Results 111 to 120 of about 518,230 (247)

Simplified and accessible [¹⁸ F]F-AraG synthesis procedure for preclinical PET. [PDF]

J Labelled Comp Radiopharm, 2022
Högnäsbacka AA, Cortés González MA, Halldin C, Schou M.   +3 more
europepmc   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Comparison of scandium-44 g with other PET radionuclides in pre-clinical PET phantom imaging

EJNMMI Physics, 2019
Purpose The decay characteristics of radionuclides in PET studies can impact image reconstruction. 44gSc has been the topic of recent research due to potential theranostic applications and is a promising radiometal for PET imaging.
Simon Ferguson, Hans-Sonke Jans, Melinda Wuest, Terence Riauka, Frank Wuest   +4 more
doaj   +1 more source

Preclinical PET Imaging and Toxicity Study of a ⁶⁸Ga-Functionalized Polymeric Cardiac Blood Pool Agent. [PDF]

Pharmaceutics, 2023
Saatchi K, Bénard F, Hundal N, Grimes J, Shcherbinin S, Pourghiasian M, Brooks DE, Celler A, Häfeli UO.   +8 more
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Perfomance analysis of a small animal PET scanner using 68Ga Isotope

Brazilian Journal of Radiation Sciences
In recent years, the use of PET scanners for small animals in preclinical research has been growing in Brazil, due to this fact it is essential to have a quality assurance program to ensure the good performance of these scanners or indicate the need for
Victória Garcia Moreira, Anna Clara Moreira Silva, Rodrigo Modesto Gadelha Gontijo, Andréa Vidal Ferreira   +3 more
doaj   +1 more source

Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am. [PDF]

Cancers (Basel), 2023
Bulat F, Hesse F, Attili B, Solanki C, Mendichovszky IA, Aigbirhio F, Leeper FJ, Brindle KM, Neves AA.   +8 more
europepmc   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

PET in neurotherapeutic discovery and development

Neurotherapeutics
Positron emission tomography (PET) is a highly sensitive, quantitative imaging technique that can track sub-nanomolar quantities of positron-emitting radionuclides throughout the body.
Melissa Chassé, Neil Vasdev
doaj   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source