Results 121 to 130 of about 102,002 (183)

Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction. [PDF]

ACS Med Chem Lett, 2021
Ramanjulu JM, Williams SP, Lakdawala AS, DeMartino MP, Lan Y, Marquis RW.   +5 more
europepmc   +1 more source

A Combined Approach for Rapid Dereplication of Herb-Drug Interaction Causative Agents in Botanical Extracts-A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe. [PDF]

ACS Omega
Annam SCVAR, Neal WM, Pandey P, Avula B, Katragunta K, Husain I, Khan SI, Koturbash I, Gurley BJ, Khan IA, Chittiboyina AG.   +10 more
europepmc   +1 more source

St. John's Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism. [PDF]

FASEB J, 2021
Yan T, Luo Y, Xia Y, Hamada K, Wang Q, Yan N, Krausz KW, Ward JM, Hao H, Wang P, Gonzalez FJ.   +10 more
europepmc   +1 more source

Pregnane X Receptor Signaling Pathway and Vitamin K: Molecular Mechanisms and Clinical Relevance in Human Health. [PDF]

Cells
Staudinger JL, Mahroke A, Patel G, Dattel C, Reddy S.   +4 more
europepmc   +1 more source

S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury. [PDF]

JCI Insight
Cui Q, Jiang T, Xie X, Wang H, Qian L, Cheng Y, Li Q, Lu T, Yao Q, Liu J, Lai B, Chen C, Xiao L, Wang N.   +13 more
europepmc   +1 more source

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library. [PDF]

Cells, 2022
Mustonen EK, Pantsar T, Rashidian A, Reiner J, Schwab M, Laufer S, Burk O.   +6 more
europepmc   +1 more source

Pregnane X receptor knockout mitigates weight gain and hepatic metabolic dysregulation in female C57BL/6 J mice on a long-term high-fat diet. [PDF]

Biomed Pharmacother
Gebreyesus LH, Choi S, Neequaye P, Mahmoud M, Mahmoud M, Ofosu-Boateng M, Twum E, Nnamani DO, Wang L, Yadak N, Ghosh S, Gonzalez FJ, Gyamfi MA.   +12 more
europepmc   +1 more source

Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor.

PLoS ONE, 2014
doaj   +3 more sources

Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor.

Drug Discovery Today, 2019
S. Chai, Wenwei Lin, Yongtao Li, Taosheng Chen   +3 more
semanticscholar   +1 more source

Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation

Journal of Pharmacology and Experimental Therapeutics, 2016
Aditya Garg, Angela Zhao, Sarah L. Erickson, Subhajit Mukherjee, A. Lau, L. Alston, Thomas K. H. Chang, S. Mani, S. Hirota   +8 more
semanticscholar   +1 more source