Development of a Virtual Screening Pipeline for the Identification of Small Molecule PPIP5K2 Inhibitors [PDF]
, 2021 Phosphate homeostasis is essential for survival in eucaryotes. It is mediated by inositol phosphates, which are synthesized by a sequence of kinases. One such kinase in humans is diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2).
Leja, Mareike
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Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis [PDF]
, 2018 Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to ...
Alcazar-Roman +104 more
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The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis [PDF]
, 2021 Initial studies on the inositol phosphates metabolism were enabled by the social amoeba Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP6 also known as Phytic acid) present in the amoeba allowed the discovery of the more ...
Borghi, F +8 more
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Identification and characterization of evolutionarily conserved inositol pyrophosphate phosphohydrolases in plants [PDF]
, 2023 Inositol phosphates (InsPs), phosphate esters of myo-inositol, are cellular regulators with critical roles in a wide range of cellular processes in eukaryotes.
Gaugler, Philipp
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Genetic analysis of cell cycle and chromatin regulation in quiescent fission yeast cells [PDF]
, 2022 During proliferation, cells produce their genetic materials to increase the number of cells, while in the absence of nutrients or by the induction of stimulus, the proliferative phase is stopped and entry into quiescence is triggered to increase their ...
Zahedi, Yasaman
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The Asp1 pyrophosphatase from S. pombe hosts a [2Fe-2S]2+ cluster in vivo [PDF]
, 2021 The Schizosaccharomyces pombe Asp1 protein is a bifunctional kinase/pyrophosphatase that belongs to the highly conserved eukaryotic diphosphoinositol pentakisphosphate kinase PPIP5K/Vip1 family.
Birrell, James A +7 more
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The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in S. pombe [PDF]
, 2021 Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by phosphoanhydride bonds.
Fleig, U +3 more
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INOSITOL (1,3,4) TRIPHOSPHATE 5/6 KINASE1-Dependent Inositol Polyphosphates Regulate Auxin Responses in Arabidopsis [PDF]
, 2022 The combinatorial phosphorylation of myo-inositol results in the generation of different inositol phosphates (InsPs), of which phytic acid (InsP6) is the most abundant species in eukaryotes.
Bhattacharjee, Saikat +18 more
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Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease [PDF]
, 2016 Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders ...
Bruni, AC +6 more
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Cellular Functions of myo-Inositol-Derived Signaling Molecules in Yeast and Plants during Abiotic and Biotic Stresses [PDF]
, 2021 Myo-Inositol (Ins)-derived molecules are involved in many cellular processes. Besides the role as compatible solute, Ins represents the building block for a variety of molecules, which function as signaling molecules. Cells utilize insoluble (lipid-bound)
Johnen, Philipp
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