Results 81 to 90 of about 518,230 (247)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

CHAPTER 18. Preclinical Hybrid MR-PET Scanner Hardware

, 2018
The use of preclinical imaging in research spans several decades and developments in the field are continuing in a number of directions, with research using simultaneous hybrid magnetic resonance-positron emission tomography (MR-PET) systems at the ...
Felder, J., Lerche, Christoph, Choi, C.-H.   +2 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies [PDF]

Ann Clin Transl Neurol
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Corbali O, Menon P, Corbali H, Jagannathan R, Levey A.   +4 more
europepmc   +2 more sources

Cognitive Reserve Associated with FDG-PET in Preclinical Alzheimer Disease [PDF]

, 2013
OBJECTIVE: To examine the effect of education (a surrogate measure of cognitive reserve) on FDG-PET brain metabolism in elderly cognitively healthy (HC) subjects with preclinical Alzheimer disease (AD).
Insel, Philip S, Stern, Yaakov, Insel, Philip S., Ewers, Michael, Weiner, Michael W., Weiner, Michael W   +5 more
core   +1 more source

Alzheimer's Disease Biomarkers Measured by Capillary Blood Collection Versus Venous Plasma and Cerebrospinal Fluid

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Blood biomarkers are increasingly critical for non‐invasive Alzheimer's Disease (AD) diagnostics and research but typically require on‐site processing. Remote point‐of‐care collection methods could enhance biomarker testing in clinical and research settings.
Sara Ho, Ziling Shen, Alexandria Lewis, Megha Patel, Anny Zheng, Gianna Proscino, Thaovy Ho, Jiangxia Wang, Marilyn Albert, Abhay Moghekar   +9 more
wiley   +1 more source

Preclinical PET data

, 2019
An open preclinical PET dataset. This dataset has been measured with the preclinical Siemens Inveon PET machine. The measured target is a (naive) rat with an injected dose of 21.4 MBq of FDG. The injection was done intravenously (IV) to the tail vein. No
Jokivarsi, Kimmo (8336667), Jokivarsi, Kimmo, Wettenhovi, Ville-Veikko, Wettenhovi, Ville-Veikko (7578266)   +3 more
core   +1 more source

Consumer Resistance in the Pet Marketplace [PDF]

This study draws on Cherrier’s (2008) concept of consumer-resistant identities together with the work of Beverland, Farelly and Lim (2008) on the dark side of pet ownership to shed light on consumer resistance in the context of the pet marketplace.
McEachern, Morven G., Cheetham, Fiona
core   +3 more sources

Imaging of pain using positron emission tomography

iRADIOLOGY
Positron emission tomography (PET) is a noninvasive molecular imaging technique that utilizes biologically active radiolabeled compounds to image biochemical processes.
Yu‐Peng Zhou, Lauren L. Zhang, Yang Sun, Pedro Brugarolas   +3 more
doaj   +1 more source