Results 21 to 30 of about 235,181 (316)
Journal of Lipid Research, 2020 The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many
Yipeng Sui +7 more
doaj +2 more sources
Pregnane X receptor activation potentiates ritonavir hepatotoxicity [PDF]
Journal of Clinical Investigation, 2019 Ritonavir (RTV) is on the World Health Organization's List of Essential Medicines for antiretroviral therapy, but can cause hepatotoxicity by unknown mechanisms. Multiple clinical studies found that hepatotoxicity occurred in 100% of participants who were pretreated with rifampicin or efavirenz followed by RTV-containing regimens.
Amina I. Shehu +9 more
openaire +4 more sources
Post-translational Modification of Pregnane X Receptor [PDF]
Pharmacological Research, 2011 Pregnane x receptor (PXR, NR1I2) was originally characterized as a broad spectrum entero-hepatic xenobiotic ‘sensor’ and master-regulator of drug inducible gene expression.
Biswas, Arunima +3 more
core +5 more sources
PLoS ONE, 2019 BACKGROUND:The Pregnane X Receptor (PXR) is a principal signal transducer in mucosal responses to xenobiotic stress. It is well-recognized that inflammatory bowel disease is accompanied by xenobiotic stress, but the importance of the PXR in limiting ...
J Jasper Deuring +7 more
doaj +2 more sources
Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions. [PDF]
Nat Commun, 2023 Citrus fruit has long been considered a healthy food, but its role and detailed mechanism in lifespan extension are not clear. Here, by using the nematode C.
Fan S +20 more
europepmc +2 more sources
Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata [PDF]
Marine Drugs, 2016 A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the
Aiello, Anna +7 more
core +4 more sources
Pregnane X Receptor and Cancer: Context-Specificity is Key
Nuclear Receptor Research, 2016 Pregnane X receptor (PXR) is an adopted orphan nuclear receptor that is activated by a wide-range of endobiotics and xenobiotics, including chemotherapy drugs. PXR plays a major role in the metabolism and clearance of xenobiotics and endobiotics in liver and intestine via induction of drug-metabolizing enzymes and drug-transporting proteins.
Satyanarayana R. Pondugula +2 more
openaire +4 more sources
The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis. [PDF]
Cell Mol Gastroenterol Hepatol, 2023 Flannigan KL +8 more
europepmc +2 more sources
Pregnane X Receptor and the Gut-Liver Axis: A Recent Update. [PDF]
Drug Metab Dispos, 2022 It is well-known that the pregnane X receptor (PXR)/Nr1i2 is a critical xenobiotic-sensing nuclear receptor enriched in liver and intestine and is responsible for drug-drug interactions, due to its versatile ligand binding domain (LBD) and target genes ...
Dutta M, Lim JJ, Cui JY.
europepmc +2 more sources
The Interface between Cell Signaling Pathways and Pregnane X Receptor. [PDF]
Cells, 2021 Highly expressed in the enterohepatic system, pregnane X receptor (PXR, NR1I2) is a well-characterized nuclear receptor (NR) that regulates the expression of genes in the liver and intestines that encode key drug metabolizing enzymes and drug transporter
Rogers RS +14 more
europepmc +2 more sources