Results 11 to 20 of about 127,576 (188)

Ribonucleoproteins in archaeal pre-rRNA processing and modification. [PDF]

Archaea, 2013
Given that ribosomes are one of the most important cellular macromolecular machines, it is not surprising that there is intensive research in ribosome biogenesis. Ribosome biogenesis is a complex process. The maturation of ribosomal RNAs (rRNAs) requires not only the precise cleaving and folding of the pre-rRNA but also extensive nucleotide ...
Yip WS, Vincent NG, Baserga SJ.
europepmc   +5 more sources

Loss of both wobbleU34 modifications in mcm5s2U tRNAs impairs rRNA biosynthesis, growth, and development in Arabidopsis thaliana [PDF]

Frontiers in Plant Science
In eukaryotic cells, the first anticodon uridine base of cytosolic tRNALys(UUU), tRNAGlu(UUC), and tRNAGln(UUG) (wobbleU34) is post transcriptionally modified through adding a methoxycarbonylmethyl group and substituting a sulfur at the fifth and second ...
Yumi Nakai, Yukio Kurihara, Yuko Makita, Yuko Makita, Gorou Horiguchi, Gorou Horiguchi, Kosei Iwabuchi, Akiko Harada, Masato Nakai, Takato Yano   +9 more
doaj   +2 more sources

RECQ5 mediates pre-rRNA processing in nucleolus. [PDF]

Nucleic Acids Res
Abstract RECQ5 is a member of the RECQ helicase family that maintains genomic stability. However, the molecular mechanism of RECQ5 in this biological process remains elusive. Here, we show that RECQ5 localizes in the dense fibrillar component of nucleolus and associates with several pre-rRNA processing factors. It recognizes pre-rRNA and
Ma Y, Yu X.
europepmc   +3 more sources

Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
Pan Zhu, Yuqiu Wang, Nanxun Qin
exaly   +2 more sources

REIIBP methylates nucleolar proteins and regulates pre-rRNA processing. [PDF]

J Biol Chem
The NSD2 (nuclear receptor binding SET [Suppressor of variegation 3-9, Enhancer of zeste, and Trithorax] domain protein 2) gene encodes a short isoform, REIIBP (interleukin-5 response element II binding protein), via alternative transcription initiation. It is particularly overexpressed in t(4;14)+ multiple myeloma. However, the biological functions of
Yang Q, Yu X.
europepmc   +4 more sources

The nucleolar protein SAHY1 is involved in pre-rRNA processing and normal plant growth. [PDF]

Plant Physiol, 2021
AbstractAlthough the nucleolus is involved in ribosome biogenesis, the functions of numerous nucleolus-localized proteins remain unclear. In this study, we genetically isolated Arabidopsis thaliana salt hypersensitive mutant 1 (sahy1), which exhibits slow growth, short roots, pointed leaves, and sterility.
Hsu PJ, Tan MC, Shen HL, Chen YH, Wang YY, Hwang SG, Chiang MH, Le QV, Kuo WS, Chou YC, Lin SY, Jauh GY, Cheng WH.   +12 more
europepmc   +4 more sources

Endonucleolytic processing plays a critical role in the maturation of ribosomal RNA in Methanococcus maripaludis

RNA Biology, 2023
Ribosomal RNA (rRNA) processing and maturation are fundamentally important for ribosome biogenesis, but the mechanisms in archaea, the third form of life, remains largely elusive.
Lei Qi, Huan Liu, Jian Gao, Kai Deng, Xiaoyan Wang, Xiuzhu Dong, Jie Li   +6 more
doaj   +1 more source

The nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis

BMC Plant Biology, 2023
Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek, Anna Golisz-Mocydlarz, Michal Krzyszton, Justyna Piotrowska, Malgorzata Lichocka, Joanna Kufel   +5 more
doaj   +1 more source

Rrp5 binding at multiple sites coordinates pre-rRNA processing and assembly. [PDF]

Mol Cell, 2013
In vivo UV crosslinking identified numerous preribosomal RNA (pre-rRNA) binding sites for the large, highly conserved ribosome synthesis factor Rrp5. Intramolecular complementation has shown that the C-terminal domain (CTD) of Rrp5 is required for pre-rRNA cleavage at sites A0-A2 on the pathway of 18S rRNA synthesis, whereas the N-terminal domain (NTD)
Lebaron S, Segerstolpe A, French SL, Dudnakova T, de Lima Alves F, Granneman S, Rappsilber J, Beyer AL, Wieslander L, Tollervey D.   +9 more
europepmc   +5 more sources

Critical Role of Nucleostemin in Pre-rRNA Processing [PDF]

Journal of Biological Chemistry, 2009
Nucleostemin is a nucleolar protein widely expressed in proliferating cells. Nucleostemin is involved in the regulation of cell proliferation, and both depletion and overexpression of nucleostemin induce cell cycle arrest through the p53 signaling pathway. Although the presence of p53-independent functions of nucleostemin has been previously suggested,
Liudmila, Romanova, Anthony, Grand, Liying, Zhang, Samuel, Rayner, Nobuko, Katoku-Kikyo, Steven, Kellner, Nobuaki, Kikyo   +6 more
openaire   +2 more sources