Results 61 to 70 of about 55,685 (249)

The Rise of Synaptic Density PET Imaging

Molecules, 2020
Many neurological disorders are related to synaptic loss or pathologies. Before the boom of positrons emission tomography (PET) imaging of synapses, synaptic quantification could only be achieved in vitro on brain samples after autopsy or surgical ...
Guillaume Becker, Sylvestre Dammicco, Mohamed Ali Bahri, Eric Salmon   +3 more
doaj   +1 more source

PET amyloid-beta imaging in preclinical Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
Alzheimer's disease (AD) is the leading cause of dementia, accounting for 60-70% of all cases [Hebert et al., 2003, 1]. The need for effective therapies for AD is great. Current approaches, including cholinesterase inhibitors and N-methyl-d-aspartate (NMDA) receptor antagonists, are symptomatic treatments for AD but do not prevent disease progression ...
Vlassenko, Andrei G., Benzinger, Tammie L.S., Morris, John C.   +2 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Preclinical PET Study of Intravitreal Injections.

Investigative ophthalmology & visual science, 2017
This work aimed at describing the time course of vitreous clearance through the use of positron emission tomography (PET) as a noninvasive tool for pharmacokinetic studies of intravitreal injection.The pharmacokinetic profile of intravitreal injections of molecules labeled with 18Fluorine (18F) was evaluated in adult Sprague Dawley rats by using a ...
Fernández Ferreiro, Anxo, Luaces Rodríguez, Andrea, Aguiar Fernández, Pablo, Pardo Montero, Juan, González Barcia, Miguel, García Varela, Lara, Herranz, Michel, Silva Rodríguez, Jesús, Gil Martínez, María, Bermúdez Vázquez, María Elvira, Vieites Prado, Alba, Blanco Méndez, José, Lamas Díaz, María Jesús, Gómez-Ulla de Irazazábal, Francisco Javier, Ruibal Morell, Álvaro, Otero Espinar, Francisco Javier, González García, Francisco   +16 more
openaire   +2 more sources

Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease [PDF]

Neurology, 2013
OBJECTIVE: To examine the effect of education (a surrogate measure of cognitive reserve) on FDG-PET brain metabolism in elderly cognitively healthy (HC) subjects with preclinical Alzheimer disease (AD). METHODS: Fifty-two HC subjects (mean age 75 years) with FDG-PET and CSF measurement of Abeta1-42 were included from the prospective Alzheimer's Disease
Ewers, Michael, Insel, Philip S., Stern, Yaakov, Weiner, Michael W.   +3 more
openaire   +5 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [18F]Fluspidine—A New Tracer in Clinical Translation for Imaging of σ1 Receptors

Molecules, 2016
The enantiomers of [18F]fluspidine, recently developed for imaging of σ1 receptors, possess distinct pharmacokinetics facilitating their use in different clinical settings.
Mathias Kranz, Bernhard Sattler, Nathanael Wüst, Winnie Deuther-Conrad, Marianne Patt, Philipp M. Meyer, Steffen Fischer, Cornelius K. Donat, Bernhard Wünsch, Swen Hesse, Jörg Steinbach, Peter Brust, Osama Sabri   +12 more
doaj   +1 more source

VECTor: A Preclinical Imaging System for Simultaneous Submillimeter SPECT and PET [PDF]

Journal of Nuclear Medicine, 2012
Today, PET and SPECT tracers cannot be imaged simultaneously at high resolutions but require 2 separate imaging systems. This paper introduces a Versatile Emission Computed Tomography system (VECTor) for radionuclides that enables simultaneous submillimeter imaging of single-photon and positron-emitting radiolabeled molecules.γ-photons produced both by
Goorden, Marlies C., van der Have, Frans, Kreuger, Rob, Ramakers, Ruud M., Vastenhouw, Brendan, Burbach, J. Peter H., Booij, Jan, Molthoff, Carla F. M., Beekman, Freek J.   +8 more
openaire   +3 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

NEMA characterization of the SAFIR prototype PET insert

EJNMMI Physics, 2022
Background The SAFIR prototype insert is a preclinical Positron Emission Tomography (PET) scanner built to acquire dynamic images simultaneously with a 7 T Bruker Magnetic Resonance Imaging (MRI) scanner.
Parisa Khateri, Werner Lustermann, Christian Ritzer, Charalampos Tsoumpas, Günther Dissertori   +4 more
doaj   +1 more source