Results 141 to 150 of about 31,350 (256)

Family History of Chronic Pain: What Impact Does It Have on Current Clinical Status? Results From an Italian Study

European Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Although a key factor in understanding intergenerational transmission, family history of chronic pain deserves greater attention, particularly about its role as a potential mediating factor on current psychophysical status, together with other underestimated parameters (e.g., psychiatric comorbidity).
Simona Pupo, Camilla Barbi, Marika Alessia Incardona, Giovanni Musetti, Marco Menchetti, Lorenzo Pelizza   +5 more
wiley   +1 more source

Perioperative pregabalin does not alter behavioural or diffuse noxious inhibitory control responses in 2 rat models of chronic pain. [PDF]

Pain Rep
Di Domenico F, Kucharczyk MW, Patel R, Bannister K.   +3 more
europepmc   +1 more source

Prevalence and Predictors of Substance Use Disorder Due to Gabapentinoids in Patients With Chronic Non‐Cancer Pain: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims The increase in the use of gabapentinoids in the treatment of patients with chronic non‐cancer pain (CNCP) has drawn attention to the possibility of substance use disorder (SUD) due to gabapentinoids. Systematic literature reviews have provided evidence of the risk of SUD due to gabapentinoids within substance‐using ...
Neele Kufeld, Klaus Weckbecker, Eva Münster, Norbert Scherbaum, Michael Specka, Johannes Just   +5 more
wiley   +1 more source

Effect of Erector Spinae Plane Block Applied to Painful Herpes Zoster Patients Who Failed to Respond to Pregabalin Treatment on Immunological Marker Levels and Postherpetic Neuralgia Incidence Rate. [PDF]

J Pain Res
Büyükbezirci G, Demiralp N, Keles S, Yılmaz R, Arıcan Ş, Tuncer Uzun S, Reisli R, Reisli İ.   +7 more
europepmc   +1 more source

Safety, Tolerability, and Pharmacokinetics of Oral Camlipixant: A Randomized First‐In‐Human Study Using Single and Multiple Ascending Doses

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Camlipixant is a highly selective P2X3 receptor antagonist with demonstrated efficacy in pre‐clinical models of evoked cough. We report the safety, tolerability, and pharmacokinetics of camlipixant in healthy participants. This Phase 1, double‐blind, randomized study evaluated single ascending doses (SAD; 50/100/200/400/800/1200 mg) and ...
Nathalie Chauret, Denis Garceau, Laurent Harvey, Zelie Bailes, Elizabeth A. Duncan, Rhian McNaughton, Miren Zamacona   +6 more
wiley   +1 more source

Patterns of pregabalin misuse: Need for intervention. [PDF]

Indian J Med Res
Sarvepalli T, Mewada S, Shukla S, Kalaiselvan V.   +3 more
europepmc   +1 more source

Ultrasound‐Guided Liposomal vs. Conventional Bupivacaine Erector Spinae Plane Block Plus Gabapentin for Postherpetic Neuralgia

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT This study aimed to compare efficacy and safety of ultrasound‐guided erector spinae plane block (ESPB) using liposomal (LB) versus conventional bupivacaine (CB), each plus standardized gabapentin, in patients with postherpetic neuralgia (PHN). A total of 116 PHN patients were randomized to ESPB‐LB or ESPB‐CB; both groups received standardized ...
Xia‐Jing Xu, Li‐Juan Liu, Fa‐Ming Xu, Xiang‐Yu Fang   +3 more
wiley   +1 more source

Utilization of adjunctive anti-seizure medications to facilitate chronic benzodiazepine discontinuation. [PDF]

Ment Health Clin
Dueno MR, Howington GT, Ryan M.
europepmc   +1 more source

A Systematic Review of Published Physiologically Based Pharmacokinetic Models for Drug Excretion Into Human Breastmilk: Knowledge Gaps and Opportunities to Optimize Reporting and Modeling Practices

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to predict infant exposure to medications via breast milk. Existing guidance on reporting of PBPK modeling analyses is unstructured and nonbinding to researchers. We evaluated reporting practices and modeling approaches in published PBPK modeling studies.
Joshua Kiptoo, Davies Otieno, Kenta Yoshida, Neel Deferm, Aida Nakayiwa Kawuma, Francis Williams Ojara, Adeniyi Olagunju, Jackson K. Mukonzo, Catriona Waitt   +8 more
wiley   +1 more source

Revisiting Controversial Areas in the Management of Premature Ejaculation

Trends in Urology &Men's Health, Volume 17, Issue 4, August 2026.
ABSTRACT The cause of premature ejaculation (PE) is often multifactorial in nature, and effective management of PE is complex and should involve multimodal approaches. This narrative review examines the ongoing controversies surrounding key areas in the diagnosis and treatment of PE with an emphasis on future research directions to align clinical care ...
Dong Sup Lee, Min Gu Park, Sun Tae Ahn, Ho Seok Chung, Hwancheol Son, Hyun Jun Park, Eric Chung   +6 more
wiley   +1 more source