Results 171 to 180 of about 518,230 (247)

Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets. [PDF]

EJNMMI Res
Hernández-Martín N, Pozo-Cabanell I, Fernández de la Rosa R, García-García L, Gómez-Oliver F, Pozo MÁ, Brackhan M, Bascuñana P.   +7 more
europepmc   +1 more source

Standardization of Preclinical PET/CT Imaging to Improve Quantitative Accuracy, Precision, and Reproducibility: A Multicenter Study. [PDF]

J Nucl Med, 2020
McDougald W, Vanhove C, Lehnert A, Lewellen B, Wright J, Mingarelli M, Corral CA, Schneider JE, Plein S, Newby DE, Welch A, Miyaoka R, Vandenberghe S, Tavares AAS.   +13 more
europepmc   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

First performance evaluation of easyPET.3D, a high-resolution and cost-effective benchtop preclinical PET scanner. [PDF]

EJNMMI Phys
Ribeiro FM, Encarnação PMCC, Silva ALM, Correia PMM, Pinto AX, Oliveira RG, Sereno J, Pais ML, Abrunhosa A, Castro IF, Santos AC, Veloso JFCA.   +11 more
europepmc   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

[⁶⁸Ga]Ga-DOTAGA-Glu(FAPi)₂ Shows Enhanced Tumor Uptake and Theranostic Potential in Preclinical PET Imaging. [PDF]

Diagnostics (Basel)
Mortensen JVK, Mattiussi S, Hvass L, Lund EG, Shalgunov V, Roesch F, Battisti UM, Herth MM, Kjaer A.   +8 more
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Economic Evaluation of Positron Emission Tomography (PET) in Non Small Cell Lung Cancer (NSCLC), CHERE Working Paper 2007/6 [PDF]

Background: There are several perceived benefits from introducing positron emission tomography (PET) scanning into the staging of non small lung cancer (NSCLC).
Stephen Goodall, Alex Bird, Richard Norman   +2 more
core  

Validation of the design of a high-sensitivity and high-resolution PET system for a preclinical PET/EPR hybrid scanner. [PDF]

Nucl Instrum Methods Phys Res A
Kim H, Hua Y, Chen CT, Epel B, Sundramoorthy S, Halpern H, Kao CM.   +6 more
europepmc   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source