Results 41 to 50 of about 12,167 (210)

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

Efficacy of scorpion antivenom plus prazosin compared with prazosin alone for scorpion sting in children: A cross sectional study [PDF]

Al Ameen Journal of Medical Sciences
Background: Scorpion sting can pose as a life threatening acute medical emergency, which, if not attended to on an emergency basis can result in mortality. Scorpion venoms are a composed of a complex mixture of proteins.
R. Nagarjun, Pooja G. Manoli, A. Ashoka
doaj  

Optimizing Aggregated N-Of-1 Trial Designs for Predictive Biomarker Validation: Statistical Methods and Theoretical Findings

Frontiers in Digital Health, 2020
Background and Significance: Parallel-group randomized controlled trials (PG-RCTs) are the gold standard for detecting differences in mean improvement across treatment conditions.
Rebecca C. Hendrickson, Rebecca C. Hendrickson, Ronald G. Thomas, Nicholas J. Schork, Nicholas J. Schork, Murray A. Raskind, Murray A. Raskind   +6 more
doaj   +1 more source

Presentation, diagnosis and treatment of a prostatic abscess in an adult, male, neutered cat

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 6‐year‐old, male, neutered Maine Coon cat presented with a 1‐week history of hyporexia, stranguria, pollakiuria and dysuria. Investigations, including abdominal ultrasound, positive contrast retrograde urethrocystogram and cytology of the prostate, were most consistent with a prostatic abscess.
Lydia Bloomfield, Natasha May, Andrea Holmes, Anna Frykfors von Hekkel   +3 more
wiley   +1 more source

The Role of Central Catecholaminergic Systems in Regulation of Food Intake of Chicks

The Journal of Poultry Science, 2001
To clarify catecholaminergic systems on the regulation of food intake in the neonatal chick, we examined the effects of intracerebroventricular (ICV) injection of prazosin (α1-adrenoceptor antagonist), yohimbine (α2-adrenoceptor antagonist ...
Takashi Bungo, Ryuichi Ando, Sin-Ichi Kawakami, Atsushi Ohgushi, Mitsuhiro Furuse   +4 more
doaj   +1 more source

Preoperative Amlodipine Is More Efficacious Than Prazosin in Preventing Intraoperative Haemodynamic Instability in Pheochromocytoma/Paraganglioma Patients: Interim Analysis of a Pilot Randomized Controlled Study [PDF]

, 2021
Saba Samad Memon, Sanjeet Kumar Jaiswal, Robin Garg, Rohit Barnabas, Manjunath Goroshi, Anurag Lila, Vijaya Sarathi, Abhay Dalvi, Mahadeo Garale, Indrani Hemantkumar, Rajendra Patel, Shrikanta Oak, Virendra Patil, Nalini S. Shah, Tushar Bandgar   +14 more
openalex   +1 more source

Integrative Evidence From Metabolome‐Wide Mendelian Randomization and Animal Models Implicates Tyrosine in Cardiac Hypercontractility and Arrhythmia Risk

Food Frontiers, Volume 7, Issue 1, January 2026.
Plasma metabolome‐wide Mendelian randomization analysis established a causal link between tyrosine and arrhythmia. GWAS meta‐analysis identified tyrosine‐associated loci linked to cardiovascular risk factors. Animal studies confirmed that oral tyrosine intake modulates heart rhythm via adrenergic signaling activation.
Zhikang Cao, Huiying Liu, Peng Chen, Liyue Chen, Zhixin Chen, Jiaqiang Lin, Zixuan Fu, Zhipeng Li   +7 more
wiley   +1 more source

Prazosin use in a patient with rare Neurobeachin gene deletion shows improvement in paranoid behavior: a case report

Journal of Medical Case Reports, 2021
Background Disruption of the Neurobeachin gene is a rare genetic mutation that has been implicated in the development of autism and enhanced long-term potentiation of the hippocampal CA1 region, causing a heightened conditioned fear response and impaired
Christina Y. Cantwell, Jamie Fortman, Alexis Seegan   +2 more
doaj   +1 more source

Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis

British Journal of Pharmacology, Volume 183, Issue 2, Page 280-295, January 2026.
Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan, Alanna G. Spiteri, Pranav Runwal, Jiaqi Sun, Dana S. Hutchinson, Yoshiteru Kagawa, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo   +10 more
wiley   +1 more source

Use of Prazosin for Pediatric Post-Traumatic Stress Disorder With Nightmares and/or Sleep Disorder: Case Series of 18 Patients Prospectively Assessed

Frontiers in Psychiatry, 2020
ObjectivesFew studies have investigated pharmacologic treatment for pediatric post-traumatic stress disorder (PTSD). Prazosin, an alpha-1 adrenergic receptor antagonist, has been studied and demonstrated to be efficacious in an adult population for PTSD ...
Vladimir Ferrafiat, Vladimir Ferrafiat, Maryam Soleimani, Maryam Soleimani, Boris Chaumette, Audrey Martinez, Jean-Marc Guilé, Jean-Marc Guilé, Jean-Marc Guilé, Brooks Keeshin, Priscille Gerardin, Priscille Gerardin   +11 more
doaj   +1 more source