Human nucleolar protein SURF6/RRP14 participates in early steps of pre-rRNA processing. [PDF]
PLoS ONE, 2023 The biogenesis of ribosomes requires tightly controlled transcription and processing of pre-rRNA which comprises ribosomal RNAs forming the core of large and small ribosomal subunits.
Anastasiia Moraleva +9 more
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HIV-1 infection causes a down-regulation of genes involved in ribosome biogenesis. [PDF]
PLoS ONE, 2014 HIV-1 preferentially infects CD4+ T cells, causing fundamental changes that eventually lead to the release of new viral particles and cell death. To investigate in detail alterations in the transcriptome of the CD4+ T cells upon viral infection, we ...
Claudia L Kleinman +6 more
doaj +22 more sources
Regulation of Pre-rRNA Processing in Plant: Mechanisms, Plasticity, and Developmental Implications [PDF]
PlantsRibosome biogenesis is a fundamental process underlying plant growth, development, and environmental adaptation, and processing of precursor rRNA (pre-rRNA) represents one of its most critical regulatory steps.
Nier Chen +3 more
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BMAL1 Associates with NOP58 in the Nucleolus and Contributes to Pre-rRNA Processing [PDF]
iScience, 2020 Summary: The transcription factor BMAL1 is a core element of the circadian clock that contributes to cyclic control of genes transcribed by RNA polymerase II.
Marlene Cervantes +5 more
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RNA Biology, 2023 The main components of the essential cellular process of eukaryotic ribosome biogenesis are highly conserved from yeast to humans. Among these, the U3 Associated Proteins (UTPs) are a small subunit processome subcomplex that coordinate the first two ...
Mason A. McCool +8 more
doaj +2 more sources
Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome
Nature Communications, 2017 Excision of internal transcribed spacer 2 (ITS2) within eukaryotic pre-ribosomal RNA is essential for ribosome function. Here, the authors reconstitute the entire cycle of ITS2 processing in vitro using purified components, providing insights into the ...
Lisa Fromm +6 more
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SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing [PDF]
Nature Communications, 2016 SIRT7 is a protein deacetylase with important roles in rRNA synthesis, ribosome biogenesis and cell proliferation. Here the authors show a role of SIRT7 in rRNA maturation via deacetylation of U3-55k, a core component of the U3 snoRNP complex.
Sifan Chen +6 more
doaj +2 more sources
Human RPF1 and ESF1 in Pre-rRNA Processing and the Assembly of Pre-Ribosomal Particles: A Functional Study [PDF]
CellsRibosome biogenesis is essential for the functioning of living cells. In higher eukaryotes, this multistep process is tightly controlled and involves a variety of specialized proteins and RNAs.
Alexander Deryabin +6 more
doaj +2 more sources
The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. [PDF]
PLoS ONE, 2011 NIP7 is one of the many trans-acting factors required for eukaryotic ribosome biogenesis, which interacts with nascent pre-ribosomal particles and dissociates as they complete maturation and are exported to the cytoplasm.
Luis G Morello +9 more
doaj +2 more sources
Human RNase H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processing. [PDF]
PLoS ONE, 2013 Mammalian RNase H1 has been implicated in mitochondrial DNA replication and RNA processing and is required for embryonic development. We identified the mitochondrial protein P32 that binds specifically to human RNase H1, but not human RNase H2. P32 binds
Hongjiang Wu +4 more
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