Results 21 to 30 of about 55,685 (249)

PET Imaging in Animal Models of Alzheimer’s Disease

Frontiers in Neuroscience, 2022
The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for in vivo detection of these hallmarks of Alzheimer’s disease (AD) antemortem.
Baosheng Chen, Bernadette Marquez-Nostra, Erika Belitzky, Takuya Toyonaga, Jie Tong, Yiyun Huang, Zhengxin Cai   +6 more
doaj   +1 more source

Preclinical Evaluation of Novel PET Probes for Dementia

Seminars in Nuclear Medicine, 2023
The development of novel PET imaging agents that selectively bind specific dementia-related targets can contribute significantly to accurate, differential and early diagnosis of dementia causing diseases and support the development of therapeutic agents.
Romy Cools, Kobe Kerkhofs, Renan C.F. Leitao, Guy Bormans   +3 more
openaire   +3 more sources

PET performance evaluation of a preclinical digital PET/MRI insert [PDF]

EJNMMI Physics, 2014
In recent years, several groups have presented combined PET/MRI devices for clinical and preclinical research. Using new technologies like SiPMs, the performance of the systems improved over the years allowing a detailed exploration of the relatively new field of hybrid imaging modality.
Schug, David, Lerche, Christoph, Dueppenbecker, Peter, Gebhardt, Pierre, Goldschmidt, Benjamin, Salomon, Andre, Wehner, Jakob, Weissler, Bjoern, Kiessling, Fabian, Schulz, Volkmar   +9 more
openaire   +2 more sources

PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging

Frontiers in Neuroscience, 2022
The development of novel PET imaging agents for synaptic vesicle glycoprotein 2A (SV2A) allowed for the in vivo detection of synaptic density changes, which are correlated with the progression and severity of a variety of neuropsychiatric diseases. While
Takuya Toyonaga, Arman Fesharaki-Zadeh, Arman Fesharaki-Zadeh, Stephen M. Strittmatter, Stephen M. Strittmatter, Richard E. Carson, Zhengxin Cai   +6 more
doaj   +1 more source

[¹¹C]Fentanyl: radiosynthesis and preclinical pet imaging for its pharmacokinetics. [PDF]

EJNMMI Radiopharm Chem
Abstract Background Fentanyl is a potent synthetic opioid widely used for pain management and anesthesia, but the high prevalence of its misuse and its key contribution to overdose fatalities in the United States have made it a major drug of concern.
Kim W, Wozniak AK, Burkard NJ, Freaney ML, Costamagna-Soto A, O'Conor KA, Bakhoda A, Eisenberg SM, Zhao W, Liow JS, Volkow ND, Kim SW.   +11 more
europepmc   +4 more sources

The Anti-Inflammatory Effects of Lipoxygenase and Cyclo-Oxygenase Inhibitors in Inflammation-Induced Human Fetal Glia Cells and the Aβ Degradation Capacity of Human Fetal Astrocytes in an Ex vivo Assay

Frontiers in Neuroscience, 2017
Chronic inflammation is a common phenomenon present in the background of multiple neurodegenerative diseases, including Alzheimer's disease (AD). The arachidonic acid pathway overproduces proinflammatory eicosanoids during these states and glial cells in
Rea Pihlaja, Rea Pihlaja, Merja Haaparanta-Solin, Merja Haaparanta-Solin, Juha O. Rinne   +4 more
doaj   +1 more source

Performance evaluation of an Inveon PET preclinical scanner [PDF]

Physics in Medicine and Biology, 2009
We evaluated the performance of an Inveon preclinical PET scanner (Siemens Medical Solutions), the latest MicroPET system. Spatial resolution was measured with a glass capillary tube (0.26 mm inside diameter, 0.29 mm wall thickness) filled with (18)F solution.
Cristian C, Constantinescu, Jogeshwar, Mukherjee   +1 more
openaire   +2 more sources

Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation

EJNMMI Research, 2019
Background Positron emission tomography (PET) can be used for in vivo evaluation of the pathology associated with multiple sclerosis. We investigated the use of longitudinal PET imaging and the 18-kDa translocator protein (TSPO) binding radioligand [18F ...
S. K. Vainio, A. M. Dickens, J. Tuisku, O. Eskola, O. Solin, E. Löyttyniemi, D. C. Anthony, J. O. Rinne, L. Airas, M. Haaparanta-Solin   +9 more
doaj   +1 more source

A preclinical PET detector constructed with a monolithic scintillator ring. [PDF]

Phys Med Biol, 2019
Abstract This paper presents a unique preclinical positron emission tomography (PET) detector constructed with a monolithic scintillator ring (MSR) and two rings of silicon photomultipliers (SiPM). The inner diameter, outer diameter and length of the MSR were 48.5 mm, 58.5 mm, and 25.1 mm, respectively.
Xu J, Xie S, Zhang X, Tao W, Yang J, Zhao Z, Weng F, Huang Q, Yi F, Peng Q.   +9 more
europepmc   +4 more sources

Molecular Imaging and the PD-L1 Pathway: From Bench to Clinic

Frontiers in Oncology, 2021
Programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors target the important molecular interplay between PD-1 and PD-L1, a key pathway contributing to immune evasion in the tumor microenvironment (TME).
David Leung, Samuel Bonacorsi, Ralph Adam Smith, Wolfgang Weber, Wendy Hayes   +4 more
doaj   +1 more source