Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata [PDF]
Marine Drugs, 2016 A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the
Concetta Imperatore +7 more
doaj +3 more sources
Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]
, 2012 BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen +5 more
core +14 more sources
Activation of pregnane X receptor sensitizes alcoholic steatohepatitis by transactivating fatty acid binding protein 4. [PDF]
Acta Pharm Sin BZhang Y +14 more
europepmc +2 more sources
Role of pregnane X receptor in chemotherapeutic treatment [PDF]
Cancer Chemotherapy and Pharmacology, 2014 Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that differently expresses not only in human normal tissues but also in numerous types of human cancers. PXR can be activated by many endogenous substances and exogenous chemicals, and thus affects chemotherapeutic effects and intervenes drug-drug interactions by regulating its ...
Wei Zhuo +5 more
openalex +4 more sources
Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia. [PDF]
Arch Toxicol, 2023 AbstractPharmaceuticals and environmental contaminants contribute to hypercholesterolemia. Several chemicals known to cause hypercholesterolemia, activate pregnane X receptor (PXR). PXR is a nuclear receptor, classically identified as a sensor of chemical environment and regulator of detoxification processes.
Itkonen A, Hakkola J, Rysä J.
europepmc +4 more sources
Pregnane X Receptor Is a Target of Farnesoid X Receptor [PDF]
Journal of Biological Chemistry, 2006 The pregnane X receptor (PXR) is an essential component of the body's detoxification system. PXR is activated by a broad spectrum of xenobiotics and endobiotics, including bile acids and their precursors. Bile acids in high concentrations are toxic; therefore, their synthesis is tightly regulated by the farnesoid X receptor, and their catabolism ...
Diana, Jung +2 more
openaire +2 more sources
Cells, 2021 The pregnane X receptor (PXR, NR1I2) is a nuclear receptor which exerts its regulatory function by heterodimerization with the retinoid-X-receptor α (RXRα, NR2B1) and binding to the promoter and enhancer regions of diverse target genes.
Juan Pablo Rigalli +3 more
doaj +1 more source
Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier. [PDF]
Fluids Barriers CNSColón Ortiz R +9 more
europepmc +3 more sources
The pregnane X receptor in tuberculosis therapeutics [PDF]
Expert Opinion on Drug Metabolism & Toxicology, 2015 Among the infectious diseases, tuberculosis (TB) remains the second most common cause of death after HIV. TB treatment requires the combination of multiple drugs including the rifamycin class. However, rifamycins are activators of human pregnane X receptor (PXR), a transcription factor that regulates drug metabolism, drug resistance, energy metabolism ...
Amina I, Shehu +3 more
openaire +2 more sources
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]
, 2008 The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Anja Rode +19 more
core +4 more sources