Results 71 to 80 of about 22,455 (256)

Procedural separation of appetitive and consummatory behaviors in operant ethanol self‐administration: A review and open‐source analytical framework

Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.
This review highlights the biphasic sipper model pioneered by Dr. Hank Samson's laboratory, which separates appetitive and consummatory behaviors in rodent ethanol self‐administration. Over two decades of research using this paradigm reveals that alcohol‐directed behaviors are dynamic, shaped by internal states, cues, and experience.
Olivia A. Colarusso, Jeffrey L. Weiner
wiley   +1 more source

Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed [PDF]

, 2014
The relative importance of ATP as a functional sympathetic neurotransmitter in blood vessels has been shown to be increased when the level of preexisting vascular tone or pressure is increased, in studies carried out in rat mesenteric arteries.
A Saul, A Shatarat, Amjad Shatarat, B Bhattacharya, C Vial, CJ Lewis, DC Eikenburg, DD McGregor, DP Gitterman, EW Inscho, G Burnstock, G Burnstock, G Burnstock, G Burnstock, GJ Crane, GM Rubanyi, JA Roberts, JQ Kong, L Shaw, M Yeoh, MJ Mulvany, MM Swindle, MV Donoso, N Montano, NM Rummery, P Pakdeechote, RA North, RC Van, RE Roberts, SC Malpas, TJ Williams, V Ralevic, Vera Ralevic, William R. Dunn, Y Tabuchi   +34 more
core   +2 more sources

Effect of Antihypertensive Treatment on Hypotension, Mortality and Length of Stay in Orthopedic Trauma and First Detected High Blood Pressure Adults in a Large Urban Hospital: A Retrospective Cohort Study

The Journal of Clinical Hypertension, Volume 28, Issue 2, February 2026.
ABSTRACT Trauma is a frequent cause of hospital admission in adults, and while arterial hypertension is common in the general population, reactive hypertension associated with trauma remains poorly studied from a therapeutic perspective. This retrospective cohort study aimed to estimate the impact of antihypertensive treatment on hypotension occurrence,
Carlos José Atencia, Fabian Jaimes
wiley   +1 more source

The Role of Central Catecholaminergic Systems in Regulation of Food Intake of Chicks

The Journal of Poultry Science, 2001
To clarify catecholaminergic systems on the regulation of food intake in the neonatal chick, we examined the effects of intracerebroventricular (ICV) injection of prazosin (α1-adrenoceptor antagonist), yohimbine (α2-adrenoceptor antagonist ...
Takashi Bungo, Ryuichi Ando, Sin-Ichi Kawakami, Atsushi Ohgushi, Mitsuhiro Furuse   +4 more
doaj   +1 more source

Integrative Evidence From Metabolome‐Wide Mendelian Randomization and Animal Models Implicates Tyrosine in Cardiac Hypercontractility and Arrhythmia Risk

Food Frontiers, Volume 7, Issue 1, January 2026.
Plasma metabolome‐wide Mendelian randomization analysis established a causal link between tyrosine and arrhythmia. GWAS meta‐analysis identified tyrosine‐associated loci linked to cardiovascular risk factors. Animal studies confirmed that oral tyrosine intake modulates heart rhythm via adrenergic signaling activation.
Zhikang Cao, Huiying Liu, Peng Chen, Liyue Chen, Zhixin Chen, Jiaqiang Lin, Zixuan Fu, Zhipeng Li   +7 more
wiley   +1 more source

Effects of bcrp and p-gp modulators on the penetration of aflatoxin b1 into the mouse brain [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017
This study was conducted to determine whether the plasma and brain concentrations of AFB1 are affected by the modulation of P-gp and BCRP using zosuquidar (ZQR) and prazosin (PRZ), respectively. In this study, a total of 40 healthy adult male BALB/c mice
TRAS B, CETIN G, UNEY K, DIK B, CORUM O, ATALAY S   +5 more
doaj   +1 more source

Prazosin + Naltrexone Decreases Alcohol Drinking More Effectively Than Does Either Drug Alone in P Rats with a Protracted History of Extensive Voluntary Alcohol Drinking, Dependence, and Multiple Withdrawals [PDF]

, 2015
Background Prazosin (PRZ, an α1-adrenergic receptor antagonist) and naltrexone (NTX, a non-specific opioid receptor antagonist) each decrease alcohol drinking when administered to rats selectively-bred for high voluntary alcohol drinking (alcohol ...
Froehlich, Janice C., Kincaid, Carrie L., Rasmussen, Dennis D.   +2 more
core   +1 more source

Critical evaluation of real‐world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Reina Tonegawa‐Kuji, Ehud Karavani, Michael Danziger, Pengyue Zhang, Yuan Hou, Yadi Zhou, Marina Bykova, Andrew A. Pieper, Michal Rosen‐Zvi, Jeffrey Cummings, Feixiong Cheng   +10 more
wiley   +1 more source

Impact of sympathetic nervous system activity on post-exercise flow-mediated dilatation in humans [PDF]

, 2015
Transient reduction in vascular function following systemic large muscle group exercise has previously been reported in humans. The mechanisms responsible are currently unknown. We hypothesised that sympathetic nervous system activation, induced by cycle
Atkinson, Birk, Birk, Black, Carter, Ceri L. Atkinson, Chappell, Chowdhary, Cleroux, Conway, Daniel J. Green, Dawson, Dawson, Dick H.J. Thijssen, Donato, Dyson, Ellis, Ghiadoni, Gocke, Goel, Green, Green, Green, Halliwill, Hastings, Hijmering, Howard H. Carter, Johnson, Johnson, Johnson, Jones, Jones, Kolo, Kulics, Laughlin, Lewis, Lewis, Lewis, Lind, Maiorana, Nia C.S. Lewis, Padilla, Padilla, Padilla, Philip N. Ainslie, Plantinga, Richardson, Rosenmeier, Schreuder, Silvestro, Simmons, Spieker, Sugawara, Takase, Thijssen, Thijssen, Thijssen, Thijssen, Tinken, Tinken, Tinken, Vo, Watts, Woodman, Wray, Wray, Zanzinger, Ziegler   +67 more
core   +1 more source

Clozapine and olanzapine, but not haloperidol, suppress serotonin efflux in the medial prefrontal cortex elicited by phencyclidine and ketamine [PDF]

, 2006
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP) and ketamine can evoke psychotic symptoms in normal individuals and schizophrenic patients.
D. Hanisch, G. Liu, H.P. Kriegel, L. Pitsoulis, S. Günnemann, S. Günnemann, Y. Zhou   +6 more
core   +1 more source