Results 71 to 80 of about 518,230 (247)

PET Imaging in Preclinical Anti-Aβ Drug Development

, 2022
Positron emission tomography (PET), a medical imaging technique allowing for studies of the living human brain, has gained an important role in clinical trials of novel drugs against Alzheimer’s disease (AD).
Syvänen, Stina,, Faresjö, Rebecca, Xiong, Mengfei,, Roshanbin, Sahar, Bonvicini, Gillian, Syvänen, Stina, Bonvicini, Gillian,, Gustavsson, Tobias,, Aguilar, Ximena, Eriksson, Jonas,, Julku, Ulrika, Meier, Silvio R., Sehlin, Dag, Faresjö, Rebecca,, Schlein, Eva, Schlein, Eva,, Gustavsson, Tobias, Sehlin, Dag,, Eriksson, Jonas, Aguilar, Ximena,, Meier, Silvio R.,, Roshanbin, Sahar,, Xiong, Mengfei, Julku, Ulrika,   +23 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

High Dose MicroCT Does Not Contribute Toward Improved MicroPET/CT Image Quantitative Accuracy and Can Limit Longitudinal Scanning of Small Animals

Frontiers in Physics, 2017
Obtaining accurate quantitative measurements in preclinical Positron Emission Tomography/Computed Tomography (PET/CT) imaging is of paramount importance in biomedical research and helps supporting efficient translation of preclinical results to the ...
Wendy A. McDougald, Richard Collins, Mark Green, Adriana A. S. Tavares   +3 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Microglial activation is raised in preclinical Alzheimer’s disease and associated with covert memory impairment

Frontiers in Dementia
BackgroundAlzheimer’s disease (AD) is a continuum between normal health and dementia with a long preclinical phase, during which AD pathologies start to emerge, but where there are not yet any overt symptoms.
Pernille Louise Kjeldsen, Pernille Louise Kjeldsen, Pernille Louise Kjeldsen, Lasse Stensvig Madsen, Lasse Stensvig Madsen, Peter Parbo, Peter Parbo, Rola Ismail, Joel Fredrik Astrup Aanerud, Malene Kaasing, Malene Kaasing, Malene Flensborg Damholdt, Malene Flensborg Damholdt, Simon Fristed Eskildsen, Simon Fristed Eskildsen, Leif Østergaard, Leif Østergaard, David James Brooks, David James Brooks, David James Brooks   +19 more
doaj   +1 more source

Clinical applications of PET/MRI: current status and future perspectives

Diagnostic and Interventional Radiology, 2014
Fully integrated positron emission tomography (PET)/magnetic resonance imaging (MRI) scanners have been available for a few years. Since then, the number of scanner installations and published studies have been growing.
Felix Nensa, Karsten Beiderwellen, Philipp Heusch, Axel Wetter   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Preclinical investigations and first-in-human application of 152Tb-PSMA-617 for PET/CT imaging of prostate cancer

EJNMMI Research, 2019
Background For almost a decade, terbium radioisotopes have been explored for their potential theragnostic application in nuclear medicine: 152Tb and 155Tb are the radioisotopes identified for PET or SPECT imaging, while 149Tb and 161Tb have suitable ...
Cristina Müller, Aviral Singh, Christoph A. Umbricht, Harshad R. Kulkarni, Karl Johnston, Martina Benešová, Stefan Senftleben, Dirk Müller, Christiaan Vermeulen, Roger Schibli, Ulli Köster, Nicholas P. van der Meulen, Richard P. Baum   +12 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source