Results 151 to 160 of about 235,181 (316)
Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor
Journal of Pharmacological Sciences, 2014 .: The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is activated by a number of clinically prescribed drugs and herbal extracts.
Rongrong Deng +10 more
doaj
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: Fibrosis is a common complication of inflammatory bowel diseases (IBDs). The pregnane X receptor (PXR) (encoded by NR1I2) suppresses intestinal inflammation and has been shown to influence liver fibrosis.
Kyle L. Flannigan +8 more
doaj
Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses [PDF]
Science's STKE (electronic resource) : signal transduction
knowledge environment 327 (21/03/2006) 13, 2007 Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this trafficking. However, membrane proteins also traffic through surface lateral diffusion in the plasma membrane. We describe
arxiv
International Journal of Molecular Sciences, 2018 The pregnane X receptor (PXR) is a drug/xenobiotic-activated transcription factor of crucial importance for major cytochrome P450 xenobiotic-metabolizing enzymes (CYP) expression and regulation in the liver and the intestine.
J. D. Tebbens +4 more
semanticscholar +1 more source
Meclizine is an agonist of human pregnane X receptor
The FASEB Journal, 2011 Pregnane X receptor (PXR) is a receptor that regulates the transcription of genes involved in various functions, including drug metabolism and transport. Conflicting data exist as to whether meclizine, which is a histamine H1 antagonist, is an activator of human PXR (hPXR).
Guixiang Yang +4 more
openaire +1 more source
Journal of Agricultural and Food Chemistry, 2018 Liver X receptor α (LXRα) controls important biological and pathophysiological processes such as lipid homeostasis. Inhibiting LXRα transactivation may beneficial in the treatment of nonalcoholic fatty liver disease (NAFLD), which is one of the main ...
Yen-Ning Lin +6 more
semanticscholar +1 more source
Rifaximin improves Clostridium difficile toxin A-induced toxicity in Caco-2 cells by the PXR-dependent TLR4/MyD88 /NF-?B pathway [PDF]
, 2016 Background: Clostridium difficile infections (CDIs) caused by Clostridium difficile toxin A (TcdA) lead to severe ulceration, inflammation and bleeding of the colon, and are difficult to treat.
BRUZZESE, EUGENIA +10 more
core +2 more sources
Drug Metabolism And Disposition, 2018 Altered expression of long noncoding RNAs (lncRNAs) by environmental chemicals modulates the expression of xenobiotic biotransformation-related genes and may serve as therapeutic targets and novel biomarkers of exposure.
Joseph L. Dempsey, J. Cui
semanticscholar +1 more source
Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]
, 2010 Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core +1 more source
Optimization of stress response through the nuclear receptor-mediated cortisol signalling network [PDF]
, 2013 It is an accepted paradigm that extended stress predisposes an individual to pathophysiology. However, the biological adaptations to minimize this risk are poorly understood. Using a computational model based upon realistic kinetic parameters we are able
A Madan +38 more
core +2 more sources