Results 141 to 150 of about 16,921 (212)

Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse. [PDF]

Oncogenesis
Bansard L, Laconde G, Delfosse V, Huet T, Ayeul M, Rigal E, Donati Q, Gerbal-Chaloin S, Daujat-Chavanieu M, Brunel L, Legrand B, Chavanieu A, Martin AR, Pannequin J, Bourguet W, Amblard M, Pascussi JM.   +16 more
europepmc   +1 more source

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam [PDF]

, 2018
Akk, Gustav, Cao, Lily Q, Chakrabarti, Shampuma, Evers, Alex S, Germann, Allison L, Mennerick, Steven, Montana, Michael C, Shin, Daniel J, Wozniak, David F, Yuede, Carla M   +9 more
core   +1 more source

Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis. [PDF]

Cell Death Discov
Li S, Xu Y, Xu W, Zhang D, Lin X, Hu P, Si H.   +6 more
europepmc   +1 more source

Expression and Prognostic Implication of the Nuclear Receptors Farnesoid X Receptor and Pregnane X Receptor in Human Cholangiocarcinoma. [PDF]

Cancer Diagn Progn
Sa-Ngiamwibool P, Yoshinari K, Shizu R, Kongpetch S, Prawan A, Senggunprai L.   +5 more
europepmc   +1 more source

Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling. [PDF]

iScience, 2023
Chen Y, Cui T, Xiao S, Li T, Zhong Y, Tang K, Guo J, Huang S, Chen J, Li J, Wang Q, Huang J, Pan H, Gao Y.   +13 more
europepmc   +1 more source

Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling. [PDF]

Acta Pharmacol Sin, 2023
Ming WH, Luan ZL, Yao Y, Liu HC, Hu SY, Du CX, Zhang C, Zhao YH, Huang YZ, Sun XW, Qiao RF, Xu H, Guan YF, Zhang XY.   +13 more
europepmc   +1 more source

Blockade of the estrogen receptor alpha-pregnane X receptor axis protects ovariectomized mice against ethanol-induced hepatotoxicity. [PDF]

J Biol Chem
Twum E, Ofosu-Boateng M, Nnamani DO, Gebreyesus LH, Yadak N, Kharbanda KK, Gonzalez FJ, Gyamfi MA.   +7 more
europepmc   +1 more source

Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation. [PDF]

Sci Rep
Hu WJ, Liu M, Bao YN, Su BW, Sui X, Cui XH, Wang GY, Wen L, Wen RK, Wang WH, Yang HX, Luan ZL.   +11 more
europepmc   +1 more source

Pregnane X Receptor and the Gut-Liver Axis: A Recent Update. [PDF]

Drug Metab Dispos, 2022
Dutta M, Lim JJ, Cui JY.
europepmc   +1 more source

Quantifying expression and metabolic activity of genes regulated by pregnane X receptor in primary human hepatocyte spheroids. [PDF]

PLoS Comput Biol
Lochman L, Kahiya ET, Saade B, Smutný T, Tebbens JD, Pávek P, Bernhauerová V.   +6 more
europepmc   +1 more source