Preclinical PET Neuroimaging of [C]Bexarotene [PDF]
Molecular Imaging, 2016 Activation of retinoid X receptors (RXRs) has been proposed as a therapeutic mechanism for the treatment of neurodegeneration, including Alzheimer's and Parkinson's diseases. We previously reported radiolabeling of a Food and Drug Administration-approved
Benjamin H. Rotstein PhD +9 more
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Compensating Positron Range Effects of Ga-68 in Preclinical PET Imaging by Using Convolutional Neural Network: A Monte Carlo Simulation Study [PDF]
Diagnostics, 2021 This study aimed to investigate the feasibility of positron range correction based on three different convolutional neural network (CNN) models in preclinical PET imaging of Ga-68.
Ching-Ching Yang
exaly +4 more sources
Performance evaluation of a PET insert for preclinical MRI in stand-alone PET and simultaneous PET–MRI modes [PDF]
EJNMMI Physics, 2021 Background This study aimed to evaluate the performance of a preclinical PET insert in three configurations: as a stand-alone unit outside the MRI bore, inside the bore of a cryogen-free 3T MRI and, finally, while performing simultaneous PET/MRI studies.
Steven Meikle +2 more
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Translation of Preclinical PET Imaging Findings: Challenges and Motion Correction to Overcome the Confounding Effect of Anesthetics [PDF]
Frontiers in Medicine, 2021 Preclinical brain positron emission tomography (PET) in animals is performed using anesthesia to avoid movement during the PET scan. In contrast, brain PET scans in humans are typically performed in the awake subject.
Alan Miranda +5 more
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Tomography, 2023 We have integrated a compact and lightweight PET with an existing CT image-guided small animal irradiator to enable practical onboard PET/CT image-guided preclinical radiation therapy (RT) research.
Yiping Shao, Dongxu Yang, Xiankai Sun
exaly +3 more sources
Preclinical PET and SPECT Imaging in Small Animals: Technologies, Challenges and Translational Impact [PDF]
CellsMolecular imaging in preclinical research using PET and SPECT has become a key component of contemporary biomedicine, enabling noninvasive, quantitative, and longitudinal assessment of biological processes in vivo. Rapid technological progress, including
Magdalena Bruzgo-Grzybko +5 more
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Preclinical PET and MR Evaluation of 89Zr- and 68Ga-Labeled Nanodiamonds in Mice over Different Time Scales [PDF]
Nanomaterials, 2022 Nanodiamonds (NDs) have high potential as a drug carrier and in combination with nitrogen vacancies (NV centers) for highly sensitive MR-imaging after hyperpolarization. However, little remains known about their physiological properties in vivo.
Gordon Winter +14 more
doaj +2 more sources
Quantitative preclinical PET imaging: opportunities and challenges
Frontiers in Physics, 2014 PET imaging of metabolism involves many choices, from hardware settings, software options to animal handling considerations. How to decide what settings or conditions to use is not straightforward, as the experimental design is dependent on the ...
Claudia Kuntner +2 more
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SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRI [PDF]
Sensors, 2021 Christian Edwin Ritzer +2 more
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ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience
Biomolecules, 2023 Immuno-positron emission tomography (immunoPET) is a non-invasive in vivo imaging method based on tracking and quantifying radiolabeled monoclonal antibodies (mAbs) and other related molecules, such as antibody fragments, nanobodies, or affibodies ...
Ángel García de Lucas +2 more
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