Results 91 to 100 of about 114,465,275 (302)

Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells

Molecular Therapy: Methods & Clinical Development, 2016
Gene therapy for HIV-1 infection is a promising alternative to lifelong combination antiviral drug treatment. Chemokine receptor 5 (CCR5) is the coreceptor required for R5-tropic HIV-1 infection of human cells. Deletion of CCR5 renders cells resistant to
David L DiGiusto, Paula M Cannon, Michael C Holmes, Lijing Li, Anitha Rao, Jianbin Wang, Gary Lee, Philip D. Gregory, Kenneth A Kim, Samuel B Hayward, Kathleen Meyer, Colin Exline, Evan Lopez, Jill Henley, Nancy Gonzalez, Victoria Bedell, Rodica Stan, John A Zaia   +17 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis

, 2015
Zhenhua Huang,1 Heran Li,1 Qian Zhang,2 Xiaojuan Tan,2 Fangzheng Lu,1 Hongzhuo Liu,1 Sanming Li11School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 2KBP BioSciences Co.
Liu H, Li H, Tan X, Li S, Huang Z, Lu F, Zhang Q   +6 more
core  

Report from the EPAA workshop : in vitro ADME in safety testing used by EPAA industry sectors [PDF]

, 2011
There are now numerous in vitro and in silico ADME alternatives to in vivo assays but how do different industries incorporate them into their decision tree approaches for risk assessment, bearing in mind that the chemicals tested are intended for widely ...
KOCINA Iveta, Boehn, S. N., BLAAUBOER Bas J, Jagelavicius, M., S. Coecke, Schulz, T., Schroeder, K., KREYSA Joachim, L. Gombau, SCHULZ Thomas, WINKLER Petra, Toeroek, M., N. Jarrett, N. Alépée, K.D. Bremm, Hewitt, N. J., BREMM Klaus-Dieter, Whelan, M., GAMBOU Lourdes, Boehn, S.N., Scheel, J., J. Scheel, JARRETT Nicholas, H. Steinkellner, J. Heylings, JAGELAVICIUS Marius, I. Kocina, Ketelslegers, H., COECKE Sandra, Poth, A., BUREK Christof, HUWYLER Joerg, Note, R., KETELSLEGERS Hans, Diembeck, W., T. Schulz, STEINKELLNER Hans, H. Ketelslegers, ALEPEE Natalie, NOTE Raymond, SCHEEL Julia, Blaauboer, B., HEYLINGS Jon, R. Note, M. Whelan, J. Huwyler, J.G.M. Bessems, M. Jaeger, SCHROEDER Klausrudolf, Koester, J., N.J. Hewitt, JAEGER Martina, Kocina, I., Steinkellner, H., DIEMBECK Walter, Coecke, S., Jaeger, M., WHELAN Maurice, POTH Albrecht, K. Schroeder, Rogiers, V., Radtke, M., P. Winkler, Hewitt, N.J., A. Poth, HEWITT Nicky, V. Rogiers, S.N. Boehn, BOEHN Susanne, RADTKE Martin, Burek, C., Heylings, J., Bessems, J. G., B. Blaauboer, Bessems, J.G.M., M. Toeroek, ROGIERS Vera, Kreysa, J., Jarrett, N., Winkler, P., BESSEMS Jos, C. Burek, J. Kreysa, Huwyler, J., M. Jagelavicius, Alepee, N., KOESTER Johannes, Bremm, K. D., Bremm, K.D., TOEROEK Michael, J. Koester, M. Radtke, Gombau, L., W. Diembeck   +93 more
core   +1 more source

Development of an in vitro three-layered skin wound healing model for pre-clinical testing

Current Directions in Biomedical Engineering
Skin wound healing involves many cell types in a stepwise process of tissue regeneration. Reepithelialization is an essential characteristic of successful healing.
Nowakowski Sophia, Schmidt Freia F., Kluger Petra J.   +2 more
doaj   +1 more source

Preclinical models in radiation oncology

Radiation Oncology, 2012
As the incidence of cancer continues to rise, the use of radiotherapy has emerged as a leading treatment modality. Preclinical models in radiation oncology are essential tools for cancer research and therapeutics.
Kahn Jenna, Tofilon Philip J, Camphausen Kevin   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation.

PLoS ONE, 2011
Polo-like kinases (PLKs) play an important role in cell cycle progression, checkpoint control and mitosis. The high mitotic index and chromosomal instability of advanced cancers suggest that PLK inhibitors may be an attractive therapeutic option for ...
Douglas W McMillin, Jake Delmore, Joseph Negri, Melissa Ooi, Steffen Klippel, Chandrasekhar V Miduturu, Nathanael S Gray, Paul G Richardson, Kenneth C Anderson, Andrew L Kung, Constantine S Mitsiades   +10 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source