Results 1 to 10 of about 235,181 (316)

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]

, 2008
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Anja Rode, Baes, Bauer, Branko Zevnik, C. Roland Wolf, Dotzlaw, Forrester, Hustert, Jillian Ross, Kocarek, Lowry, Lukas, Meehan, Nico Scheer, Nicole Faust, Poland, Sandra Niehaves, Smith, Wolf, Wrighton   +19 more
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The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. [PDF]

, 2010
The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic detoxification.
Damjanov, Ivan, Wan, Yu-Jui Yvonne, Wang, Kun   +2 more
core   +4 more sources

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells [PDF]

, 2013
The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined.
A Moreau, B Zhang, BA Laffitte, Bingfang Hu, C Handschin, DJ Peet, EA Podrez, G Liang, GD Barish, H Shimano, HJ Kim, J Berger, J Zhou, J Zhou, JJ Repa, JJ Repa, JM Ntambi, JM Ntambi, JM Peters, JR Schultz, Jun Zhang, K Chu, K Nakamura, M Febbraio, M Miyazaki, Makoto Makishima, MC Sugden, Min Huang, O Gavrilova, P Georgel, P Tontonoz, S Kersten, S Yu, SB Joseph, SP Saini, W Jiang, W Samuel, W Xie, Wen Xie, X Feng, Y Barak, Y Zhai, Y Zhang, Yijuan Wei, Yonggong Zhai, YX Wang   +45 more
core   +9 more sources

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
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Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in earlyand late-stage cholestasis [PDF]

, 2017
AIM: To ascertain whether cholestasis affects the expression of two CYP3A isoforms (CYP3A1 and CYP3A2) and of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Albertoni, Laura, Baldo, Vincenzo, Baldovin, Tatjana, Carrara, Maria, DALLA POZZA, Arianna, De Martin, Sara, Floreani, Annarosa, Gabbia, Daniela, Lazzari, Roberta, Zigiotto, Giorgia   +9 more
core   +1 more source

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. [PDF]

, 2008
The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification.
Finn, Robert, Henderson, Colin, Scott, Claire, Wolf, Roland   +3 more
core   +4 more sources

Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features [PDF]

, 2015
Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of ...
Bergamasco B, Bordi G, Busani L, Caserta D, Ciardo F, Focardi S, Guerranti C, La Rocca C, Mancini FR, Mantovani A, Marci R, Moscarini M, Perra G, Stecca L, Tait S   +14 more
core   +2 more sources

Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms [PDF]

, 2012
BACKGROUND AND PURPOSE Widespread resistance to antimalarial drugs requires combination therapies with increasing risk of pharmacokinetic drugdrug interactions.
Alexander, Arnold, Asimus, Auerbach, Auerbach, Baes, Berman, Blättler, Burk, Burk, di Masi, Dring, Elsherbiny, Faucette, Gautam, Giao, Grace, Halgren, Hesse, Hoffart, Honda, Huey, Hustert, Jyrkkärinne, Kawamoto, Kerb, Khoo, Krey, Kyle, Lee, Maglich, Moore, Morris, Navaratnam, Nussler, Pan, Pissios, Ross, Sanner, Simonsson, Skinner-Adams, Svensson, Svärd, Wang, Ward, White, WHO, WHO, Windshügel, Wolbold, Xu, Zhang   +51 more
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The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat [PDF]

, 2010
The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed.
Anna-Lena Ungell, Bauer, Britt-Marie Fihn, Constanze Hilgendorf, Englund, Harrison, Iain S. Haslam, Johan E. Karlsson, Lam, Nicholas L. Simmons, Noe, Read, Simon Lowes   +12 more
core   +2 more sources

A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines [PDF]

, 2018
Background: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite ...
A Boldyrev, A Leibowitz, AA Ferrando, AA Smith, B Lecka-Czernik, C Fasolato, C Harteneck, C Morris, CL Hoppel, D Belelli, D Fietz, E Asmussen, E Chorell, E Pohjanen, G Lac, G Van Hall, GC Bogdanis, GD Lewis, GJ Rietjens, H Budde, H Budde, H Karlic, H Yokoyama, J Henriksson, JB Walker, JH Mitchell, JK Nicholson, JM Peake, JS Fuqua, K Goto, K Sahlin, K Sahlin, K Sato, K Sato, KR Howarth, LS Eriksson, ME Powers, MH Jacob, MH Williams, MJ Ormsbee, ML Circu, ML Goodwin, P Yin, PC Tullson, R Berton, RF Coburn, S Naz, SC Lu, SK Powers, TE Graham, W Dudzinska, YP Pitsiladis   +51 more
core   +1 more source