Case series: Continued remission of PTSD symptoms after discontinuation of prazosin
Frontiers in Psychiatry, 2023 Post-traumatic stress disorder is a debilitating chronic illness that affects 6 out of 100 adults after a severe trauma. The alpha-adrenergic antagonist prazosin, which is prescribed off-label for flashbacks and nightmares due to trauma, is often ...
Christie Richardson +3 more
doaj +1 more source
Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]
, 2010 The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê +86 more
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α1L-adrenoceptors mediate contraction of human erectile tissue [PDF]
, 2018 α1-adrenoceptor antagonists can impact upon sexual function and have potential in the treatment of erectile dysfunction. Human erectile tissue contains predominantly α1A-adrenoceptors, and here we examined whether contractions of this tissue are mediated
Campbell, Alistair +6 more
core +1 more source
Prazosin Can Prevent Glucocorticoid Mediated Capillary Rarefaction. [PDF]
PLoS ONE, 2016 Glucocorticoids (GC) elicit skeletal muscle capillary rarefaction, which can subsequently impair blood distribution and muscle function; however, the mechanisms have not been established.
Erin R Mandel +6 more
doaj +1 more source
Retrospective Study of Children with Scorpion Envenomation in a Tertiary Care Center of North India [PDF]
Asia Pacific Journal of Medical Toxicology, 2020 Background: Scorpion envenomation is a common public health problem worldwide and children are at greater risk of developing severe cardiac, respiratory and neurological complications.
Rajesh Yadav +4 more
doaj +1 more source
NeuroImage: Clinical, 2020 Background: Higher levels of anxiety, negative affect, and impaired emotion regulation are associated with alcohol use disorder (AUD) and contribute to relapse and worse treatment outcomes.
Claire E. Wilcox +8 more
doaj +1 more source
Single prazosin infusion in prelimbic cortex Fosters extinction of amphetamine-induced conditioned place preference [PDF]
, 2017 Exposure to drug-associated cues to induce extinction is a useful strategy to contrast cue-induced drug seeking. Norepinephrine (NE) transmission in medial prefrontal cortex has a role in the acquisition and extinction of conditioned place preference ...
Alessandro Rava +8 more
core +4 more sources
Prazosin Displays Anticancer Activity against Human Prostate Cancers: Targeting DNA, Cell Cycle
Neoplasia: An International Journal for Oncology Research, 2007 Quinazoline-based α1,-adrenoceptor antagonists, in particular doxazosin, terazosin, are suggested to display antineoplastic activity against prostate cancers. However, there are few studies elucidating the effect of prazosin.
Ssu-Chia Lin +7 more
doaj +1 more source
Diagnostics, 2022 Super-resolution ultrasound imaging, based on the localization and tracking of single intravascular microbubbles, makes it possible to map vessels below 100 µm. Microbubble velocities can be estimated as a surrogate for blood velocity, but their clinical
Sofie Bech Andersen +6 more
doaj +1 more source
α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries [PDF]
, 2013 The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved.
Alexander +53 more
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