Results 161 to 170 of about 518,230 (247)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

[¹¹C]Fentanyl: radiosynthesis and preclinical pet imaging for its pharmacokinetics. [PDF]

EJNMMI Radiopharm Chem
Kim W, Wozniak AK, Burkard NJ, Freaney ML, Costamagna-Soto A, O'Conor KA, Bakhoda A, Eisenberg SM, Zhao W, Liow JS, Volkow ND, Kim SW.   +11 more
europepmc   +1 more source

Image quality analysis of ⁴⁴Sc on two preclinical PET scanners: a comparison to ⁶⁸Ga. [PDF]

EJNMMI Phys, 2020
Rosar F, Buchholz HG, Michels S, Hoffmann MA, Piel M, Waldmann CM, Rösch F, Reuss S, Schreckenberger M.   +8 more
europepmc   +1 more source

Preclinical PET Imaging of NTSR-1-Positive Tumors with ⁶⁴Cu- and ⁶⁸Ga-DOTA-Neurotensin Analogs and Therapy with an ²²⁵Ac-DOTA-Neurotensin Analog. [PDF]

Cancer Biother Radiopharm, 2021
Li D, Minnix M, Allen R, Bading J, Chea J, Wong P, Bowles N, Poku E, Shively JE.   +8 more
europepmc   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Performance evaluation of the ACTIVE 7 MAX benchtop preclinical PET scanner in accordance with the NEMA NU 4-2008 standard. [PDF]

EJNMMI Phys
Wang H, Wang K, Yuan Z, Li C, Liao R, Hou Y, Hua J, Tang Y, Ruan Q, Han D, Jiang J.   +10 more
europepmc   +1 more source

A preclinical PET dual-tracer imaging protocol for ER and HER2 phenotyping in breast cancer xenografts. [PDF]

EJNMMI Res, 2020
Paquette M, Phoenix S, Lawson C, Guérin B, Lecomte R, Tai LH, Turcotte ÉE, Leyton JV.   +7 more
europepmc   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Preclinical PET imaging of the developing fetus during pregnancy: Current state and future potential. [PDF]

J Cereb Blood Flow Metab
Pearson TD, Bricault S, Lin YS, Barusso KE, Bodangi S, Wey HY.   +5 more
europepmc   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source