Results 141 to 150 of about 235,181 (316)

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source

Protein connectivity in chemotaxis receptor complexes [PDF]

, 2015
The chemotaxis sensory system allows bacteria such as Escherichia coli to swim towards nutrients and away from repellents. The underlying pathway is remarkably sensitive in detecting chemical gradients over a wide range of ambient concentrations. Interactions among receptors, which are predominantly clustered at the cell poles, are crucial to this ...
arxiv   +1 more source

Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium‐induced colitis in mice

British Journal of Pharmacology, 2018
Activation of the human pregnane X receptor (PXR; NR1I2) has potential therapeutic uses for inflammatory bowel disease (IBD). Imperatorin (IMP), a naturally occurring coumarin, is the main bioactive ingredient of Angelica dahurica Radix, which is ...
Meijing Liu, Guohui Zhang, Chunge Zheng, Meng Song, Fangle Liu, Xiaotao Huang, Shasha Bai, Xinan Huang, Chaozhan Lin, Chenchen Zhu, Ying-Jie Hu, Sui-qing Mi, Changhui Liu   +12 more
semanticscholar   +1 more source

Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development. [PDF]

, 2012
Vitamin K (VK) is a liposoluble vitamin known to be essential for bone metabolism by two different pathways: (i) by its role as a coenzyme in the gamma-carboxylation of some skeletal proteins (e.g.
Cancela, Leonor, Fernández, Ignacio, Gavaia, Paulo J.   +2 more
core  

Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain [PDF]

, 2005
Steroids in the brain arise both from local synthesis and from peripheral sources and have a variety of effects on neuronal function. However, there is little direct chemical evidence for the range of steroids present in brain or of the pathways for ...
Corol, DI, Ebner, MJ, Fry, JP, Havlikova, H, Honour, JW   +4 more
core   +1 more source

Increased risk of osteoporotic fractures and osteoporosis in patients with Addison's disease in Sweden: A nationwide population‐based cohort study

Journal of Internal Medicine, Volume 297, Issue 5, Page 518-531, May 2025.
Abstract Background The risk of major osteoporotic fractures (MOFs) and osteoporosis in patients with autoimmune Addison's disease (AAD) is unclear. Objective To investigate the risk of MOF in patients with AAD and the possible correlation with adrenal hormone replacement doses.
Stavros Stergianos, Tim Spelman, Daniel Eriksson, Sara Öster, Sigridur Björnsdottir, Olle Kämpe, Jakob Skov, Sophie Bensing   +7 more
wiley   +1 more source

Biology of PXR [PDF]

, 2014
Hormonal homeostasis is essential for a variety of physiological and pathological processes. Elimination and detoxification of xenobiotics, such as drugs introduced into the human body, could disrupt the balance of hormones due to the induction of drug ...
Dai, Shu, Guo, Yan, Wang, Jing, Xie, Wen, Zhai, Yonggong   +4 more
core  

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken [PDF]

, 2018
Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear ...
A Pedretti, AM Haritova, C Issa, CH Nightingale, D Carvalho, D Osguthorpe, D Sadowski, E Abu-Basha, E Chieli, H Elsheikh, J Dupuy, J Formica, J Sugatani, J Yang, JS Choi, JS Choi, K Lohner, K Yamaoka, KJ Livak, L Gibellini, L Li, LR Fortunato, M Goliomytis, M Guo, M Guo, M Nair, MD Hanwell, MM Pulido, MP Nair, MR Durk, O Trott, P Zakeri-Milani, P Zakeri-Milani, PV Balimane, R Walker, S Borska, S Kim, S Wang, SL Hsiu, T Guo, T Guo, TT Cushnie, V Madgula, W Li, X Liu, Y Hee Choi, YJ Chae, YQ Shan, Z Chen   +48 more
core   +2 more sources

Specific effects on liver relevant for performing a dietary cumulative risk assessment of pesticide residues

EFSA Journal, Volume 23, Issue 5, May 2025.
Abstract According to the ‘EFSA‐SANTE Action Plan on Cumulative Risk Assessment for pesticides residues’, EFSA initiated a retrospective cumulative risk assessment (CRA) of the effects of pesticide residues on the liver. For this CRA, EFSA identified the following liver‐specific effects in accordance with the International Harmonisation of Nomenclature
European Food Safety Authority (EFSA), Anna F. Castoldi, Tamara Coja, Anna Lanzoni, Kyriaki Machera, Luc Mohimont, Monica Nepal, Camilla Recordati, Federica Crivellente   +8 more
wiley   +1 more source

Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants

Experimental Biology and Medicine, 2010
The pregnane X receptor (PXR; NR1I2) and the farnesoid X receptor (FXR; NR1H4) regulate the expression of many major metabolic enzymes. With the pig being used as a model for humans in metabolic and toxicological studies and also an important food animal, we characterized the transactivation profile of the porcine orthologs of these receptors, pgPXR ...
Callie B. Pollock, Lawrence B. Schook, E. James Squires, Matthew A. Gray   +3 more
openaire   +3 more sources