Results 131 to 140 of about 235,181 (316)
Cancer Reports, Volume 8, Issue 5, May 2025.ABSTRACT Background Globally, infections account for 10% of new cancer cases, and cancer can compromise the immune system, increasing the risk of infections. With advances in cancer treatment, widespread use of immunotherapy, and prolonged survival of cancer patients, the coexistence of tuberculosis (TB) and cancer is becoming increasingly common in ...
Wendi Zhou +7 more
wiley +1 more source
Endocrine Disrupting Chemicals, Phthalic Acid and Nonylphenol, Activate Pregnane X Receptor-Mediated Transcription [PDF]
, 2000 Hisashi Masuyama +4 more
openalex +2 more sources
Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor [PDF]
, 2014 Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution.
Celander, Malin C. +11 more
core +1 more source
An Update on the Nutritional and Therapeutic Potential of Dioscorea oppositifolia
Food Science &Nutrition, Volume 13, Issue 5, May 2025.Dioscorea oppositifolia L. (Cinnamon vine) contains bioactive compounds, such as diosgenin, demonstrating anticancer properties. Diosgenin inhibits JAK/STAT3 signaling, suppressing cell proliferation, invasion and metastasis. Additionally, it triggers mitochondrial apoptosis by activating Bax, promoting cytochrome C release and stimulating caspase‐9 ...
Ruchika Kumari +10 more
wiley +1 more source
Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor [PDF]
Experimental Dermatology, 2015 AbstractSkin is in daily contact with potentially harmful molecules from the environment such as cigarette smoke, automobile emissions, industrial soot and groundwater. Pregnane X receptor (PXR) is a transcription factor expressed in liver and intestine that is activated by xenobiotic chemicals including drugs and environmental pollutants.
Matthias Schmuth +6 more
openaire +2 more sources
Frontiers in Pharmacology, 2016 Pregnane X receptor is a ligand-activated nuclear receptor (NR) that mainly controls inducible expression of xenobiotics handling genes including biotransformation enzymes and drug transporters.
P. Pávek
semanticscholar +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.USP13 is a promising therapeutic target for cellular proliferation in multiple myeloma. Bruceine A can retard the development of multiple myeloma by targeting USP13/PARP1‐mediated DNA damage repair and triggering cell apoptosis. ABSTRACT Multiple myeloma (MM) is an incurable hematologic malignancy, driving significant interest in the discovery of novel
Mengjie Guo +9 more
wiley +1 more source
The Nuclear Pregnane X Receptor Regulates Xenobiotic Detoxification [PDF]
The Journal of Nutrition, 2003 The pregnane X receptor (PXR), which is a member of the nuclear receptor family of ligand-activated transcription factors, is an integral component of the body's defense mechanism against toxic xenobiotics. PXR is activated by a broad spectrum of lipophilic xenobiotics including prescription drugs, herbs, pesticides, endocrine disruptors and other ...
openaire +3 more sources
Structure and dynamics of dynorphin peptide and its receptor [PDF]
arXiv, 2019 Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv
The pregnane xenobiotic receptor, a prominent liver factor, has actions in the midbrain for neurosteroid synthesis and behavioral/neural plasticity of female rats [PDF]
, 2014 A novel factor of interest for growth/plasticity in the brain is pregnane xenobiotic receptor (PXR). PXR is a liver factor known for its role in xenobiotic clearance and cholesterol metabolism.
Alicia A. Walf +2 more
core +1 more source