Results 141 to 150 of about 55,685 (249)

Preclinical PET Imaging of NTSR-1-Positive Tumors with ⁶⁴Cu- and ⁶⁸Ga-DOTA-Neurotensin Analogs and Therapy with an ²²⁵Ac-DOTA-Neurotensin Analog. [PDF]

Cancer Biother Radiopharm, 2021
Li D, Minnix M, Allen R, Bading J, Chea J, Wong P, Bowles N, Poku E, Shively JE.   +8 more
europepmc   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Correction: Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA

EJNMMI Research
Obada M. Alzghool, Richard Aarnio, Jatta S. Helin, Saara Wahlroos, Thomas Keller, Markus Matilainen, Junel Solis, Jonathan J. Danon, Michael Kassiou, Anniina Snellman, Olof Solin, Juha O. Rinne, Merja Haaparanta‑Solin   +12 more
doaj   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Digital PET/MRI for preclinical applications

, 2016
Combining different medical imaging modalities into a single device is a promising way to attain comprehensive and complementary information. Hybrid imaging modalities thus enable new research methods, improve diagnostic accuracy, and improve clinical workflow.
openaire   +1 more source

Image quality analysis of ⁴⁴Sc on two preclinical PET scanners: a comparison to ⁶⁸Ga. [PDF]

EJNMMI Phys, 2020
Rosar F, Buchholz HG, Michels S, Hoffmann MA, Piel M, Waldmann CM, Rösch F, Reuss S, Schreckenberger M.   +8 more
europepmc   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Performance evaluation of the ACTIVE 7 MAX benchtop preclinical PET scanner in accordance with the NEMA NU 4-2008 standard. [PDF]

EJNMMI Phys
Wang H, Wang K, Yuan Z, Li C, Liao R, Hou Y, Hua J, Tang Y, Ruan Q, Han D, Jiang J.   +10 more
europepmc   +1 more source

A preclinical PET dual-tracer imaging protocol for ER and HER2 phenotyping in breast cancer xenografts. [PDF]

EJNMMI Res, 2020
Paquette M, Phoenix S, Lawson C, Guérin B, Lecomte R, Tai LH, Turcotte ÉE, Leyton JV.   +7 more
europepmc   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source