The phenolic complex in flaxseed [PDF]
, 2008 Flaxseed is the richest plant source of the lignan secoisolariciresinol diglucoside (SDG). In flaxseed, SDG exists in an oligomeric structure with 3-hydroxy-3-methyl glutaric acid (HMGA) forming a phenolic complex together with p-coumaric acid and ...
Strandås, Christina
core
High Definition Immunoassays (HDIA) with Spatially Resolved Detection [PDF]
, 2012 Dealing with problem-solving has been a growing challenge in teaching engineering and over the career of these professionals. To increase the ability to understand a problem and consequently improve the quality of the solutions, an exercise was proposed ...
Ruan, Qiaoqiao +2 more
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PXR-mediated Metabolism During Pregnancy and Cholestasis
, 2009 Nuclear receptors, including the pregnane x receptor (PXR) and the farnesoid x receptor (FXR), regulate the expression of genes that maintain bile acid (BA) homeostasis. Intrahepatic cholestasis of pregnancy (ICP) is a common gestational liver disease
Owen, Bryn Myers, Owen, Bryn Myers
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Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature [PDF]
, 2021 Sarah Kim +7 more
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Pregnane X Receptor and Cancer: Context-Specificity is Key
Nuclear Receptor Research, 2016 Pregnane X receptor (PXR) is an adopted orphan nuclear receptor that is activated by a wide-range of endobiotics and xenobiotics, including chemotherapy drugs. PXR plays a major role in the metabolism and clearance of xenobiotics and endobiotics in liver and intestine via induction of drug-metabolizing enzymes and drug-transporting proteins.
Satyanarayana R, Pondugula +2 more
openaire +2 more sources
The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor [PDF]
, 2020 Nicolas Creusot +14 more
openalex +1 more source
Pregnane X Receptor Protects HepG2 Cells from BaP-Induced DNA Damage [PDF]
, 2008 Christine Naspinski +5 more
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Chronic Exposure to Rifaximin Causes Hepatic Steatosis in Pregnane X Receptor-Humanized Mice [PDF]
, 2012 Jie Cheng +3 more
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PLoS ONE, 2019 BACKGROUND:The Pregnane X Receptor (PXR) is a principal signal transducer in mucosal responses to xenobiotic stress. It is well-recognized that inflammatory bowel disease is accompanied by xenobiotic stress, but the importance of the PXR in limiting ...
J Jasper Deuring +7 more
doaj +1 more source
Alterations of Histone Modifications Contribute to Pregnane X Receptor-Mediated Induction of CYP3A4 by Rifampicin [PDF]
, 2017 Yan Liang +6 more
openalex +1 more source