Results 131 to 140 of about 130,065,242 (295)

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source

An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing

British Journal of Cancer
Abstract Background Despite therapy advances, better solutions for refractory bladder cancer remain an unmet need. Human cell-based models may aid in better treatment translation. We introduce 3D-UHU-TU, a bladder cancer microtissue model which incorporates spheroids derived from low- and high ...
Benjamin O. Murray, Jinhui Gao, Laia Pasquina-Lemonche, Katherine Swarbrick, Guy Simpson, Mark A. Chambers, Hardev Pandha, Alex Freeman, Jennifer L. Rohn   +8 more
openaire   +3 more sources

AI‐Powered Framework for Evaluating Drug Efficacy for Three‐Dimensional In Vitro Cancer Models in Robot‐Assisted Production

Advanced Robotics Research, EarlyView.
An AI‐powered, robot‐assisted framework automatically produces, images, and analyzes 3D tumor spheroids to evaluate drug efficacy. Integrated modules handle spheroid formation, live/dead staining, brightfield imaging, and automated image analysis, including spheroid segmentation, viability and metrics to assess the drug treatment efficacy. The workflow
Dalia Mahdy, Jesus Nieves, Lukas Königer, Matthias Peindl, Fabio Erhard, Marc Möllmann, Anke Klingner, Markus Münig, Bibin Babu, Thomas Schwarz, Marco Metzger, Gudrun Dandekar, Maximiliane Wußmann, Jan Hansmann   +13 more
wiley   +1 more source

Preclinical Efficacy Testing of New Drug Candidates

, 2017
This is a review of the preclinical efficacy testing of new antituberculosis drug candidates. It describes existing dynamicin vitroandin vivomodels of antituberculosis chemotherapy and their utility in preclinical evaluations of promising new drugs and ...
Eric L. Nuermberger
core   +1 more source

Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation

Frontiers in Toxicology
The foreign body reaction (FBR), characterized by chronic inflammation and fibrotic capsule formation around implanted medical devices, remains a major cause in device-related complications.
Tom Meseberg, Susanne Kurz, Juliane Spohn   +2 more
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status

Journal of Experimental & Clinical Cancer Research
Background Head and neck cancers (HNC) represent an extremely heterogeneous group of diseases with a poorly predictable therapy outcome. Patient-derived tumor organoids (PDTO) offer enormous potential for individualized therapy testing and a better ...
Christian Issing, Constantin Menche, Mara Romero Richter, Mohammed H. Mosa, Jens von der Grün, Maximilian Fleischmann, Philipp Thoenissen, Ria Winkelmann, Tahmineh Darvishi, Andreas G. Loth, Shahram Ghanaati, Franz Rödel, Peter J. Wild, Christian H. Brandts, Timo Stöver, Henner F. Farin   +15 more
doaj   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

A combined approach to early detect in vitro drug-induced hemostatic changes in preclinical safety

, 2016
Early detection of drug-induced alterations of hemostasis is challenging. Drugs can affect different components of the Virchow's triad and measurement of plasmatic coagulation times lacks sensitivity.
Defontis, Myriam / MD, David Ledieu, Ledieu, David, Cote, Serge, Myriam Defontis, Defontis, Myriam, Serge Côté   +6 more
core   +1 more source

A Transnasal Endoscope for Robotically Assisted Gastroscopy

Advanced Robotics Research, EarlyView.
This work introduces a 4.25 mm diameter magnetically navigated transnasal endoscope for upper gastrointestinal (GI) screening and intervention. The system enables precise remote steering throughout the upper GI tract and is demonstrated through in vitro and in vivo experiments, including the robotic execution of preprogrammed retroflexions, trans ...
Alexandre Mesot, Michelle Mattille, Sean Lyttle, Shannon M. Chan, Philip W. Y. Chiu, Quentin Boehler, Bradley J. Nelson   +6 more
wiley   +1 more source