Results 41 to 50 of about 59,711 (283)
Performance evaluation of an Inveon PET preclinical scanner [PDF]
Physics in Medicine and Biology, 2009 We evaluated the performance of an Inveon preclinical PET scanner (Siemens Medical Solutions), the latest MicroPET system. Spatial resolution was measured with a glass capillary tube (0.26 mm inside diameter, 0.29 mm wall thickness) filled with (18)F solution.
Cristian C, Constantinescu +1 more
openaire +2 more sources
Frontiers in Neuroscience, 2017 Chronic inflammation is a common phenomenon present in the background of multiple neurodegenerative diseases, including Alzheimer's disease (AD). The arachidonic acid pathway overproduces proinflammatory eicosanoids during these states and glial cells in
Rea Pihlaja +4 more
doaj +1 more source
Development of Novel Fluorine-18 Labeled PET Radioligands for Monoamine Oxidase B (MAO-B) [PDF]
, 2013 Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selective and irreversible MAO-B inhibitors such as L-deprenyl and rasagiline are clinically used for the treatment of psychiatric and ...
Nag, Sangram
core +1 more source
Radiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages [PDF]
, 2022 Folate receptor β (FR-β), a marker expressed on macrophages, is a promising target for imaging of inflammation. Here, we report the radiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate (68Ga-FOL).
Palani S. +19 more
core +1 more source
EJNMMI Research, 2019 Background Positron emission tomography (PET) can be used for in vivo evaluation of the pathology associated with multiple sclerosis. We investigated the use of longitudinal PET imaging and the 18-kDa translocator protein (TSPO) binding radioligand [18F ...
S. K. Vainio +9 more
doaj +1 more source
Radiolabeled Antibodies for Immune Checkpoint PET in Preclinical Research [PDF]
, 2023 Antibodies that block immune checkpoints, also called immune checkpoint inhibitors (ICI), have demonstrated impressive anti-tumor efficacy. The success of ICIs results from a complex interplay between cancer cells and their immune microenvironment.
Boswinkel, M. +2 more
openaire +2 more sources
Molecular Imaging and the PD-L1 Pathway: From Bench to Clinic
Frontiers in Oncology, 2021 Programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors target the important molecular interplay between PD-1 and PD-L1, a key pathway contributing to immune evasion in the tumor microenvironment (TME).
David Leung +4 more
doaj +1 more source
Quality control of small animal PET scanner: The Brazilian Scenario
Brazilian Journal of Radiation Sciences, 2020 This work aims to evaluate the quality control program for small animal PET (positron emission tomography) scanners in Brazil. A questionnaire focused on type of small animal PET scanner and quality assurance program was prepared and sent to all ...
Rodrigo Modesto Gadelha Gontijo +3 more
doaj +1 more source
PET Radioligands for in Vivo Visualization of Neuroinflammation. [PDF]
, 2014 Neuroinflammation is a well-orchestrated, dynamic, multicellular process playing a major role in neurodegenerative disorders. The microglia which make up the innate immune system of the central nervous system are key cellular mediators of ...
Ory, Dieter +4 more
core +1 more source
EJNMMI Research, 2021 Introduction The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research.
Marion Chomet +11 more
doaj +1 more source