Tissue compatibility of poly (hydroxypropyl glutamate)-prazosin conjugates [PDF]
, 1992 Biocompatibility of an injectable biodegradable drug delivery system for prazosin was investigated in Sprague-Dawley rats by histological studies after subcutaneous injection ofpoly(hydroxypropyl glutamate)-prazosin (PHPG-prazosin) conjugate particles ...
Lia Xiaoling +4 more
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The Discovery of α-Adrenoceptor Antagonists as a Potential New Treatment Option for Uveal Melanoma [PDF]
BiomoleculesUveal melanoma (UM) is the most common primary intraocular tumor in adults. Because of its high potential for spreading and its limited response to treatment, UM remains a clinical challenge. Previous studies suggest that clinical adrenergic receptor (AR)
Yilan He +5 more
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Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter [PDF]
Frontiers in Pharmacology, 2015 The SLC22A1 influx transporter is expressed on the basolateral membrane of hepatocytes and is involved in the excretion of numerous cations. Inhibition of SLC22A1 by several antiretrovirals, such as the protease inhibitor darunavir, has not previously ...
Darren eMoss +3 more
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α1 Adrenergic Receptors Mediate Panic-like Defensive Behavior in Alcohol-Drinking but Not Alcohol-Naïve Rats [PDF]
PharmaceuticalsBackground: Most animals display different defensive behavioral strategies during imminent or potential threats. These responses are relevant for understanding human behavioral disorders.
Thatiane De Oliveira Sergio +3 more
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A sex-sensitive LC-MS/MS method with isotopic internal standard for prazosin bioequivalence: bridging precision medicine and generic drug policy in China [PDF]
Frontiers in PharmacologyObjectiveTo develop a rapid, sensitive, and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for prazosin quantification in human plasma, validate its application in bioequivalence studies, and investigate sex-specific ...
Hui Chen +6 more
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Prazosin dosed 3 times a day to treat flashbacks related to PTSD: A case report [PDF]
Mental Health Clinician, 2023 Prazosin is an alpha-1 adrenergic receptor antagonist widely known by mental health providers for its off-label use for nightmares in patients with PTSD.
Christie Richardson, DO, MS +2 more
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Evaluation of low dose prazosin for PTSD-associated nightmares in children and adolescents [PDF]
Mental Health Clinician, 2023 Introduction: Knowledge about fundamental sleep disorders and dysregulation that occurs in children with PTSD is limited. Prazosin is an alpha-1 receptor antagonist often used off label for the treatment of PTSD-associated nightmares in adults; however ...
Nancy Hudson, PharmD +3 more
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Doxazosin Immediate Release as a Novel Treatment for Nightmares in Posttraumatic Stress Disorder [PDF]
Case Reports in PsychiatryNightmares and flashbacks are common debilitating symptoms of posttraumatic stress disorder (PTSD) that can disrupt daily functioning. Prazosin, an alpha-1 adrenergic antagonist, has been commonly used off-label for the treatment of these intrusion ...
Danyaal Khan +2 more
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Frontiers in Psychiatry, 2022 Psychological trauma in childhood can lead to post-traumatic disorder (PTSD) with protracted comorbid depression, which responds poorly to conventional antidepressants.
Ping Guo +7 more
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Chronic Stress, 2021 Background The α 1 -adrenoreceptor antagonist prazosin has in many but not all studies been found to be effective for PTSD associated nightmares, hyperarousal symptoms, and total symptom severity.
Rebecca C. Hendrickson +4 more
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