Results 21 to 30 of about 12,167 (210)

Prazosin Displays Anticancer Activity against Human Prostate Cancers: Targeting DNA, Cell Cycle

Neoplasia: An International Journal for Oncology Research, 2007
Quinazoline-based α1,-adrenoceptor antagonists, in particular doxazosin, terazosin, are suggested to display antineoplastic activity against prostate cancers. However, there are few studies elucidating the effect of prazosin.
Ssu-Chia Lin, Shih-Chieh Chueht, Che-Jen Hsiao, Tsia-Kun Li, Tzu-Hsuan Chen, Cho-Hwa Liao, Ping-Chiang Lyu, Jih-Hwa Guh   +7 more
doaj   +1 more source

Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress

Life, 2021
Hypertension impairs the function of the kidney and its vasculature. Adrenergic activation is involved in these processes by promoting oxidative stress and mitochondrial dysfunction.
Cristian Adrián Márquez-Ramírez, Berenice Eridani Olmos-Orizaba, Claudia Isabel García-Berumen, Elizabeth Calderón-Cortés, Rocío Montoya-Pérez, Alfredo Saavedra-Molina, Alain Raimundo Rodríguez-Orozco, Christian Cortés-Rojo   +7 more
doaj   +1 more source

Pediatric scorpionism in southwest Turkey: the experience of a training and research hospital

Acta Medica Alanya, 2022
Aim: The aim of this study was to evaluate the clinical and laboratory features and prognosis of scorpion stings in children.Methods: This was a retrospective study of children with scorpion stings, who were admitted to the pediatric emergency department
Ayça Esra Akkaya Kuybulu, Duygu Çalışkan   +1 more
doaj   +1 more source

Retrospective Study of Children with Scorpion Envenomation in a Tertiary Care Center of North India [PDF]

Asia Pacific Journal of Medical Toxicology, 2020
Background:  Scorpion envenomation is a common public health problem worldwide and children are at greater risk of developing severe cardiac, respiratory and neurological complications.
Rajesh Yadav, Muniba Alim, Yogendra Yadav, Dinesh Singh, Alok Kumar   +4 more
doaj   +1 more source

Effectiveness of Sensitisation Programme on Prazosin Therapy for Scorpion Envenomation at Primary and Secondary Healthcare Level [PDF]

Indian Journal of Neonatal Medicine and Research, 2022
Introduction: Scorpion envenomation is a life-threatening paediatric emergency. Prazosin-an alpha-1 blocker is the gold standard therapy for scorpion envenomation. Many children with scorpion envenomation were under-treated at Primary Healthcare (PHC)
B RAMESHBABU, P PUNITHA, E MANOCHITRA, K SASIKALA, J BALAJI   +4 more
doaj   +1 more source

An update on epidemiology and management practices of Scorpion envenomation in India

Journal of Family Medicine and Primary Care, 2022
Introduction: Scorpion envenomation is a life-threatening condition, particularly for children. Therefore, it is essential for primary care health providers to suspect, identify, and manage this condition early to prevent death and minimize morbidity ...
Rakesh Kumar
doaj   +1 more source

Super-Resolution Ultrasound Imaging Can Quantify Alterations in Microbubble Velocities in the Renal Vasculature of Rats

Diagnostics, 2022
Super-resolution ultrasound imaging, based on the localization and tracking of single intravascular microbubbles, makes it possible to map vessels below 100 µm. Microbubble velocities can be estimated as a surrogate for blood velocity, but their clinical
Sofie Bech Andersen, Iman Taghavi, Stinne Byrholdt Søgaard, Carlos Armando Villagómez Hoyos, Michael Bachmann Nielsen, Jørgen Arendt Jensen, Charlotte Mehlin Sørensen   +6 more
doaj   +1 more source

MH-76, a Novel Non-Quinazoline α₁-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats

Pharmaceuticals, 2021
Background: Quinazoline α1-adrenoceptors antagonists have been shown to exert moderately favorable effects on the metabolic profile in hypertensive patients.
Monika Kubacka, Szczepan Mogilski, Monika Zadrożna, Barbara Nowak, Małgorzata Szafarz, Bartosz Pomierny, Henryk Marona, Anna Waszkielewicz, Wojciech Jawień, Jacek Sapa, Marek Bednarski, Joanna Knutelska, Magdalena Kotańska   +12 more
doaj   +1 more source

Management of scorpion envenoming: a systematic review and meta-analysis of controlled clinical trials

Systematic Reviews, 2017
Background Scorpion stings cause an estimated 3000 deaths per annum worldwide. We conducted a systematic review of all controlled clinical trials related to scorpion sting management.
Chaturaka Rodrigo, Ariaranee Gnanathasan
doaj   +1 more source

Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats

Pharmaceutics, 2020
The potential inhibitory effect of quercetin, a major plant flavonol, on breast cancer resistance protein (BCRP) activity was investigated in this study.
Yoo-Kyung Song, Jin-Ha Yoon, Jong Kyu Woo, Ju-Hee Kang, Kyeong-Ryoon Lee, Seung Hyun Oh, Suk-Jae Chung, Han-Joo Maeng   +7 more
doaj   +1 more source