Evaluation of low dose prazosin for PTSD-associated nightmares in children and adolescents [PDF]
Mental Health Clinician, 2023 Introduction: Knowledge about fundamental sleep disorders and dysregulation that occurs in children with PTSD is limited. Prazosin is an alpha-1 receptor antagonist often used off label for the treatment of PTSD-associated nightmares in adults; however ...
Nancy Hudson, PharmD +3 more
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Effects of chronic prazosin, an alpha-1 adrenergic antagonist, on anxiety-like behavior and cortisol levels in a chronic unpredictable stress model in zebrafish (Danio rerio) [PDF]
PeerJ, 2020 Post-traumatic stress disorder (PTSD) is often associated with significant neuroendocrine dysfunction and a variety of other symptoms. Today, there are limited efficacious treatment options for PTSD, none of which directly target the dysfunction observed
Michael P. O’Daniel +1 more
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The Discovery of α-Adrenoceptor Antagonists as a Potential New Treatment Option for Uveal Melanoma [PDF]
BiomoleculesUveal melanoma (UM) is the most common primary intraocular tumor in adults. Because of its high potential for spreading and its limited response to treatment, UM remains a clinical challenge. Previous studies suggest that clinical adrenergic receptor (AR)
Yilan He +5 more
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Asian Journal of Medical Sciences, 2015 Introduction: Scorpion sting is a major public health problem in India with severe life threatening complications. Toxin can cause autonomic overstimulation leading to hypertension, arrhythmias and pulmonary edema with left ventricular dysfunction ...
L Venugopal
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NeuroImage: Clinical, 2020 Background: Higher levels of anxiety, negative affect, and impaired emotion regulation are associated with alcohol use disorder (AUD) and contribute to relapse and worse treatment outcomes.
Claire E. Wilcox +8 more
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α1 Adrenergic Receptors Mediate Panic-like Defensive Behavior in Alcohol-Drinking but Not Alcohol-Naïve Rats [PDF]
PharmaceuticalsBackground: Most animals display different defensive behavioral strategies during imminent or potential threats. These responses are relevant for understanding human behavioral disorders.
Thatiane De Oliveira Sergio +3 more
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A sex-sensitive LC-MS/MS method with isotopic internal standard for prazosin bioequivalence: bridging precision medicine and generic drug policy in China [PDF]
Frontiers in PharmacologyObjectiveTo develop a rapid, sensitive, and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for prazosin quantification in human plasma, validate its application in bioequivalence studies, and investigate sex-specific ...
Hui Chen +6 more
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Doxazosin Immediate Release as a Novel Treatment for Nightmares in Posttraumatic Stress Disorder [PDF]
Case Reports in PsychiatryNightmares and flashbacks are common debilitating symptoms of posttraumatic stress disorder (PTSD) that can disrupt daily functioning. Prazosin, an alpha-1 adrenergic antagonist, has been commonly used off-label for the treatment of these intrusion ...
Danyaal Khan +2 more
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Prazosin dosed 3 times a day to treat flashbacks related to PTSD: A case report [PDF]
Mental Health Clinician, 2023 Prazosin is an alpha-1 adrenergic receptor antagonist widely known by mental health providers for its off-label use for nightmares in patients with PTSD.
Christie Richardson, DO, MS +2 more
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Frontiers in Psychiatry, 2022 Psychological trauma in childhood can lead to post-traumatic disorder (PTSD) with protracted comorbid depression, which responds poorly to conventional antidepressants.
Ping Guo +7 more
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