Results 91 to 100 of about 31,350 (256)

Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome

Neurobiology of Disease, 2011
Pregabalin, a Ca2+ channel α2δ-subunit antagonist with analgesic and antiepileptic activity, reduced neuronal loss and improved functional outcome in a mouse model of focal ischemic stroke.
Jeong Seon Yoon, Jong-Hwan Lee, Tae Gen Son, Mohamed R. Mughal, Nigel H. Greig, Mark P. Mattson   +5 more
doaj   +1 more source

Randomised clinical trial: pregabalin vs placebo for irritable bowel syndrome

Alimentary Pharmacology and Therapeutics, 2019
Pregabalin is a calcium channel α2δ ligand that modifies visceral hypersensitivity in IBS patients. Clinical data for pregabalin in IBS are lacking.
Yuri A Saito, Ann E. Almazar, Katherine E. Tilkes, R. Choung, M. V. Van Norstrand, C. Schleck, A. Zinsmeister, N. Talley   +7 more
semanticscholar   +1 more source

Lumbosacral Plexopathy: A Single‐Center Review of Etiology, Clinical Presentation, Electrodiagnostic Findings, and Long‐Term Outcomes

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Lumbosacral plexopathy (LSP) results from a spectrum of etiologies and can cause substantial functional impairment. Limited data exist on the relative distribution of etiologies and outcomes across broad tertiary‐care cohorts spanning multiple causes of LSP.
Bradley Ong, Jad El Ahdab, Nicolas Thompson, Yuebing Li, Nirmal Andrapalliyal   +4 more
wiley   +1 more source

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, EarlyView.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

Pregabalin does not decrease acute pain or postoperative nausea and vomiting after hysterectomy: a meta-analysis

Journal of International Medical Research, 2020
Objective Hysterectomy is associated with severe postoperative pain. The relative efficacy of pregabalin compared with other treatments for post-hysterectomy pain is unclear.
Jie Ni, Juan Jiang, Shiqin Mao, Rui-fang Sun   +3 more
doaj   +1 more source

Shared struggles: Parallels in caregiver burden between canine and paediatric epilepsy

Veterinary Record, EarlyView.
Abstract Background Disease‐specific aspects of pet owners’ caregiver burden could be missed by generic burden measures. This study aimed to assess whether a framework developed to describe caregiver burden in parents of children with epilepsy was applicable to caregivers of dogs with epilepsy.
Zoe Belshaw, Rowena M. A. Packer
wiley   +1 more source

Comparative Efficacy of Elinzanetant Versus Other Non‐Hormonal Pharmaceutical Therapies for the Treatment of Moderate‐to‐Severe Vasomotor Symptoms Associated With Menopause: A Network Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Elinzanetant, a novel, dual neurokinin‐targeted therapy, has been approved in various geographies for the treatment of moderate‐to‐severe vasomotor symptoms (VMS) associated with menopause. Objective To compare the efficacy of elinzanetant with non‐hormonal pharmaceutical treatments (nHT) in alleviating VMS.
Piotr Wojciechowski, Klaudia Kolonko, Andromachi Giannopoulou, Beata Smela, Elżbieta Olewinska, Kristina Rosa Bolling, Jenifer Sassarini, Lee P. Shulman, Vikram Talaulikar   +8 more
wiley   +1 more source

Efficacy of perioperative pregabalin in acute and chronic post-operative pain after off-pump coronary artery bypass surgery: A randomized, double-blind placebo controlled trial

Annals of Cardiac Anaesthesia, 2013
Aims and Objectives: We evaluated the efficacy of perioperative pregabalin on acute and chronic post-operative pain after off-pump coronary artery bypass (OPCAB) surgery.
Shreedhar S Joshi, A M Jagadeesh
doaj   +1 more source

Benzodiazepine Use and Mortality Risk: A Nationwide Cohort Study on New Benzodiazepine Users With a 5‐Year Follow‐Up

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction We aimed to investigate the risks of all‐cause and cause‐specific mortality associated with dose‐dependent benzodiazepine and Z‐drug (BZDR) use in the Finnish population initiating new BZDR use with five‐year follow‐up. Methods Study subjects were included if BZDR use had started in 2006 with no BZDR dispensing during the ...
Hanna Särkilä, Heidi Taipale, Antti Tanskanen, Tero Taiminen, Reijo Sund, Terhi Kurko, Jarmo Hietala, Solja Niemelä   +7 more
wiley   +1 more source

Extended‐release buprenorphine in adults with opioid use disorder involving poppy seed tea: An 18‐month retrospective case series

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Poppy seed tea (PST) contains unpredictable opioid concentrations, destabilising tolerance and increasing overdose risk. Extended‐release buprenorphine (BUP‐XR) provides sustained coverage without daily dosing. Methods Eighteen‐month follow‐up of adults (N = 3) with opioid use disorder (OUD) involving PST in Australia.
John McMaster, Saumiya Seshakumaran, Hesitha Abeysundera, Isha Tipirneni, Rita Hormiz   +4 more
wiley   +1 more source