Results 61 to 70 of about 925,381 (311)

A Model Study on the Dynamics of the Amino Acid Content in Micrometeoroids during Atmospheric Entry

open access: yesChemistry, 2020
A model for the survival of the amino acid content in micrometeorites and its possible transformations upon atmospheric entry is described. Since any organic species released in the atmosphere at high altitudes would exhibit a limited lifetime with ...
Carlo Canepa
doaj   +1 more source

Open questions in understanding life’s origins

open access: yesCommunications Chemistry, 2021
The chemical space of prebiotic chemistry is extremely large, while extant biochemistry uses only a few thousand interconnected molecules. Here we discuss how the connection between these two regimes can be investigated, and explore major outstanding ...
Christopher J. Butch   +3 more
doaj   +1 more source

Questions and Answers Related to the Prebiotic Production of Oligonucleotide Sequences from 3′,5′ Cyclic Nucleotide Precursors

open access: yesLife, 2021
Template-free nonenzymatic polymerization of 3′,5′ cyclic nucleotides is an emerging topic of the origin of life research. In the last ten years, a number of papers have been published addressing various aspects of this process.
Judit E. Šponer   +6 more
doaj   +1 more source

Prebiotic Chemistry that Could Not Not Have Happened. [PDF]

open access: yesLife (Basel), 2019
We present a direct route by which RNA might have emerged in the Hadean from a fayalite–magnetite mantle, volcanic SO2 gas, and well-accepted processes that must have created substantial amounts of HCHO and catalytic amounts of glycolaldehyde in the ...
Benner SA, Kim HJ, Biondi E.
europepmc   +2 more sources

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang   +11 more
wiley   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li   +8 more
wiley   +1 more source

Chemical Diversity of Metal Sulfide Minerals and Its Implications for the Origin of Life

open access: yesLife, 2018
Prebiotic organic synthesis catalyzed by Earth-abundant metal sulfides is a key process for understanding the evolution of biochemistry from inorganic molecules, yet the catalytic functions of sulfides have remained poorly explored in the context of the ...
Yamei Li, Norio Kitadai, Ryuhei Nakamura
doaj   +1 more source

Molecular Precursors of the RNA-World in Space: New Nitriles in the G+0.693−0.027 Molecular Cloud

open access: yesFrontiers in Astronomy and Space Sciences, 2022
Nitriles play a key role as molecular precursors in prebiotic experiments based on the RNA-world scenario for the origin of life. These chemical compounds could have been partially delivered to the young Earth from extraterrestrial objects, stressing the
Víctor M. Rivilla   +15 more
doaj   +1 more source

Atmospheric Prebiotic Chemistry and Organic Hazes [PDF]

open access: yesCurrent Organic Chemistry, 2013
Earth's atmospheric composition at the time of the origin of life is not known, but it has often been suggested that chemical transformation of reactive species in the atmosphere was a significant source of prebiotic organic molecules. Experimental and theoretical studies over the past half century have shown that atmospheric synthesis can yield ...
openaire   +2 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy