Results 131 to 140 of about 16,921 (212)

Pregnane X Receptor (PXR) modulates NLRP3 Inflammasome

, 2017
Compounds released from the intestinal microbiota may play a role in maintaining mucosal homeostasis, but little is known about the receptors that sense and respond to these compounds. Recently, a cytosolic xenobiotic sensor, the pregnane X receptor (PXR), was identified as a receptor for microbial metabolites in the gastrointestinal (GI) tract.
openaire   +2 more sources

Screening Method for the Identification of Compounds That Activate Pregnane X Receptor. [PDF]

Curr Protoc, 2022
Lynch C, Sakamuru S, Xia M.
europepmc   +1 more source

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice. [PDF]

Mol Metab, 2023
Karpale M, Kummu O, Kärkkäinen O, Lehtonen M, Näpänkangas J, Herfurth UM, Braeuning A, Rysä J, Hakkola J.   +8 more
europepmc   +1 more source

QSAR development and profiling of 72,524 REACH substances for PXR activation and CYP3A4 induction [PDF]

, 2017
Abildgaard Rosenberg, Sine, Dybdahl, Marianne, Huang, R., Nikolov, Nikolai Georgiev, Wedebye, Eva Bay, Xia, M.   +5 more
core   +1 more source

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation. [PDF]

Acta Pharm Sin B, 2023
Florke Gee RR, Huber AD, Wu J, Bajpai R, Loughran AJ, Pruett-Miller SM, Chen T.   +6 more
europepmc   +1 more source

Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators. [PDF]

Structure
Huber AD, Garcia-Maldonado E, Lin W, Poudel S, Wu J, Miller DJ, Chen T.   +6 more
europepmc   +1 more source

Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway. [PDF]

CNS Neurosci Ther, 2023
Xuan LN, Hu ZX, Jiang ZF, Zhang C, Sun XW, Ming WH, Liu HT, Qiao RF, Shen LJ, Liu SB, Wang GY, Wen L, Luan ZL, Yin J.   +13 more
europepmc   +1 more source

Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis. [PDF]

Front Pharmacol
Rao S, Mei Y, Shi L, Li H, Zhou M, Meng Z, Zhao Z, Li S, Sun W, Tian Q.   +9 more
europepmc   +1 more source

Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor. [PDF]

PLoS ONE, 2016
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel   +6 more
doaj   +1 more source

Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions. [PDF]

Nat Commun, 2023
Fan S, Yan Y, Xia Y, Zhou Z, Luo L, Zhu M, Han Y, Yao D, Zhang L, Fang M, Peng L, Yu J, Liu Y, Gao X, Guan H, Li H, Wang C, Wu X, Zhu H, Cao Y, Huang C.   +20 more
europepmc   +1 more source