Results 111 to 120 of about 114,465,275 (302)

Next-Generation Cancer Models for Drug Testing: Recent Advances in Immunocompetent Microphysiological Systems

Future Pharmacology
The success of checkpoint inhibitors in improving cancer patient survival has demonstrated the therapeutic potential of immunotherapies. This advancement has reshaped oncology treatment and driven interest in harnessing immune modulation for a wider ...
Marlene Große, Martin Burchardt, Pedro Caetano Pinto   +2 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Green Nanotechnology Through Papain Nanoparticles: Preclinical in vitro and in vivo Evaluation of Imaging Triple-Negative Breast Tumors [PDF]

Aryel H Ferreira,1– 3,* Fábio LN Marques,4 Caroline C Real,5 Velaphi C Thipe,6,* Lucas F Freitas,1,2 Caroline SA Lima,1,2 Larissa Estessi de Souza,4 Mara S Junqueira,7 Daniele de Paula Faria,4 Gustavo HC Varca,1 Ademar B Lugão,1 Kattesh V Katti6 ...
de Paula Faria D, Lugão AB, Katti KV, Ferreira AH, Real CC, Thipe VC, Freitas LF, de Souza LE, Marques FLN, Lima CSA, Varca GHC, Junqueira MS   +11 more
core  

Gene transfer vectors targeted to human prostate cancer : do we need better preclinical testing systems? [PDF]

, 2010
Destruction of cancer cells by genetically modified viral and nonviral vectors has been the aim of many research programs. The ability to target cytotoxic gene therapies to the cells of interest is an essential prerequisite, and the treatment has always ...
Essand, M, Maitland, N, van Weerden, Wytske, Evans, Helen, Chambers, Karen F., Leadley, R, van Weerden, Wytske; id_orcid, Danielsson, Angelika,, Leadley, Regina, Maitland, Norman, Simpson-Holley, Martha, Georgopoulos, Lindsay, Evans, H, Danielsson, Angelika, Simpson-Holley, M, Kraaij, Robert, Chambers, Karen, Chambers, K, Essand, Magnus, Danielsson, A, Kraaij, Robert; id_orcid, de Ridder, Corrina, Bangma VERVALLEN, CH, Bangma, Chris H., Bangma, Chris, Georgopoulos, L, Essand, Magnus,   +26 more
core   +1 more source

Design and Verification of a Metaphyseal Filling Stem for Total Hip Arthroplasty Based on Novel Measurements of Proximal Femoral Anatomy

Arthroplasty Today
Background: Cementless metaphyseal filling stems rely on fixation in the medial-to-lateral and anterior-to-posterior (AP) planes. The purpose of this preclinical study was to develop Insignia, a new metaphyseal filling system to match the anatomy of the ...
Victor R. Carlson, MD, Bryan D. Springer, MD, Ahmad Faizan, PhD, Joshua Peterson, PhD, Don Imami, BS, Jeremy M. Gililland, MD   +5 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Strengthening preclinical testing to increase safety in surgical mesh

Inflammatory and fibrotic responses to polypropylene mesh led to the withdrawal of this practice for treatment of stress urinary incontinence and pelvic organ prolapse in women in some countries. Improved material testing has been urged.
MacNeil, S., Farr, N.T.H., Chapple, C.R., Workman, V.L., Rodenburg, C.   +4 more
core   +1 more source

Rethinking preclinical models for genetically engineered porcine red blood cell xenotransfusion

Cell Transplantation
Genetically engineered porcine red blood cells (pRBCs) are emerging as a potential supplementary source of oxygen-carrying cells for transfusion medicine. Triple-knockout (TKO) pigs lacking major carbohydrate xenoantigens, including Gal, Neu5Gc, and Sd(a)
Xiayu Lei MD, Hidetaka Hara MD, PhD, Tao Li MD, PhD, Yi Wang MD, PhD   +3 more
doaj   +1 more source

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Frontiers in Pharmacology, 2019
Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclinical ...
Brian D. Guth, Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Alexandre J. S. Ribeiro, Tanja Zabka, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge   +14 more
doaj   +1 more source