Results 151 to 160 of about 55,685 (249)

Preclinical PET imaging of the developing fetus during pregnancy: Current state and future potential. [PDF]

J Cereb Blood Flow Metab
Pearson TD, Bricault S, Lin YS, Barusso KE, Bodangi S, Wey HY.   +5 more
europepmc   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets. [PDF]

EJNMMI Res
Hernández-Martín N, Pozo-Cabanell I, Fernández de la Rosa R, García-García L, Gómez-Oliver F, Pozo MÁ, Brackhan M, Bascuñana P.   +7 more
europepmc   +1 more source

Standardization of Preclinical PET/CT Imaging to Improve Quantitative Accuracy, Precision, and Reproducibility: A Multicenter Study. [PDF]

J Nucl Med, 2020
McDougald W, Vanhove C, Lehnert A, Lewellen B, Wright J, Mingarelli M, Corral CA, Schneider JE, Plein S, Newby DE, Welch A, Miyaoka R, Vandenberghe S, Tavares AAS.   +13 more
europepmc   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

First performance evaluation of easyPET.3D, a high-resolution and cost-effective benchtop preclinical PET scanner. [PDF]

EJNMMI Phys
Ribeiro FM, Encarnação PMCC, Silva ALM, Correia PMM, Pinto AX, Oliveira RG, Sereno J, Pais ML, Abrunhosa A, Castro IF, Santos AC, Veloso JFCA.   +11 more
europepmc   +1 more source

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

[⁶⁸Ga]Ga-DOTAGA-Glu(FAPi)₂ Shows Enhanced Tumor Uptake and Theranostic Potential in Preclinical PET Imaging. [PDF]

Diagnostics (Basel)
Mortensen JVK, Mattiussi S, Hvass L, Lund EG, Shalgunov V, Roesch F, Battisti UM, Herth MM, Kjaer A.   +8 more
europepmc   +1 more source

Nano‐Confined Radical Anion as An NIR‐II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination

Advanced Science, EarlyView.
A nano‐confined radical anion acts as a photothermal immunogenic amplifier. Kinetically stabilized nanoparticles couple high near‐infrared‐II (NIR‐II) photothermal efficacy with glutathione (GSH) depletion to boost reactive oxygen species (ROS) and immunogenic cell death (ICD).
Mengxin Mu, Mengyu Guo, Jun Guan, Xiaofeng He, Mingdi Hu, Fene Gao, Klaus Müllen, Chendong Ji, Chunying Chen, Meizhen Yin   +9 more
wiley   +1 more source

Validation of the design of a high-sensitivity and high-resolution PET system for a preclinical PET/EPR hybrid scanner. [PDF]

Nucl Instrum Methods Phys Res A
Kim H, Hua Y, Chen CT, Epel B, Sundramoorthy S, Halpern H, Kao CM.   +6 more
europepmc   +1 more source