Results 261 to 270 of about 130,065,242 (295)
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49. Combined treatments with Hadrontherapy – in vitro tests and preclinical approach
Physica Medica, 2018Purpose Glioblastoma multiforme (GBM) is the most aggressive types of central nervous system tumors. The aim of the project is to validate an innovative molecule developed by Lead Discovery Siena [LDS] showing inhibitory activity against Src kinases to be associated with proton therapy treatments.
G. Russo +14 more
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Journal of Neurosurgery, 2020
OBJECTIVEThe management of patients with aneurysmal subarachnoid hemorrhage (aSAH) remains a highly demanding challenge in critical care medicine. Despite all efforts, the calcium channel antagonist nimodipine remains the only drug approved for improving outcomes after aSAH.
Simon H, Bayerl +6 more
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OBJECTIVEThe management of patients with aneurysmal subarachnoid hemorrhage (aSAH) remains a highly demanding challenge in critical care medicine. Despite all efforts, the calcium channel antagonist nimodipine remains the only drug approved for improving outcomes after aSAH.
Simon H, Bayerl +6 more
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Current Pharmaceutical Design, 2012
Cancer remains one of the leading causes of death in the Western world. Despite bold advances in therapeutic oncology, new drug development is infamously ineffective due to the lack of predictive in vitro models. Most patients that suffer from cancer do not die from the primary tumor but due to the development of metastases.
Theodore L, Drell +2 more
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Cancer remains one of the leading causes of death in the Western world. Despite bold advances in therapeutic oncology, new drug development is infamously ineffective due to the lack of predictive in vitro models. Most patients that suffer from cancer do not die from the primary tumor but due to the development of metastases.
Theodore L, Drell +2 more
openaire +2 more sources
Plasma Processes and Polymers, 2022
AbstractBone metastasis is a frequent occurrence following breast cancer. The bone‐tumor microenvironment is heterogeneous and complicated to recapitulate. The development of new chemotherapeutics is ineffective partly due to a lack of precise in vitro tissue models.
Mansoureh Mohseni Garakani +4 more
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AbstractBone metastasis is a frequent occurrence following breast cancer. The bone‐tumor microenvironment is heterogeneous and complicated to recapitulate. The development of new chemotherapeutics is ineffective partly due to a lack of precise in vitro tissue models.
Mansoureh Mohseni Garakani +4 more
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Surgical Endoscopy, 2016
Electromechanical power morcellation is an important tool of modern laparoscopy. Recent reports on the spread of previously undetected malignancy by power morcellation indicate the need for additional protective devices to reduce this risk. We conducted a study to obtain the first data concerning the safety of an endobag with three closable ports ...
Michael, Anapolski +5 more
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Electromechanical power morcellation is an important tool of modern laparoscopy. Recent reports on the spread of previously undetected malignancy by power morcellation indicate the need for additional protective devices to reduce this risk. We conducted a study to obtain the first data concerning the safety of an endobag with three closable ports ...
Michael, Anapolski +5 more
openaire +2 more sources
Lab on a Chip, 2020
Selected skin MPS features desired to advance further adoption within the pharmaceutical industry.
Rhiannon N. Hardwick +6 more
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Selected skin MPS features desired to advance further adoption within the pharmaceutical industry.
Rhiannon N. Hardwick +6 more
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Skin Pharmacology and Physiology
Background: This review summarizes published literature on in vitro and ex vivo test methods for preclinical evaluation of wound care products. There is currently no guidance from, e.g., authorities on how wound care products, especially antimicrobial wound care products, should be assessed regarding their cell toxic effects and their antimicrobial ...
Katharina Schuhladen +4 more
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Background: This review summarizes published literature on in vitro and ex vivo test methods for preclinical evaluation of wound care products. There is currently no guidance from, e.g., authorities on how wound care products, especially antimicrobial wound care products, should be assessed regarding their cell toxic effects and their antimicrobial ...
Katharina Schuhladen +4 more
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In-vitro and preclinical testing of bacillus subtilis UBBS-14 probiotic in rats shows no toxicity
Toxicology ResearchAbstract Introduction Probiotics made from Bacillus subtilis provide a wide spread of health benefits, particularly in the treatment of diarrhea and gastrointestinal problems. Herein, we employed in vitro and in vivo paradigms to assess the potential adverse effects and toxicity of B. subtilis UBBS-14.
Ankit Negi +4 more
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Contribution of "in vitro" assays to preclinical and premarketing testing in immunotoxicology.
Central European journal of public health, 1994An attempt to replace the "in vivo" testing by "in vitro" exposure of cells to drugs is discussed from the point of view of the limitations of these artificial test conditions. The critical reminders are evaluated, the most important ones being the pharmacokinetics, pharmacodynamics and metabolism of drugs in the body what may be a cause of the ...
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2019
Given the worldwide prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), and a substantial proportion of simple steatosis patients progressing to Non-Alcoholic Steatohepatitis (NASH), a condition associated with liver inflammation, and, further, to cirrhosis and end-stage liver failure, the development of in vitro models for NAFLD is warranted ...
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Given the worldwide prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), and a substantial proportion of simple steatosis patients progressing to Non-Alcoholic Steatohepatitis (NASH), a condition associated with liver inflammation, and, further, to cirrhosis and end-stage liver failure, the development of in vitro models for NAFLD is warranted ...
openaire +1 more source