Results 81 to 90 of about 22,455 (256)

Increased ATP production and P‐glycoprotein activity underlie the marked changes in blood–brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis

British Journal of Pharmacology, Volume 183, Issue 2, Page 280-295, January 2026.
Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan, Alanna G. Spiteri, Pranav Runwal, Jiaqi Sun, Dana S. Hutchinson, Yoshiteru Kagawa, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo   +10 more
wiley   +1 more source

THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES

Journal of Research in Medical Sciences, 2003
Introduction: Several studies have shown noradrenergic system hyperactivity in posttraumatic stress disorder. Four Vietnam combat veterans with chronic PTSD, prescribed prazosin ?1 adrenergic receptor antagonist reported reduction or completely ...
G ASSADOUAHI, GH AHMADZADEH, J MAHMOUDI GHARAEI, N BASHARDOOST, T FAGHIHI   +4 more
doaj  

Retrospective study of outcome in patients with scorpion sting using prazosin with/without dobutamine

Asian Journal of Medical Sciences, 2015
Introduction: Scorpion sting is a major public health problem in India with severe life threatening complications. Toxin can cause autonomic overstimulation leading to hypertension, arrhythmias and pulmonary edema with left ventricular dysfunction ...
L Venugopal
doaj   +1 more source

Comparison of 7 α1-adrenoceptor Antagonists in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia:A Short-term Crossover Study [PDF]

, 2013
A crossover study was conducted to identify the best α1-adrenoceptor (α1AR) antagonist for individual patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). One hundred thirteen patients (mean age 70.8 years)
Araki, Motoo, Araki, Tohru, Monden, Koichi   +2 more
core   +1 more source

Diagnostic Challenges of Adrenal Venous Sampling for Primary Hyperaldosteronism in a Patient With Subclinical Cushing's Syndrome: A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Hypertension is a significant comorbidity in the New World, and its prevalence is rising. Around 5%–10% of cases with hypertension have secondary hypertension. Adrenal gland disease is among the common causes of secondary hypertension. We present a 57‐year‐old male with uncontrolled hypertension and a history of intracranial hemorrhage.
Mahsa Malekian, Vahide Sadra, Amir Bahrami, Javad Jalili, Hamidreza Ashayeri   +4 more
wiley   +1 more source

Regulation mechanism of AT1R/miR-26a pathway in hypertensive vascular remodeling

Di-san junyi daxue xuebao, 2020
Objective To elucidate the important role and molecular mechanism of AT1R/miR-26a pathway in hypertensive vascular remodeling. Methods ① Eight-week-old male spontaneously hypertensive rats (SHRs) were randomly divided into losartan group [gavage with ...
ZHANG Wenqian, WANG Qiaozhu, SHI Peifei, FENG Yanjing, GAO Dengfeng, LIU Xin   +5 more
doaj   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1463-1476, December 2025.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Propranolol and Prazosin Have a Positive Effect on the Sexual Performance of Female Three-Spot Gourami [PDF]

Journal of Kerman University of Medical Sciences
Background: Sexual function is one of the most important aspects of life and is likely to be affected by the side effects of antihypertensive drugs. This study aimed to evaluate the effect of propranolol and prazosin on the sexual performance of female ...
Marzieh Monemi, Tahereh Naji, Afshin Kheradmand   +2 more
doaj   +1 more source

Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish [PDF]

, 2015
Pharmacological studies in mammals suggest that norepinephrine (NE) plays an important role in promoting arousal. However, the role of endogenous NE is unclear, with contradicting reports concerning the sleep phenotypes of mice lacking NE due to mutation
Oikonomou, Grigorios, Prober, David A., Singh, Chanpreet   +2 more
core   +1 more source

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document

European Journal of Heart Failure, Volume 27, Issue 12, Page 2671-2690, December 2025.
Main categories of harmful drugs in heart failure. CCB, calcium channel blocker; DPP4i, dipeptidyl peptidase‐4 inhibitor; HER2‐TT, human epidermal growth factor receptor 2‐targeted therapy; NSAID, non‐steroidal anti‐inflammatory drug; TKI, tyrosine kinase inhibitor; TZD, thiazolidinedione; VEGF Inh, vascular endothelial growth factor inhibitor.
Amr Abdin, Johann Bauersachs, Magdy Abdelhamid, Suleman Aktaa, Hussam Al Ghorani, Antonio Bayes‐Genis, Jan Biegus, Michael Böhm, Javed Butler, Nicolas Girerd, Marco Metra, Wilfried Mullens, Hadi Skouri, Muthiah Vaduganathan, Seif El Hadidi, Giuseppe M.C. Rosano, Gianluigi Savarese   +16 more
wiley   +1 more source