Results 41 to 50 of about 22,455 (256)

MH-76, a Novel Non-Quinazoline α₁-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats

Pharmaceuticals, 2021
Background: Quinazoline α1-adrenoceptors antagonists have been shown to exert moderately favorable effects on the metabolic profile in hypertensive patients.
Monika Kubacka, Szczepan Mogilski, Monika Zadrożna, Barbara Nowak, Małgorzata Szafarz, Bartosz Pomierny, Henryk Marona, Anna Waszkielewicz, Wojciech Jawień, Jacek Sapa, Marek Bednarski, Joanna Knutelska, Magdalena Kotańska   +12 more
doaj   +1 more source

Management of scorpion envenoming: a systematic review and meta-analysis of controlled clinical trials

Systematic Reviews, 2017
Background Scorpion stings cause an estimated 3000 deaths per annum worldwide. We conducted a systematic review of all controlled clinical trials related to scorpion sting management.
Chaturaka Rodrigo, Ariaranee Gnanathasan
doaj   +1 more source

Always Consider a Repeat Kidney Biopsy: Acute Interstitial Nephritis Soon After Membranous Nephropathy [PDF]

Case Rep Nephrol
Introduction The heterogeneity of membranous nephropathy is well described in the literature, and its clinical course and response to treatment vary. Similarly, acute interstitial nephritis (AIN) can present in unexpected and unusual ways and should always be considered within the differential diagnosis of worsening renal function.
Hopkins J, Nolan J, Ladhani M, Lee C.
europepmc   +2 more sources

Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3.

PLoS ONE, 2018
We observed in PRESTO-Tango β-arrestin recruitment assays that the α1-adrenergic receptor (AR) antagonist prazosin activates chemokine (C-X-C motif) receptor (CXCR)4. This prompted us to further examine this unexpected pharmacological behavior.
Xianlong Gao, Hazem Abdelkarim, Lauren J Albee, Brian F Volkman, Vadim Gaponenko, Matthias Majetschak   +5 more
doaj   +1 more source

Hepatic fibrogenesis requires sympathetic neurotransmitters [PDF]

, 2004
Background and aims: Hepatic stellate cells (HSC) are activated by liver injury to become proliferative fibrogenic myofibroblasts. This process may be regulated by the sympathetic nervous system (SNS) but the mechanisms involved are unclear.
Diehl, AM, Huang, J, Li, Z, Lin, H, Moran, TH, Oben, JA, Roskams, T, Sinelli, N, Smedh, U, Thomas, SA, Torbenson, M, Yang, S   +11 more
core   +2 more sources

The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway

EMBO Molecular Medicine, 2016
A variety of drugs targeting monoamine receptors are routinely used in human pharmacology. We assessed the effect of these drugs on the viability of tumor‐initiating cells isolated from patients with glioblastoma.
Suzana Assad Kahn, Silvia Lima Costa, Sharareh Gholamin, Ryan T Nitta, Luiz Gustavo Dubois, Marie Fève, Maria Zeniou, Paulo Lucas Cerqueira Coelho, Elias El‐Habr, Josette Cadusseau, Pascale Varlet, Siddhartha S Mitra, Bertrand Devaux, Marie‐Claude Kilhoffer, Samuel H Cheshier, Vivaldo Moura‐Neto, Jacques Haiech, Marie‐Pierre Junier, Hervé Chneiweiss   +18 more
doaj   +1 more source

Utility of Fear Severity and Individual Resilience Scoring as a Surge Capacity, Triage Management Tool during Large-Scale, Bio-event Disasters [PDF]

, 2006
Threats of bioterrorism and emerging infectious disease pandemics may result in fear related consequences. Fear based signs and symptoms, if left undetected and untreated, may be extremely debilitating and lead to chronic problems with risk of permanent ...
Bracha, H. Stefan, Burkle Jr., Frederick M.   +1 more
core   +1 more source

Prazosin-Conjugated Matrices Based on Biodegradable Polymers and α-Amino Acids—Synthesis, Characterization, and in Vitro Release Study

Molecules, 2015
Novel and promising macromolecular conjugates of the α1-adrenergic blocker prazosin were directly synthesized by covalent incorporation of the drug to matrices composed of biodegradable polymers and α-amino acids for the development of a polymeric ...
Ewa Oledzka, Anna Sawicka, Marcin Sobczak, Grzegorz Nalecz-Jawecki, Agata Skrzypczak, Waclaw Kolodziejski   +5 more
doaj   +1 more source

Autoimmunity to Collagen XVII (BP180‐Ag2) in Pemphigoid Associated With Parkinson’s Disease [PDF]

Case Reports in Dermatological Medicine
The association between Parkinson’s disease and autoimmune disease is rare; in our population, there is 1 case per 10,000 inhabitants. Bullous pemphigoid has a much lower incidence, and consequently, the association of Parkinson’s disease and bullous pemphigoid is rarer.
Cid-Puente R, Ornelas-Ramírez I, González-Herrera L, Bollain-y-Goytia J, Avalos-Diaz E, Herrera-Esparza R.   +5 more
europepmc   +2 more sources

REM sleep in acutely traumatized individuals and interventions for the secondary prevention of post-traumatic stress disorder [PDF]

, 2020
Increasing evidence supports a close link between REM sleep and the consolidation of emotionally toned memories such as traumatic experiences. In order to investigate the role of sleep for the development of symptoms related to traumatic experiences ...
Bublitz, Jan Christoph, Danker-Hopfe, Heidi, Dresler, Martin, Kühn, Simone, Repantis, Dimitris, Tsamitros, Nikolaos, Wermuth, Katharina   +6 more
core   +1 more source