Results 31 to 40 of about 55,685 (249)

Radiolabeled Antibodies for Immune Checkpoint PET in Preclinical Research [PDF]

, 2023
Antibodies that block immune checkpoints, also called immune checkpoint inhibitors (ICI), have demonstrated impressive anti-tumor efficacy. The success of ICIs results from a complex interplay between cancer cells and their immune microenvironment.
Boswinkel, M., Franssen, G.M., Heskamp, S.   +2 more
openaire   +2 more sources

Quality control of small animal PET scanner: The Brazilian Scenario

Brazilian Journal of Radiation Sciences, 2020
This work aims to evaluate the quality control program for small animal PET (positron emission tomography) scanners in Brazil. A questionnaire focused on type of small animal PET scanner and quality assurance program was prepared and sent to all ...
Rodrigo Modesto Gadelha Gontijo, Andréa Vidal Ferreira, Juliana Batista Silva, Marcelo Mamede   +3 more
doaj   +1 more source

Protocols for Dual Tracer PET/SPECT Preclinical Imaging [PDF]

Frontiers in Physics, 2020
Multi-tracer PET/SPECT imaging enables different modality tracers to be present simultaneously, allowing multiple physiological processes to be imaged in the same subject, within a short time-frame. Fluorine-18 and technetium-99m, two commonly used PET and SPECT radionuclides, respectively, possess different emission profiles, offering the potential ...
Blower, Julia E, Bordoloi, Jayanta K, Rigby, Alex, Farleigh, Matthew, Kim, Jana, O'Brien, Hugh, Jackson, Jonathan, Poyiatzis, Constantinos, Bezer, James, Sunassee, Kavitha, Blower, Philip J, Livieratos, Lefteris   +11 more
openaire   +5 more sources

Performance of nanoScan PET/CT and PET/MR for quantitative imaging of 18F and 89Zr as compared with ex vivo biodistribution in tumor-bearing mice

EJNMMI Research, 2021
Introduction The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research.
Marion Chomet, Maxime Schreurs, Ricardo Vos, Mariska Verlaan, Esther J. Kooijman, Alex J. Poot, Ronald Boellaard, Albert D. Windhorst, Guus AMS van Dongen, Danielle J. Vugts, Marc C. Huisman, Wissam Beaino   +11 more
doaj   +1 more source

The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a 68Ga-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin

Molecules, 2014
The overexpression of gastrin-releasing peptide receptor (GRPR) in cancer can be used for peptide-receptor mediated radionuclide imaging and therapy.
Zohreh Varasteh, Ulrika Rosenström, Irina Velikyan, Bogdan Mitran, Mohamed Altai, Hadis Honarvar, Maria Rosestedt, Gunnar Lindeberg, Jens Sörensen, Mats Larhed, Vladimir Tolmachev, Anna Orlova   +11 more
doaj   +1 more source

Multiparametric Longitudinal Profiling of RCAS-tva-Induced PDGFB-Driven Experimental Glioma

Brain Sciences, 2022
Glioblastomas are incurable primary brain tumors harboring a heterogeneous landscape of genetic and metabolic alterations. Longitudinal imaging by MRI and [18F]FET-PET measurements enable us to visualize the features of evolving tumors in a dynamic ...
Hannes Becker, Salvador Castaneda-Vega, Kristin Patzwaldt, Justyna M. Przystal, Bianca Walter, Filippo C. Michelotti, Denis Canjuga, Marcos Tatagiba, Bernd Pichler, Susanne C. Beck, Eric C. Holland, Christian la Fougère, Ghazaleh Tabatabai   +12 more
doaj   +1 more source

Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [¹⁸F]AlF-Affibody Conjugates

Molecules, 2020
Site-selective bioconjugation of cysteine-containing peptides and proteins is currently achieved via a maleimide–thiol reaction (Michael addition).
Chiara Da Pieve, Ata Makarem, Stephen Turnock, Justyna Maczynska, Graham Smith, Gabriela Kramer-Marek   +5 more
doaj   +1 more source

PET Imaging in Preclinical Anti-Aβ Drug Development

Pharmaceutical Research, 2022
AbstractPositron emission tomography (PET), a medical imaging technique allowing for studies of the living human brain, has gained an important role in clinical trials of novel drugs against Alzheimer’s disease (AD). For example, PET data contributed to the conditional approval in 2021 ofaducanumab, an antibody directed towards amyloid-beta (Aβ ...
Stina Syvänen, Silvio R. Meier, Sahar Roshanbin, Mengfei Xiong, Rebecca Faresjö, Tobias Gustavsson, Gillian Bonvicini, Eva Schlein, Ximena Aguilar, Ulrika Julku, Jonas Eriksson, Dag Sehlin   +11 more
openaire   +3 more sources

Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA

EJNMMI Research
Background P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [11C]SMW139 is the most recently developed radiotracer to image P2X7 receptor.
Obada M. Alzghool, Richard Aarnio, Jatta S. Helin, Saara Wahlroos, Thomas Keller, Markus Matilainen, Junel Solis, Jonathan J. Danon, Michael Kassiou, Anniina Snellman, Olof Solin, Juha O. Rinne, Merja Haaparanta-Solin   +12 more
doaj   +1 more source

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source