NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials [PDF]
, 2013 BACKGROUND HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection.
Brew, Bruce J +9 more
core +1 more source
The Comparison of Gabapentin and Amitriptilin Effectivity as Pain Therapy in Herniated Nucleus Pulposus [PDF]
, 2015 Herniated nucleus pulposus (HNP) is one of peripheral neuropathic pain. Although concensus guidelines for the treatment of neuropathic pain are based on the results of the RCT studies, there are still gaps in the literatures.
Cahyaningsih, I. (Indriastuti) +2 more
core
Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: The trigeminal neuralgia experience [PDF]
, 2018 Background: This study aimed to describe recruitment challenges encountered during a phase IIa study of vixotrigine, a state and use-dependent Nav1.7 channel blocker, in individuals with trigeminal neuralgia.
Bendtsen, Lars +10 more
core +4 more sources
Things We Do for No Reason™: Prescribing gabapentinoids for pain
Journal of Hospital Medicine, EarlyView.Abstract Gabapentin and pregabalin are among the most frequently prescribed medications in the United States, with gabapentin in the top 10 and pregabalin in the top 100. Despite FDA approval for only select neuropathic conditions, most use is for off‐label pain indications.
Niti G. Patel +4 more
wiley +1 more source
Managing the symptoms of neuropathic pain: An exploration of patients' experiences [PDF]
, 2007 The debilitating effects of chronic neuropathic pain on everyday life are considerable but little is known about how individual sufferers manage these effects.
Bennett +25 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT This study aimed to compare efficacy and safety of ultrasound‐guided erector spinae plane block (ESPB) using liposomal (LB) versus conventional bupivacaine (CB), each plus standardized gabapentin, in patients with postherpetic neuralgia (PHN). A total of 116 PHN patients were randomized to ESPB‐LB or ESPB‐CB; both groups received standardized ...
Xia‐Jing Xu +3 more
wiley +1 more source
Comparison of gabapentin and ketotifen in treatment of uremic pruritus in hemodialysis patients [PDF]
, 2016 Objectives: Uremic pruritus is a common problem in hemodialysis patients. Several treatments have been used for decreasing itching in these patients. Gabapentin and ketotifen are two drugs used for treating uremic patients.The aim of this study was to ...
Amirkhanlou, S. +4 more
core +1 more source
Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome
Neurobiology of Disease, 2011 Pregabalin, a Ca2+ channel α2δ-subunit antagonist with analgesic and antiepileptic activity, reduced neuronal loss and improved functional outcome in a mouse model of focal ischemic stroke.
Jeong Seon Yoon +5 more
doaj +1 more source
Pregabalin induced visual hallucinations – a rare adverse reaction
BMC Pharmacology and Toxicology, 2020 Background Pregabalin is an anticonvulsive, analgesic and anxiolytic medication. The typical side effects include dizziness, somnolence and weight gain. Few studies or case reports have demonstrated psychiatric side effects resulting from its use.
Georgios Mousailidis +4 more
doaj +1 more source
Designing the ideal perioperative pain management plan starts with multimodal analgesia. [PDF]
, 2018 Multimodal analgesia is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while reducing individual class-related side effects ...
Mariano, Edward R., Schwenk, Eric S.
core +1 more source