Translation of Preclinical PET Imaging Findings: Challenges and Motion Correction to Overcome the Confounding Effect of Anesthetics [PDF]
Frontiers in Medicine, 2021 Preclinical brain positron emission tomography (PET) in animals is performed using anesthesia to avoid movement during the PET scan. In contrast, brain PET scans in humans are typically performed in the awake subject.
Alan Miranda +2 more
exaly +4 more sources
Preclinical PET Neuroimaging of [C]Bexarotene [PDF]
Molecular Imaging, 2016 Activation of retinoid X receptors (RXRs) has been proposed as a therapeutic mechanism for the treatment of neurodegeneration, including Alzheimer's and Parkinson's diseases. We previously reported radiolabeling of a Food and Drug Administration-approved
Benjamin H. Rotstein PhD +9 more
doaj +5 more sources
Compensating Positron Range Effects of Ga-68 in Preclinical PET Imaging by Using Convolutional Neural Network: A Monte Carlo Simulation Study [PDF]
Diagnostics, 2021 This study aimed to investigate the feasibility of positron range correction based on three different convolutional neural network (CNN) models in preclinical PET imaging of Ga-68.
Ching-Ching Yang
exaly +4 more sources
Advances in Preclinical PET. [PDF]
Semin Nucl Med, 2022 The classical intent of PET imaging is to obtain the most accurate estimate of the amount of positron-emitting radiotracer in the smallest possible volume element located anywhere in the imaging subject at any time using the least amount of radioactivity.
Adler SS, Seidel J, Choyke PL.
europepmc +3 more sources
Advances in Preclinical PET Instrumentation [PDF]
PET Clinics, 2020 In the light of ever-increasing demands for PET scanner with better resolvability, higher sensitivity and wide accessibility for noninvasive screening of small structures and physiological processes in laboratory rodents, several dedicated PET scanners were developed and evaluated.
Habib Zaidi, Mohammad Reza Ay
exaly +4 more sources
Preclinical PET and SPECT Imaging in Small Animals: Technologies, Challenges and Translational Impact [PDF]
CellsMolecular imaging in preclinical research using PET and SPECT has become a key component of contemporary biomedicine, enabling noninvasive, quantitative, and longitudinal assessment of biological processes in vivo. Rapid technological progress, including
Magdalena Bruzgo-Grzybko +5 more
doaj +2 more sources
Preclinical PET and MR Evaluation of 89Zr- and 68Ga-Labeled Nanodiamonds in Mice over Different Time Scales [PDF]
Nanomaterials, 2022 Nanodiamonds (NDs) have high potential as a drug carrier and in combination with nitrogen vacancies (NV centers) for highly sensitive MR-imaging after hyperpolarization. However, little remains known about their physiological properties in vivo.
Gordon Winter +14 more
doaj +2 more sources
Tomography, 2023 We have integrated a compact and lightweight PET with an existing CT image-guided small animal irradiator to enable practical onboard PET/CT image-guided preclinical radiation therapy (RT) research.
Xinyi Cheng +2 more
exaly +3 more sources
Performance evaluation of a PET insert for preclinical MRI in stand-alone PET and simultaneous PET–MRI modes [PDF]
EJNMMI Physics, 2021 Background This study aimed to evaluate the performance of a preclinical PET insert in three configurations: as a stand-alone unit outside the MRI bore, inside the bore of a cryogen-free 3T MRI and, finally, while performing simultaneous PET/MRI studies.
Gaelle Emvalomenos +10 more
doaj +3 more sources
Spatial resolution of a preclinical PET tomograph
Brazilian Journal of Radiation Sciences, 2021 Positron emission tomography (PET) is an important molecular image modality and its application on preclinical research has increased during last decades.
Guilherme Cavalcante de Albuquerque Souza +4 more
doaj +3 more sources