Results 251 to 260 of about 114,465,275 (302)

Emerging organoids and organoids-on-chip platforms for translational development of antibody‒drug conjugates and next-generation bioconjugates. [PDF]

Acta Pharm Sin B
Hu Z, Liao Y, Niu M, Kong Z, Vankelecom H, Cheng J, Deleidi M, Li C, Jiang Z, Bian S, Wang Q.   +10 more
europepmc   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Preclinical Models of Rare Corneal and Ocular Surface Diseases: a Comprehensive Narrative Review. [PDF]

Ophthalmol Ther
Lecchi EAL, Dashti A, Frutos-Rincón L, Palombella S, Pederzolli M, Gallar J, Lagali N, Ferrari G.   +7 more
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Vitreous Substitutes in Vitreoretinal Surgery: From Native Vitreous Physiology to Bioengineered Experimental Replacements. [PDF]

J Funct Biomater
Avitabile A, Cannizzaro L, Rusciano D.
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Precision bacteriophage therapy for multidrug-resistant recurrent urinary tract infections: From biological rationale to clinical translation in Taiwan. [PDF]

Tzu Chi Med J
Lin LC, Kuo HC, Lin NT.
europepmc   +1 more source

(In Vitro Cellular&Developmental Biology Plant,35:061-069)A protocol for efficient transformation and regeneration of Carica papaya L.

, 2014
Souza, M., Gonsalves, D., Cai, W., Gonsalves, C., Zhu, H. Y., Jan, Fuh-Jyh, Fermin, G., Sarindu, N., Tennant, P.   +8 more
core  

Hyperlipidemia Intervention from Medicine-Food Homologous Plants: A Review of Regulatory Status, Processing Techniques, and Lipid-Lowering Mechanisms. [PDF]

Biology (Basel)
Chen J, Liu D, Zhu P, Liu L.
europepmc   +1 more source

Ciliation and mucus secretion in an in vitro model of nasal mucosa based on CI-pNaEC cell line for preclinical drug testing

European Journal of Pharmaceutics and Biopharmaceutics
Leonie Pia Isabelle Klintz, Stephan Reichl   +1 more
openaire   +1 more source