Results 31 to 40 of about 12,167 (210)

Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3.

PLoS ONE, 2018
We observed in PRESTO-Tango β-arrestin recruitment assays that the α1-adrenergic receptor (AR) antagonist prazosin activates chemokine (C-X-C motif) receptor (CXCR)4. This prompted us to further examine this unexpected pharmacological behavior.
Xianlong Gao, Hazem Abdelkarim, Lauren J Albee, Brian F Volkman, Vadim Gaponenko, Matthias Majetschak   +5 more
doaj   +1 more source

The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway

EMBO Molecular Medicine, 2016
A variety of drugs targeting monoamine receptors are routinely used in human pharmacology. We assessed the effect of these drugs on the viability of tumor‐initiating cells isolated from patients with glioblastoma.
Suzana Assad Kahn, Silvia Lima Costa, Sharareh Gholamin, Ryan T Nitta, Luiz Gustavo Dubois, Marie Fève, Maria Zeniou, Paulo Lucas Cerqueira Coelho, Elias El‐Habr, Josette Cadusseau, Pascale Varlet, Siddhartha S Mitra, Bertrand Devaux, Marie‐Claude Kilhoffer, Samuel H Cheshier, Vivaldo Moura‐Neto, Jacques Haiech, Marie‐Pierre Junier, Hervé Chneiweiss   +18 more
doaj   +1 more source

Prazosin-Conjugated Matrices Based on Biodegradable Polymers and α-Amino Acids—Synthesis, Characterization, and in Vitro Release Study

Molecules, 2015
Novel and promising macromolecular conjugates of the α1-adrenergic blocker prazosin were directly synthesized by covalent incorporation of the drug to matrices composed of biodegradable polymers and α-amino acids for the development of a polymeric ...
Ewa Oledzka, Anna Sawicka, Marcin Sobczak, Grzegorz Nalecz-Jawecki, Agata Skrzypczak, Waclaw Kolodziejski   +5 more
doaj   +1 more source

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document

European Journal of Heart Failure, EarlyView.
Main categories of harmful drugs in heart failure. CCB, calcium channel blocker; DPP4i, dipeptidyl peptidase‐4 inhibitor; HER2‐TT, human epidermal growth factor receptor 2‐targeted therapy; NSAID, non‐steroidal anti‐inflammatory drug; TKI, tyrosine kinase inhibitor; TZD, thiazolidinedione; VEGF Inh, vascular endothelial growth factor inhibitor.
Amr Abdin, Johann Bauersachs, Magdy Abdelhamid, Suleman Aktaa, Hussam Al Ghorani, Antonio Bayes‐Genis, Jan Biegus, Michael Böhm, Javed Butler, Nicolas Girerd, Marco Metra, Wilfried Mullens, Hadi Skouri, Muthiah Vaduganathan, Seif El Hadidi, Giuseppe M.C. Rosano, Gianluigi Savarese   +16 more
wiley   +1 more source

Rapid eye movement sleep deprivation induced gene regulation for modulation of noradrenaline level in brain regions of rats: Implications with chronic sleep‐loss associated pathophysiological conditions

Neuroprotection, EarlyView.
Proposed mechanism for transcriptional regulation of tyrosine hydroxylase (TH), dopamine β hydroxylase (DBH) and monoamine oxidase‐A (MAO‐A) genes during rapid eye movement sleep (REMS) or its loss. Increased histone acetylation and decreased histone methylation of TH and DBH gene favor chromatin opening, increase in gene expressions, increased enzyme ...
Rachna Mehta, Raghavendra Murali, Birendra Nath Mallick   +2 more
wiley   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

A non-randomized pilot trial of the use of prazosin in the prevention of transition from acute stress disorder to post-traumatic stress disorder

European Journal of Psychotraumatology, 2023
Background: Following a traumatic event, 40–80% of the patients with acute stress disorder (ASD) will develop post-traumatic stress disorder (PTSD), 67% at 6 months.
Charline Magnin, Emmanuel Poulet, Laurent Fanton, Philippe Vignaud, Jerome Brunelin   +4 more
doaj   +1 more source

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

Electronic medical records-based retrospective, longitudinal, observational study to understand the patient management of benign prostatic hyperplasia with alpha-blockers monotherapy in Indian population

Urology Annals, 2023
Objective: The present retrospective study evaluates the effectiveness and tolerability of alpha-blockers as monotherapy in patients with benign prostatic hyperplasia associated with lower urinary tract symptoms (LUTS).
Rahul Gupta, Sameer Trivedi, Surya Prakash Vaddi, Mrinal Borgohain, Rajan Mittal, Sucheta Pandit, Amey Mane   +6 more
doaj   +1 more source

Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial ...
Brian Edwin Cairns
wiley   +1 more source