Results 101 to 110 of about 130,065,242 (295)

Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation.

PLoS ONE, 2011
Polo-like kinases (PLKs) play an important role in cell cycle progression, checkpoint control and mitosis. The high mitotic index and chromosomal instability of advanced cancers suggest that PLK inhibitors may be an attractive therapeutic option for ...
Douglas W McMillin, Jake Delmore, Joseph Negri, Melissa Ooi, Steffen Klippel, Chandrasekhar V Miduturu, Nathanael S Gray, Paul G Richardson, Kenneth C Anderson, Andrew L Kung, Constantine S Mitsiades   +10 more
doaj   +1 more source

Human atrium-sized in vitro modelling of atrial fibrillation: a new experimental scale for preclinical therapeutic testing [PDF]

Europace
Abstract Background Atrial size strongly influences atrial fibrillation (AF) development, maintenance, and therapeutic outcome, including pharmacological cardioversion. Despite this, preclinical research relies heavily on models considerably smaller than the human atrium, such as cell-based and
Nobacht, A, De Coster, T, Deng, S, Zhang, J, Dekker, S O, Den Ouden, B L, Rivaud, M R, Wijnmalen, A P, Trines, S A, Portero, V, Boukens, B J, De Vries, A A F, Pijnappels, D A   +12 more
europepmc   +3 more sources

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Preclinical evaluation

, 2018
Mechanical circulatory and respiratory support systems are classified as high-risk devices that support or sustain human life by regulatory authorities worldwide and as such are required to undergo rigorous preclinical evaluation prior to adaption as ...
Dasse, Kurt, Dasse, K, Pauls, JP, Bartnikowski, Nicole, Jo P. Pauls, Bartnikowski, N, Lim, E, Pauls, Jo P., Jansen, So-Hyun, So-Hyun Jansen, Lim, Einly, Einly Lim, Nicole Bartnikowski, Jansen, SH, Kurt Dasse   +14 more
core   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Next-Generation Cancer Models for Drug Testing: Recent Advances in Immunocompetent Microphysiological Systems

Future Pharmacology
The success of checkpoint inhibitors in improving cancer patient survival has demonstrated the therapeutic potential of immunotherapies. This advancement has reshaped oncology treatment and driven interest in harnessing immune modulation for a wider ...
Marlene Große, Martin Burchardt, Pedro Caetano Pinto   +2 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Biodegradable Conductors for Implantable and Wearable Transient Bioelectronics

Advanced Functional Materials, EarlyView.
Biodegradable conductors are essential building blocks for transient bioelectronics, enabling temporary sensing, stimulation, and energy transfer while eliminating the need for device retrieval. This review summarizes biodegradable metals, conducting polymers, ionic conductors, and conductive composites, highlighting degradation mechanisms, material ...
Yicheng Zhu, Yijun Liu, Naoji Matsuhisa
wiley   +1 more source

In vitro testing of substances with potential therapeutic effect

, 2017
Bakalářská práce je věnována in vitro metodám využívající se pro testování cytotoxicity, což je nezbytnou součástí výzkumu nového léčiva. Ten zahrnuje preklinické a klinické studie in vivo, ale také studie počítačové simulace in silico. Práce je zaměřena
Stodůlková, Iveta
core   +1 more source