Results 111 to 120 of about 59,711 (283)

Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration.

, 2013
Understanding brain reserve in preclinical stages of neurodegenerative disorders allows determination of which brain regions contribute to normal functioning despite accelerated neuronal loss.
Scheller, Elisa, Peter, J, Peter, Jessica, Scheller, E., Peter, J., Abdulkadir, Ahmed, Frackowiak, Richard S. J., Frackowiak, R.S., Klöppel, Stefan, Tabrizi, S.J., Frackowiak, Richard S.J., Abdulkadir, A, Tabrizi, SJ, Frackowiak, RS, Scheller, E, Klöppel, S., Tabrizi, Sarah J., Abdulkadir, A., Klöppel, S   +18 more
core   +1 more source

Effects of high photon fluence rate from therapeutic radionuclides on preclinical and clinical PET systems

, 2016
Tumor response in radionuclide therapy can be monitored with PET/CT and/or PET/MR. A high background photon fluence from a therapy radionuclide may influence both image quality and quantification, when imaging is performed intra-therapeutically, i.e ...
Dahlbom, Magnus, Axelsson, Johan, Tran, Thuy, Mellhammar, Emma, Strand, Sven Erik   +4 more
core   +2 more sources

Imaging of pain using positron emission tomography

iRADIOLOGY
Positron emission tomography (PET) is a noninvasive molecular imaging technique that utilizes biologically active radiolabeled compounds to image biochemical processes.
Yu‐Peng Zhou, Lauren L. Zhang, Yang Sun, Pedro Brugarolas   +3 more
doaj   +1 more source

Initial PET performance evaluation of a preclinical insert for PET/MRI with digital SiPM technology

Physics in Medicine and Biology, 2016
Published by IOP Publ ...
Schug, David, Lerche, Christoph, Weissler, Bjoern, Gebhardt, Pierre, Goldschmidt, Benjamin, Wehner, Jakob, Dueppenbecker, Peter Michael, Salomon, Andre, Hallen, Patrick, Kiessling, Fabian, Schulz, Volkmar   +10 more
openaire   +6 more sources

In Vivo Microplastic Detection With Photoacoustic Imaging

Advanced Science, EarlyView.
ABSTRACT Microplastics are posing an escalating threat to both ecological systems and human health. Yet, current methods for investigating their bioaccumulation are highly invasive, requiring destructive analysis of ex vivo tissues via mass spectrometry, dye labelling, or Raman microspectroscopy.
Joseph C. Bear, Olumide Ogunlade, Jayvian Mavi, Emily J. Deniszczyc, Daolong Chen, Heeva Javaheri, Paul Beard, Mark F. Lythgoe, Daniel J. Stuckey, P. Stephen Patrick   +9 more
wiley   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Quantitative in vivo Cherenkov luminescence imaging and dosimetry of 86Y-NM600

EJNMMI Physics
Purpose The rapid expansion of radiopharmaceutical therapy (RPT) development demands scalable preclinical dosimetry methods. While PET and SPECT remain the gold standards, their low throughput and high cost limit large-cohort studies.
Campbell D. Haasch, Malick Bio Idrissou, Sydney Jupitz, Aubrey Parks, Reinier Hernandez, Brian W. Pogue, Bryan P. Bednarz   +6 more
doaj   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

The Down Syndrome Biomarker Initiative (DSBI) Pilot: Proof of Concept for Deep Phenotyping of Alzheimer’s Disease Biomarkers in Down Syndrome

Frontiers in Behavioral Neuroscience, 2015
To gain further knowledge on the preclinical phase of AD, we sought to characterize cognitive performance, volumetric MRI, amyloid PET, FDG PET, retinal amyloid, and plasma biomarkers in a cohort of non-demented adults with Down Syndrome (DS).
Michael eRafii, Hannah eWishnek, James eBrewer, Michael eDonohue, Seth eNess, William eMobley, Paul eAisen, Robert eRissman   +7 more
doaj   +1 more source

Applications of PET imaging in the preclinical stage of drug development.

Folia Pharmacologica Japonica, 2010
PET（Positron Emission Tomography: 陽電子断層画像装置）は，生体内分子ターゲットを特異的に認識するポジトロン標識化合物の生体内動態・分布を非侵襲的に体外から計測する事で，生体内機能を画像化・定量化できる分子イメージング法として，実験動物を対象にした基礎研究からヒト患者を対象にした臨床研究まで，幅広く応用されてきた．例えば，がん細胞に高い集積を示すグルコースの類縁物質である［18F］FDGを用いた「がん検診」に活用されている．創薬研究の分野では，膨大な開発期間と費用を要する医薬品開発の効率化のため，これらのPETの優れた特性を利用しようという試みが，既に欧米では1990年代初頭から始まっており，この数年ようやく国内にも広がってきた．本稿では ...
openaire   +3 more sources