Results 91 to 100 of about 130,065,242 (295)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis

, 2015
Zhenhua Huang,1 Heran Li,1 Qian Zhang,2 Xiaojuan Tan,2 Fangzheng Lu,1 Hongzhuo Liu,1 Sanming Li11School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 2KBP BioSciences Co.
Liu H, Li H, Tan X, Li S, Huang Z, Lu F, Zhang Q   +6 more
core  

In vitro antifungal susceptibility testing.

, 2022
In vitro antifungal susceptibility testing.
Hengyu Deng (12127249), Hua Wu (2707), Dingxia Shen (425821), Lifeng Wang (121568), Xinying Xue (3611864), Xuelei Zang (10153523), Yemei Huang (12127246), Meng Zhou (105903), Ningxin Wu (6949211), Weixin Ke (12127243)   +9 more
core   +1 more source

Development of an in vitro three-layered skin wound healing model for pre-clinical testing

Current Directions in Biomedical Engineering
Skin wound healing involves many cell types in a stepwise process of tissue regeneration. Reepithelialization is an essential characteristic of successful healing.
Nowakowski Sophia, Schmidt Freia F., Kluger Petra J.   +2 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Micrometastasis-derived models enable drug testing for early-stage, high-risk melanoma patients

EMBO Molecular Medicine
Relapse in melanoma after targeted or immune therapy necessitates the rapid identification of effective alternatives. To address this gap, we investigated whether the timely generation of preclinical models for functional drug testing could reveal ...
Kathrin Weidele, Christian Werno, Steffi Treitschke, Catherine Botteron, Martin Hoffmann, Sebastian Scheitler, Lukas Wöhrl, Zbigniew Czyz, Giancarlo Feliciello, Florian Weber, Adithi Ravikumar Varadarajan, Jens Warfsmann, Silvia Materna-Reichelt, Marie Katzer, Laura Schreieder, Parvaneh Mohammadi, Hedayatollah Hosseini, Kamran Honarnejad, Sebastian Haferkamp, Melanie Werner-Klein, Christoph A Klein   +20 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Next generation organoid engineering to replace animals in cancer drug testing

, 2023
Cancer therapies have several clinical challenges associated with them, namely treatment toxicity, treatment resistance and relapse. Due to factors ranging from patient profiles to the tumour microenvironment (TME), there are several hurdles to overcome ...
Simoes, Davina Camargo Madeira, Turner, Jasmin E., Jasmin E. Turner, Roben Ger Gieling, Todd, Xanthea, Turner, Jasmin E, Gerrit Hilgen, Xanthea Todd, Davina Camargo Madeira Simoes, Todryk, Stephen, Gieling, Roben Ger, Hockney, Sean, Sean Hockney, Deepali Pal, Pal, Deepali, Stephen Todryk, Jessica Parker, Parker, Jessica, Hilgen, Gerrit   +18 more
core   +1 more source

Advanced tissue technologies of blood-brain barrier organoids as high throughput toxicity readouts in drug development

Heliyon
Recent advancements in engineering Complex in vitro models (CIVMs) such as Blood-brain barrier (BBB) organoids offer promising platforms for preclinical drug testing.
Luisa Bell, Claire Simonneau, Chiara Zanini, Elena Kassianidou, Christelle Zundel, Rachel Neff, Bernd Steinhuber, Marco Tecilla, Alex Odermatt, Roberto Villaseñor, Nadine Stokar-Regenscheit   +10 more
doaj   +1 more source