Results 101 to 110 of about 26,979 (243)

Pregabalin acts on Na+–Ca2+ exchanger, which promotes Ca2+ extrusion from human Merkel cell line

PAIN Reports
. Introduction:. Pregabalin, a first-line treatment for neuropathic pain, binds to the voltage-gated calcium channel auxiliary subunit alpha2delta-1, reducing neurotransmitter release.
Rumi Kaneko, Takehito Ouchi, Maki Kimura, Hidetaka Kuroda, Tatsuya Ichinohe, Yoshiyuki Shibukawa   +5 more
doaj   +1 more source

Improvement in pain severity category in clinical trials of pregabalin

, 2016
Bruce Parsons,1 Charles E Argoff,2 Andrew Clair,1 Birol Emir1 1Pfizer, New York, NY, USA; 2Albany Medical Center, Albany, NY, USA Background: Pregabalin is approved by the US Food and Drug Administration for the treatment of fibromyalgia (FM ...
Argoff CE, Clair A, Parsons B, Emir B
core  

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Evaluation of the effect of pregabalin on simulated driving ability using a driving simulator in healthy male volunteers

International Journal of General Medicine, 2014
Tomoaki Tujii, Win Thiri Kyaw, Hirotaka Iwaki, Noriko Nishikawa, Masahiro Nagai, Madoka Kubo, Masahiro Nomoto Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Tohon Ehime, Japan Abstract: Pregabalin, a ...
Tujii T, Kyaw WT, Iwaki H, Nishikawa N, Nagai M, Kubo M, Nomoto M   +6 more
doaj  

A case report of pregabalin misuse leading to drug dependence

Frontiers in Psychiatry
Pregabalin misuse and dependence have become emerging concerns in recent years, particularly in regions where traditional drug-related crimes have been curbed, prompting users to seek alternative substances.
Yaan Luo, Yaan Luo, Xiafeng Zhou, Xiafeng Zhou, Ao Xiang, Ao Xiang, Yaqi Zeng, Yaqi Zeng, Jing Luo, Jing Luo, Bojie Zhou, Bojie Zhou, Nana Guo, Nana Guo, Xuhui Zhou   +14 more
doaj   +1 more source

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet, Iain K. Robertson, Sharon P. Luccisano, Michelle L. Kilpatrick   +3 more
wiley   +1 more source

Association of perioperative initiation of gabapentin versus pregabalin with kidney function: a target trial emulation study

Frontiers in Medicine
BackgroundGabapentinoids, such as gabapentin and pregabalin, are opioid substitutes commonly included in perioperative multimodal analgesia regimens. We investigated whether the initiation of gabapentin and pregabalin during the perioperative period have
Yanfang He, Liqian Mo, Juan Li, Dongying Lu, Jinlei Niu, Ying Li, Qiying Zeng, Yueming Gao   +7 more
doaj   +1 more source