Results 11 to 20 of about 12,167 (210)

Prazosin for the management of behavioural and psychological symptoms of dementia

Drugs in Context, 2022
Prazosin, a centrally acting α1 adrenoceptor antagonist, has been included in two published algorithms amongst the list of medications that may be used in the management of behavioural and psychological symptoms of dementia (BPSD).
Rajesh R Tampi, Deena J Tampi, Syeda Arshiya Farheen, Mahwish Adnan, Dhweeja Dasarathy   +4 more
doaj   +1 more source

The Relative Effects of Prazosin on Individual PTSD Symptoms: Evidence for Pathophysiologically-Related Clustering

Chronic Stress, 2021
Background The α 1 -adrenoreceptor antagonist prazosin has in many but not all studies been found to be effective for PTSD associated nightmares, hyperarousal symptoms, and total symptom severity.
Rebecca C. Hendrickson, Steven P. Millard, Kathleen F. Pagulayan, Elaine R. Peskind, Murray A. Raskind   +4 more
doaj   +1 more source

Muting Bacterial Communication: Evaluation of Prazosin Anti-Quorum Sensing Activities against Gram-Negative Bacteria Pseudomonas aeruginosa, Proteus mirabilis, and Serratia marcescens

Biology, 2022
Quorum sensing (QS) controls the production of several bacterial virulence factors. There is accumulative evidence to support that targeting QS can ensure a significant diminishing of bacterial virulence.
Abrar K. Thabit, Khalid Eljaaly, Ayat Zawawi, Tarek S. Ibrahim, Ahmed G. Eissa, Samar S. Elbaramawi, Wael A. H. Hegazy, Mahmoud A. Elfaky   +7 more
doaj   +1 more source

Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats

Pharmacology Research & Perspectives, 2022
The relationship between cardiovascular diseases and iron disorders has gained increasing attention; however, the effects of hypotensive drugs on iron metabolic alterations in hypertension are not well understood.
Hengrui Chang, Dong Zhang, Zhen Xin, Pengfei Zhang, Wenyuan Ding, Yan‐Zhong Chang   +5 more
doaj   +1 more source

The efficacy of administration of prazosin in reducing the risk of recurrent urethral obstruction in male cats

Veterinary Evidence, 2023
PICO Question In male cats presenting with urethral obstruction, does administration of prazosin compared with no administration of prazosin reduce the incidence of recurrent urethral obstruction within the first month of initial presentation ...
Rebecca Hearne
doaj   +1 more source

Controlling of Bacterial Virulence: Evaluation of Anti-Virulence Activities of Prazosin against Salmonella enterica

Antibiotics, 2022
Salmonella enterica is a Gram-negative orofecal transmitted pathogen that causes a wide diversity of local and systemic illnesses. Salmonella enterica utilizes several interplayed systems to regulate its invasion and pathogenesis: namely, quorum sensing (
Mahmoud A. Elfaky, Abrar K. Thabit, Khalid Eljaaly, Ayat Zawawi, Ahmed S. Abdelkhalek, Ahmad J. Almalki, Tarek S. Ibrahim, Wael A. H. Hegazy   +7 more
doaj   +1 more source

Case series: Continued remission of PTSD symptoms after discontinuation of prazosin

Frontiers in Psychiatry, 2023
Post-traumatic stress disorder is a debilitating chronic illness that affects 6 out of 100 adults after a severe trauma. The alpha-adrenergic antagonist prazosin, which is prescribed off-label for flashbacks and nightmares due to trauma, is often ...
Christie Richardson, Jonathan Yuh, Jing Su, Martin Forsberg   +3 more
doaj   +1 more source

In-vitro Assessment of BCRP-Mediated Efflux of Antiseizure Medications in Human Blood-Brain Barrier Cell Model. [PDF]

J Biochem Mol Toxicol
Efflux transporter ABCG2/BCRP is reported to be overexpressed in drug‐resistant epilepsy that results in decreased bioavailability of antiseizure medications (ASMs) that are its substrates. Interaction of ASMs with BCRP was investigated using ATPase, substrate efflux assay and bidirectional transport assay.
Bora S, Paul PR, Kukal S, Mishra MK, Hasija Y, Kukreti R.   +5 more
europepmc   +2 more sources

Investigation of the Atypical Glass Transition and Recrystallization Behavior of Amorphous Prazosin Salts

Pharmaceutics, 2011
This manuscript studied the effect of counterion on the glass transition and recrystallization behavior of amorphous salts of prazosin. Three amorphous salts of prazosin, namely, prazosin hydrochloride, prazosin mesylate and prazosin tosylate were ...
Arvind K. Bansal, Dharmesh Popat, Lokesh Kumar   +2 more
doaj   +1 more source

Prazosin Can Prevent Glucocorticoid Mediated Capillary Rarefaction. [PDF]

PLoS ONE, 2016
Glucocorticoids (GC) elicit skeletal muscle capillary rarefaction, which can subsequently impair blood distribution and muscle function; however, the mechanisms have not been established.
Erin R Mandel, Emily C Dunford, Anastassia Trifonova, Ghoncheh Abdifarkosh, Trevor Teich, Michael C Riddell, Tara L Haas   +6 more
doaj   +1 more source