Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment [PDF]
Biomolecules, 2021 Pregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed in normal and malignant tissues. Drug metabolizing enzymes and transporters are
Aikaterini Skandalaki +2 more
doaj +3 more sources
The role of pregnane X receptor (PXR) in substance metabolism [PDF]
Frontiers in Endocrinology, 2022 As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is a ligand-activated transcription factor that plays a crucial role in the metabolism of xenobiotics and endobiotics in mammals.
Ye Lv +7 more
doaj +2 more sources
Targeting the pregnane X receptor using microbial metabolite mimicry [PDF]
EMBO Molecular Medicine, 2020 The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity.
Zdeněk Dvořák +41 more
doaj +4 more sources
The Interface between Cell Signaling Pathways and Pregnane X Receptor [PDF]
Cells, 2021 Highly expressed in the enterohepatic system, pregnane X receptor (PXR, NR1I2) is a well-characterized nuclear receptor (NR) that regulates the expression of genes in the liver and intestines that encode key drug metabolizing enzymes and drug transporter
Robert S. Rogers +14 more
doaj +2 more sources
Pregnane X Receptor‒4β‐Hydroxycholesterol Axis in the Regulation of Overweight‐ and Obesity‐Induced Hypertension [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Mechanisms mediating hypertensive effects of overweight and obesity have not been fully elucidated. We showed previously that activation of pregnane X receptor (PXR) by rifampicin elevates 24‐hour blood pressure (BP) and plasma 4β ...
Roosa Rahunen +6 more
doaj +2 more sources
Cannabidiol promotes intestinal cholesterol uptake mediated by Pregnane X receptor [PDF]
Frontiers in EndocrinologyBackgroundCannabidiol (CBD), a non-psychoactive phytocannabinoid of cannabis, is therapeutically used as an analgesic, anti-convulsant, anti-inflammatory, and anti-psychotic drug.
Conner Brown +4 more
doaj +2 more sources
Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor [PDF]
MoleculesOverdose intake of acetaminophen (APAP) causes liver injury involving hepatic drug metabolism and activation of oxidative stress pathways, and forsythiaside A (FA) has hepatoprotective pharmacological activity, but knowledge of the mechanism of FA ...
Sisi Pu +6 more
doaj +2 more sources
Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor [PDF]
Frontiers in ImmunologyThe pregnane X receptor (PXR), a key hepatic nuclear receptor, exhibits a highly plastic ligand-binding domain (LBD) that recognizes diverse endogenous and exogenous ligands, contributing to interindividual variations in xenobiotic metabolism and toxic ...
Tong Lin +5 more
doaj +2 more sources
Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia. [PDF]
Arch Toxicol, 2023 AbstractPharmaceuticals and environmental contaminants contribute to hypercholesterolemia. Several chemicals known to cause hypercholesterolemia, activate pregnane X receptor (PXR). PXR is a nuclear receptor, classically identified as a sensor of chemical environment and regulator of detoxification processes.
Itkonen A, Hakkola J, Rysä J.
europepmc +4 more sources
Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform [PDF]
Frontiers in PharmacologyPregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy ...
Caitlin Lynch +8 more
doaj +2 more sources