation. Consequently, there is a significant focus on developing new drugs
Muriel Schicketanz, Magdalena Petrová, Dominik Rejman, Margherita Sosio, Stefano Donadio, Yong Everett Zhang   +5 more
doaj   +1 more source

Basal Levels of (p)ppGpp in Enterococcus faecalis: the Magic beyond the Stringent Response

mBio, 2013
The stringent response (SR), mediated by the alarmone (p)ppGpp, is a conserved bacterial adaptation system controlling broad metabolic alterations necessary for survival under adverse conditions.
Anthony O. Gaca, Jessica K. Kajfasz, James H. Miller, Kuanqing Liu, Jue D. Wang, Jacqueline Abranches, José A. Lemos   +6 more
doaj   +1 more source

Survival of the Fittest: The Relationship of (p)ppGpp With Bacterial Virulence

Frontiers in Microbiology, 2020
The signaling nucleotide (p)ppGpp has been the subject of intense research in the past two decades. Initially discovered as the effector molecule of the stringent response, a bacterial stress response that reprograms cell physiology during amino acid ...
Shivani Kundra, Cristina Colomer-Winter, José A. Lemos   +2 more
doaj   +1 more source

Two (p)ppGpp Synthetase Genes, relA and spoT, Are Involved in Regulating Cell Motility, Exopolysaccharides Production, and Biofilm Formation of Vibrio alginolyticus

Frontiers in Microbiology, 2022
The stringent response mediated by the signal molecule (p)ppGpp is involved in response to multiple environmental stresses and control of various physiological processes.
Wen-Liang Yin, Wen-Liang Yin, Wen-Liang Yin, Zhen-Yu Xie, Zhen-Yu Xie, Zhen-Yu Xie, Zhen-Yu Xie, Yan-Hua Zeng, Yan-Hua Zeng, Ju Zhang, Ju Zhang, Ju Zhang, Hao Long, Hao Long, Wei Ren, Wei Ren, Wei Ren, Wei Ren, Xiang Zhang, Xiang Zhang, Xiang Zhang, Xiang Zhang, Xiao-Ni Cai, Xiao-Ni Cai, Xiao-Ni Cai, Xiao-Ni Cai, Ai-You Huang, Ai-You Huang, Ai-You Huang, Ai-You Huang   +29 more
doaj   +1 more source

Evolution of a genome-encoded bias in amino acid biosynthetic pathways is a potential indicator of amino acid dynamics in the environment. [PDF]

, 2014
Overcoming the stress of starvation is one of an organism's most challenging phenotypic responses. Those organisms that frequently survive the challenge, by virtue of their fitness, will have evolved genomes that are shaped by their specific environments.
Fasani, Rick A, Savageau, Michael A
core   +1 more source

Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments

Water and Environment Journal, EarlyView.
Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze, Musa Marimani, Katlego Mamabolo, Mrudula Patel   +3 more
wiley   +1 more source

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria [PDF]

, 2016
The stringent response is a survival mechanism used by bacteria to deal with stress. It is coordinated by the nucleotides guanosine tetraphosphate and pentaphosphate [(p)ppGpp], which interact with target proteins to promote bacterial survival.
Bellows, L.E., Corrigan, R., Grundling, A., Wood, A.   +3 more
core   +1 more source