Results 31 to 40 of about 127,576 (188)

Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits. [PDF]

PLoS ONE, 2012
BACKGROUND: NIR was identified as an inhibitor of histone acetyltransferase and it represses transcriptional activation of p53. NIR is predominantly localized in the nucleolus and known as Noc2p, which is involved in the maturation of the 60S ribosomal ...
Jianguo Wu, Ying Zhang, Yingshuang Wang, Ruirui Kong, Lelin Hu, Roland Schuele, Xiaojuan Du, Yang Ke   +7 more
doaj   +1 more source

A high-throughput assay for directly monitoring nucleolar rRNA biogenesis

Open Biology, 2022
Studies of the regulation of nucleolar function are critical for ascertaining clearer insights into the basic biological underpinnings of ribosome biogenesis (RB), and for future development of therapeutics to treat cancer and ribosomopathies.
Carson J. Bryant, Mason A. McCool, Laura Abriola, Yulia V. Surovtseva, Susan J. Baserga   +4 more
doaj   +1 more source

A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization. [PDF]

Proc Natl Acad Sci U S A, 2014
Significance RNA regulation occurs at many levels including processing to mature forms, subcellular localization, and translation. RNA-binding proteins are crucial to direct and regulate these processes. Pumilio/feminization of XX and XO animals (fem)-3 mRNA-binding factor (PUF) proteins are RNA-binding proteins formed from eight α-helical ...
Qiu C, McCann KL, Wine RN, Baserga SJ, Hall TM.   +4 more
europepmc   +4 more sources

Yeast Polypeptide Exit Tunnel Ribosomal Proteins L17, L35, and L37 are Necessary to Recruit Late-assembling Factors Required for 27SB Pre-rRNA Processing [PDF]

, 2012
Ribosome synthesis involves the coordinated folding and processing of pre-rRNAs with assembly of ribosomal proteins. In eukaryotes, these events are facilitated by trans-acting factors that propel ribosome maturation from the nucleolus to the cytoplasm ...
Babiano González, Reyes, Cruz Díaz, Jesús de la, Gamalinda, Michael, Jakovljevic, Jelena, Talkish, Jason, Woolford, John L.   +5 more
core   +1 more source

Pre-rRNA processing and its response to temperature stress in maize [PDF]

Journal of Experimental Botany, 2019
Abstract Ribosome biogenesis is a fundamental process in all eukaryotic cells and is coupled with the processing and maturation of pre-rRNAs. Maize is the primary staple crop across the world. However, little is known about the exact pre-rRNA processing sites and pathways in maize.
Guoqin, Liu, Pengshuai, Yan, Qingguo, Du, Yafei, Wang, Yu, Guo, Zhiyuan, Fu, Hongqiu, Wang, Jihua, Tang   +7 more
openaire   +2 more sources

Yeast pre-rRNA processing and modification occur cotranscriptionally. [PDF]

Mol Cell, 2010
To better understand yeast ribosome synthesis, we developed techniques for the rapid harvesting and analysis of metabolically labeled cultures. Modeling of the resulting kinetic data allowed predicted lifetimes and processing patterns to be compared with the experimental data.
Kos M, Tollervey D.
europepmc   +3 more sources

Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5′-3′ exoribonuclease) in the nucleoplasm [PDF]

, 2015
Collaborator of alternative reading frame protein (CARF) associates directly with ARF, p53, and/or human double minute 2 protein (HDM2), a ubiquitin-protein ligase, without cofactors and regulates cell proliferation by forming a negative feedback loop ...
Bertwistle, Harunori Yoshikawa, Hasan, Hideaki Ishikawa, Keiichi Izumikawa, Nobuhiro Takahashi, Richard J. Simpson, Sauer, Shigeko Sato, Sugimoto, Yanagida, Yi, Zhang, Zhang   +13 more
core   +2 more sources

Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase [PDF]

, 2008
In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA—U3, U14 and snR30—whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the
Bohnsack, Markus, Kos, Martin, Tollervey, David   +2 more
core   +2 more sources

Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]

, 2012
Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Entian, Karl-Dieter, Kötter, Peter, Lamberth, Stefanie, Peifer, Christian, Sharma, Sunny, Watzinger, Peter   +5 more
core   +1 more source

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Arora, Baird, Beugnet, Boultwood, Brandenburger, Brenneisen, Browne, Chresta, Christopher G. Proud, Dong, Drygin, Dunlop, Feldman, Fonseca, Fonseca, Fumagalli, Gingras, Grimm, Hannan, Hara, Holzel, Horn, Horos, Huang, Iadevaia, Iadevaia, Jastrzebski, Jefferies, Julien Averous, Killian, Kimball, Kispal, Lam, Le-Bacquer, Lempiainen, Lempiainen, Loreni, Mayer, Mayer, Meyuhas, Miluzio, Montanaro, Oshiro, Patursky-Polischuk, Pearce, Pearson, Peter M. Taylor, Pianese, Popowski, Proud, Redpath, Rodnina, Rohrmoser, Rui Liu, Sancak, Sancak, Sanchez, Sarbassov, Smith, Strezoska, Strezoska, Thoreen, Valentina Iadevaia, Wang, Wang, Willett, Xiao, Yip, Ze Zhang   +68 more
core   +6 more sources