Results 141 to 150 of about 130,065,242 (295)

Assessment of the human epidermis model SkinEthic RHE for in vitro skin corrosion testing of chemicals according to new OECD TG 431

, 2006
Based on two successfully completed ECVAM validation studies for in vitro skin corrosion testing of chemicals, the National Co-ordinators of OECD Test Guideline Programme endorsed in 2002 two new test guidelines: TG 430 'Transcutaneous Electrical ...
Whittingham, A., Kandarova, H., Schmidt, E., Remmele, M., Guest, R., Spielmann, H., Warren, N., Traue, D., Gamer, A. O., Liebsch, M., Wever, B. de, Kaufmann, T., Wittmer, E., Rosdy, M., Genschow, E.   +14 more
core   +1 more source

Living Tissues by Design: The Rise of Hybrid Models in Biofabrication

Journal of Functional Biomaterials
Current in vitro tissue models struggle to recapitulate the structural, vascular, and mechanical complexity of human tissues, limiting their physiological relevance for disease modelling and preclinical testing. Self-organising three-dimensional cultures
Varvara Platania, Argyro Lamprou, Isaac Maximiliano Bugueno   +2 more
doaj   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

In vitro testing of cytotoxicity and hematotoxicity of drugs in development

, 2020
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Anna Ďurinová Supervisor: PharmDr. Lucie Hyršová, PhD.
Ďurinová, Anna
core  

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Report from the EPAA workshop : in vitro ADME in safety testing used by EPAA industry sectors

, 2011
There are now numerous in vitro and in silico ADME alternatives to in vivo assays but how do different industries incorporate them into their decision tree approaches for risk assessment, bearing in mind that the chemicals tested are intended for widely ...
KOCINA Iveta, Boehn, S. N., BLAAUBOER Bas J, Jagelavicius, M., S. Coecke, Schulz, T., Schroeder, K., KREYSA Joachim, L. Gombau, SCHULZ Thomas, WINKLER Petra, Toeroek, M., N. Jarrett, N. Alépée, K.D. Bremm, Hewitt, N. J., BREMM Klaus-Dieter, Whelan, M., GAMBOU Lourdes, Scheel, J., J. Scheel, JARRETT Nicholas, H. Steinkellner, J. Heylings, JAGELAVICIUS Marius, I. Kocina, Ketelslegers, H., COECKE Sandra, Poth, A., BUREK Christof, HUWYLER Joerg, Note, R., KETELSLEGERS Hans, Diembeck, W., T. Schulz, STEINKELLNER Hans, H. Ketelslegers, ALEPEE Natalie, NOTE Raymond, SCHEEL Julia, Blaauboer, B., HEYLINGS Jon, R. Note, M. Whelan, J. Huwyler, J.G.M. Bessems, M. Jaeger, SCHROEDER Klausrudolf, Koester, J., N.J. Hewitt, JAEGER Martina, Kocina, I., Steinkellner, H., DIEMBECK Walter, Coecke, S., Jaeger, M., WHELAN Maurice, POTH Albrecht, K. Schroeder, Rogiers, V., Radtke, M., P. Winkler, A. Poth, HEWITT Nicky, V. Rogiers, S.N. Boehn, BOEHN Susanne, RADTKE Martin, Burek, C., Heylings, J., Bessems, J. G., B. Blaauboer, M. Toeroek, ROGIERS Vera, Kreysa, J., Jarrett, N., Winkler, P., BESSEMS Jos, C. Burek, J. Kreysa, Huwyler, J., M. Jagelavicius, Alepee, N., KOESTER Johannes, Bremm, K. D., TOEROEK Michael, J. Koester, M. Radtke, Gombau, L., W. Diembeck   +89 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Emerging In Vitro Models for the Study of Infection and Pathogenesis of Pseudomonas aeruginosa and Testing of Antibacterial Agents

Several animal models have been developed to study infection strategies and pathogenesis of Pseudomonas aeruginosa. Some of these models are also used in preclinical and clinical research. However, these models are increasingly showing their limitations,
Ferrara, Silvia, Bertoni, Giovanni, Brignoli, Tarcisio, Brignoli T., Ferrara S., Bertoni G.   +5 more
core   +1 more source

Supplementary Table 5 from Molecular Characterization of the Pediatric Preclinical Testing Panel

, 2008
Supplementary Table 5 from Molecular Characterization of the Pediatric Preclinical Testing ...
Richard Gilbertson (1816618), Xiaoping Su (558134), C. Patrick Reynolds (14878661), Robert C. Seeger (7928399), Timothy J. Triche (10770898), Malcolm A. Smith (14878658), John M. Maris (7928381), Jeffrey Dome (110537), Richard Gorlick (4471), Richard B. Lock (12588187), Joseph Khoury (5395196), Doris Phelps (14910695), Geoffrey Neale (47090), Javed Khan (219271), Peter J. Houghton (143829), Christopher L. Morton (14897168), Henry S. Friedman (14930139)   +16 more
core   +1 more source