Results 11 to 20 of about 59,711 (283)
ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience [PDF]
Biomolecules, 2023 Immuno-positron emission tomography (immunoPET) is a non-invasive in vivo imaging method based on tracking and quantifying radiolabeled monoclonal antibodies (mAbs) and other related molecules, such as antibody fragments, nanobodies, or affibodies ...
Ángel García de Lucas +2 more
doaj +2 more sources
PET Imaging in Preclinical Anti-Aβ Drug Development
Pharmaceutical Research, 2022 AbstractPositron emission tomography (PET), a medical imaging technique allowing for studies of the living human brain, has gained an important role in clinical trials of novel drugs against Alzheimer’s disease (AD). For example, PET data contributed to the conditional approval in 2021 ofaducanumab, an antibody directed towards amyloid-beta (Aβ ...
Stina Syvänen +11 more
openaire +4 more sources
[<sup>11</sup>C]Fentanyl: radiosynthesis and preclinical pet imaging for its pharmacokinetics. [PDF]
EJNMMI Radiopharm ChemAbstract Background Fentanyl is a potent synthetic opioid widely used for pain management and anesthesia, but the high prevalence of its misuse and its key contribution to overdose fatalities in the United States have made it a major drug of concern.
Kim W +11 more
europepmc +4 more sources
A preclinical PET detector constructed with a monolithic scintillator ring. [PDF]
Phys Med Biol, 2019 Abstract This paper presents a unique preclinical positron emission tomography (PET) detector constructed with a monolithic scintillator ring (MSR) and two rings of silicon photomultipliers (SiPM). The inner diameter, outer diameter and length of the MSR were 48.5 mm, 58.5 mm, and 25.1 mm, respectively.
Xu J +9 more
europepmc +4 more sources
Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease [PDF]
Neurology, 2013 OBJECTIVE: To examine the effect of education (a surrogate measure of cognitive reserve) on FDG-PET brain metabolism in elderly cognitively healthy (HC) subjects with preclinical Alzheimer disease (AD). METHODS: Fifty-two HC subjects (mean age 75 years) with FDG-PET and CSF measurement of Abeta1-42 were included from the prospective Alzheimer's Disease
Ewers, Michael +3 more
openaire +7 more sources
Quantitative preclinical PET imaging: opportunities and challenges
Frontiers in Physics, 2014 PET imaging of metabolism involves many choices, from hardware settings, software options to animal handling considerations. How to decide what settings or conditions to use is not straightforward, as the experimental design is dependent on the ...
Claudia Kuntner +2 more
exaly +3 more sources
A Digital Preclinical PET/MRI Insert and Initial Results [PDF]
IEEE Transactions on Medical Imaging, 2015 Combining Positron Emission Tomography (PET) with Magnetic Resonance Imaging (MRI) results in a promising hybrid molecular imaging modality as it unifies the high sensitivity of PET for molecular and cellular processes with the functional and anatomical information from MRI.
Pierre Gebhardt +2 more
exaly +6 more sources
SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRI [PDF]
Sensors, 2021 Pascal Bebie +2 more
exaly +2 more sources
Clinical applications of PET/MRI: current status and future perspectives [PDF]
Diagnostic and Interventional Radiology, 2014 Fully integrated positron emission tomography (PET)/magnetic resonance imaging (MRI) scanners have been available for a few years. Since then, the number of scanner installations and published studies have been growing.
Felix Nensa +3 more
doaj +2 more sources
EJNMMI Physics, 2016 Background Both enantiomers of [18F]flubatine are new radioligands for neuroimaging of α4β2 nicotinic acetylcholine receptors with positron emission tomography (PET) exhibiting promising pharmacokinetics which makes them attractive for different clinical
Mathias Kranz +2 more
exaly +3 more sources