Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease [PDF]
, 2016 Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders ...
Bruni, AC +6 more
core +1 more source
PPIP5K1 Suppresses Etoposide-triggered Apoptosis
Journal of Molecular Signaling, 2016 Inositol hexakisphosphate kinase 2 (IP6K2) potentiates pro-apoptotic signalling and increases the sensitivity of mammalian cells to cytotoxic agents. Diphosphoinositol pentakisphosphate kinase (PPIP5K) generates inositol pyrophosphates (InsPPs) that are ...
Gayane Machkalyan +2 more
semanticscholar +1 more source
bioRxiv, 2019 Background Inositol pyrophosphates (PP-InsPs) are high-energy cellular molecules involved in different signalling and regulatory responses. Two distinct classes of inositol phosphate kinases responsible for the synthesis of PP-InsPs have been identified ...
Anuj Shukla +12 more
semanticscholar +1 more source
First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase [PDF]
, 2012 We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP5 mimics 5-PP-InsP 5 binding to the kinase domain of PPIP5K2;
Potter, BVL +4 more
core +2 more sources
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4 [PDF]
, 2023 Myo-inositol tris/tetrakisphosphate kinases (ITPKs) catalyze diverse phosphotransfer reactions with myo-inositol phosphate and myo-inositol pyrophosphate substrates. However, the lack of structures of nucleotide-coordinated plant ITPKs thwarts a rational
Brearley, Charles A. +9 more
core +1 more source
PLoS ONE, 2017 The authors of the above paper retract this article due to concerns about the integrity of the data and the validity of the conclusions. The first author, Brandi M. Baughman, has admitted to the co-authors and the Office of Research Integrity at NIH that
Brandi M Baughman +8 more
semanticscholar +1 more source
Chemical tools to investigate inositol pyrophosphate protein interactions [PDF]
, 2023 Die Inositol-Pyrophosphate (PP-InsPs) sind eine ubiquitäre Gruppe hochphosphorylierter eukaryotischer Signalmoleküle. Sie werden mit einer Vielzahl zentraler zellulärer Prozesse in Verbindung gebracht, doch fehlt oft ein detailliertes Verständnis der ...
Furkert, David
core +1 more source
Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry [PDF]
, 2020 The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to the large number of possible isomers, the absence of a chromophore, the high charge density, the low abundance, and the instability ...
Eisenbeis, VB +14 more
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Synthetic tools for studying the chemical biology of InsP8 [PDF]
, 2015 To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups.
Potter, Barry V L +3 more
core +3 more sources
Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling [PDF]
, 2017 Inositol polyphosphates, in their water-soluble or lipid-bound forms, represent a large and multifaceted family of signalling molecules. Some inositol polyphosphates are well recognised as defining important signal transduction pathways, as in the case ...
Saiardi, A, Wilson, MSC
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