Results 91 to 100 of about 55,685 (249)

Bio‐Inspired Biopolymeric Implantable Platform for Localized and Sustained Drug Delivery in Solid Tumor Treatment

Advanced Functional Materials, EarlyView.
A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia, Constantine Vogiatzis, Alejandra Planells‐Devesa, Emre Dikici, Caroline Vieira Maluf, Vasudev Vivekanand Nayak, Paulo G. Coelho, Lukasz Witek, Alicia Bilbao, Daniel Bilbao, Prasoon Mohan, Sapna Deo, Sylvia Daunert   +12 more
wiley   +1 more source

Gradient‐Conductivity Architecture Enables Synchronous Enhancement of Sensitivity and Detection Range in Multifunctional All‐Paper Sensors

Advanced Functional Materials, EarlyView.
A gradient‐engineered all‐paper sensor is fabricated by integrating MXene and in situ grown AgNPs within hierarchical cellulose networks. The device breaks the sensitivity–detection range trade‐off through cascaded conductive pathways, enabling ultrahigh pressure sensitivity, humidity–pressure decoupled dual‐mode sensing, and outstanding EMI shielding,
Ao Li, Jun Xu, Dezhong Xu, Zhaohui Zhang, Jiyi Li, Daxian Cao, Kefu Chen, Mizi Fan   +7 more
wiley   +1 more source

The Down Syndrome Biomarker Initiative (DSBI) Pilot: Proof of Concept for Deep Phenotyping of Alzheimer’s Disease Biomarkers in Down Syndrome

Frontiers in Behavioral Neuroscience, 2015
To gain further knowledge on the preclinical phase of AD, we sought to characterize cognitive performance, volumetric MRI, amyloid PET, FDG PET, retinal amyloid, and plasma biomarkers in a cohort of non-demented adults with Down Syndrome (DS).
Michael eRafii, Hannah eWishnek, James eBrewer, Michael eDonohue, Seth eNess, William eMobley, Paul eAisen, Robert eRissman   +7 more
doaj   +1 more source

Applications of PET imaging in the preclinical stage of drug development.

Folia Pharmacologica Japonica, 2010
PET（Positron Emission Tomography: 陽電子断層画像装置）は，生体内分子ターゲットを特異的に認識するポジトロン標識化合物の生体内動態・分布を非侵襲的に体外から計測する事で，生体内機能を画像化・定量化できる分子イメージング法として，実験動物を対象にした基礎研究からヒト患者を対象にした臨床研究まで，幅広く応用されてきた．例えば，がん細胞に高い集積を示すグルコースの類縁物質である［18F］FDGを用いた「がん検診」に活用されている．創薬研究の分野では，膨大な開発期間と費用を要する医薬品開発の効率化のため，これらのPETの優れた特性を利用しようという試みが，既に欧米では1990年代初頭から始まっており，この数年ようやく国内にも広がってきた．本稿では ...
openaire   +3 more sources

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze, Hannah J. Brien, Kevin C. Corn, Marjan Rafat, Jonathan M. Brunger   +7 more
wiley   +1 more source

Feasibility of in vivo small animal imaging using a clinical total-body PET/CT system

EJNMMI Physics
Background Clinical PET scanners have long been explored for preclinical imaging, but limited spatial resolution and sensitivity have restricted their use for preclinical studies.
Julia G. Mannheim, Wenhong Lan, Maurizio Conti, Franziska Siedler, Marcel A. Krueger, Kristina Herfert, Christian la Fougère, Fabian P. Schmidt   +7 more
doaj   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2016
Introduction Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated
Benjamin M. Kandel, Brian B. Avants, James C. Gee, Corey T. McMillan, Guray Erus, Jimit Doshi, Christos Davatzikos, David A. Wolk, Alzheimer's Disease Neuroimaging Initiative   +8 more
doaj   +1 more source

Understanding the importance of quality control and quality assurance in preclinical PET/CT imaging. [PDF]

EJNMMI Phys, 2022
McDougald WA, Mannheim JG.
europepmc   +1 more source