Results 131 to 140 of about 16,876 (211)

Pregnane X Receptor (PXR) modulates NLRP3 Inflammasome

, 2017
Compounds released from the intestinal microbiota may play a role in maintaining mucosal homeostasis, but little is known about the receptors that sense and respond to these compounds. Recently, a cytosolic xenobiotic sensor, the pregnane X receptor (PXR), was identified as a receptor for microbial metabolites in the gastrointestinal (GI) tract.
openaire   +2 more sources

Advances in drug resistance of triple negative breast cancer caused by pregnane X receptor. [PDF]

World J Clin Oncol, 2023
Rao ZZ, Tang ZW, Wen J.
europepmc   +1 more source

Protocatechuic acid inhibits LPS-induced mastitis in mice through activating the pregnane X receptor. [PDF]

J Cell Mol Med, 2023
Zhao L, Jin L, Yang B.
europepmc   +1 more source

Screening Method for the Identification of Compounds That Activate Pregnane X Receptor. [PDF]

Curr Protoc, 2022
Lynch C, Sakamuru S, Xia M.
europepmc   +1 more source

Pregnane X receptor mitigates aristolochic acid-induced acute kidney injury via p53 ubiquitination. [PDF]

Ren Fail
Liu Q, Deng F, Chen A, Liu Y.
europepmc   +1 more source

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice. [PDF]

Mol Metab, 2023
Karpale M, Kummu O, Kärkkäinen O, Lehtonen M, Näpänkangas J, Herfurth UM, Braeuning A, Rysä J, Hakkola J.   +8 more
europepmc   +1 more source

Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor. [PDF]

PLoS ONE, 2016
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel   +6 more
doaj   +1 more source

Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators. [PDF]

Structure
Huber AD, Garcia-Maldonado E, Lin W, Poudel S, Wu J, Miller DJ, Chen T.   +6 more
europepmc   +1 more source

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation. [PDF]

Acta Pharm Sin B, 2023
Florke Gee RR, Huber AD, Wu J, Bajpai R, Loughran AJ, Pruett-Miller SM, Chen T.   +6 more
europepmc   +1 more source

Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis. [PDF]

Front Pharmacol
Rao S, Mei Y, Shi L, Li H, Zhou M, Meng Z, Zhao Z, Li S, Sun W, Tian Q.   +9 more
europepmc   +1 more source