Results 141 to 150 of about 59,711 (283)
Advanced Science, EarlyView.This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma +10 more
wiley +1 more source
6th Internatinal TPCF Preclinical Imaging Symposium
As we step into 2023, the landscape of translational medicine continues to evolve, revealing the profound importance of preclinical imaging in bridging the gap between laboratory discoveries and clinical applications.
6 th Internatinal TPCF Preclinical Imaging
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Development of the G3 Designed ankyrin repeat protein (DARPin) for HER2 imaging
, 2015 Background: Human epidermal growth factor receptor-2 (HER2) expression predicts response to anti-HER2 therapy in breast and gastric cancer. HER2 status is assessed by tumour biopsy but this may not be representative of the larger tumour mass or other ...
Goldstein, RM
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Radiofluorination of oxazole-carboxamides for preclinical PET neuroimaging of GSK-3. [PDF]
J Fluor Chem, 2021 Varlow C +4 more
europepmc +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
7th International Conference on Preclinical Imaging Applications
As we embrace 2024, the field of translational medicine stands at an exciting crossroads where innovation, collaboration, and cutting-edge technology converge. Among the most powerful tools driving this transformation is preclinical imaging, a discipline
7 th International TPCF Preclinical Imaging
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Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, EarlyView.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
, 2021 This thesis investigates quantitative methods for the characterisation of dopamine (DA) release in preclinical PET. The goal was to develop methodologies that improve quantification of the PET signal and test to what extent these techniques can reliably ...
EMVALOMENOS, Gaelle
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Optimized Methodology for Reference Region and Image-Derived Input Function Kinetic Modeling in Preclinical PET. [PDF]
IEEE Trans Radiat Plasma Med Sci, 2022 Bini J +4 more
europepmc +1 more source