Results 41 to 50 of about 235,181 (316)

Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature.

Biochemical Pharmacology, 2021
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease due to the current epidemics of obesity and diabetes. The pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor known for trans-activating liver genes ...
S. Kim, Sora Choi, M. Dutta, M. Polunas, Michael J Goedken, F. Gonzalez, J. Cui, M. Gyamfi   +7 more
semanticscholar   +1 more source

The pregnane X receptor in tuberculosis therapeutics [PDF]

Expert Opinion on Drug Metabolism & Toxicology, 2015
Among the infectious diseases, tuberculosis (TB) remains the second most common cause of death after HIV. TB treatment requires the combination of multiple drugs including the rifamycin class. However, rifamycins are activators of human pregnane X receptor (PXR), a transcription factor that regulates drug metabolism, drug resistance, energy metabolism ...
Guangming Li, Wen Xie, Amina I. Shehu, Xiaochao Ma   +3 more
openaire   +3 more sources

Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice). [PDF]

Liver Res, 2022
Background and aims: The herbal supplement Gancao, also known as licorice, belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective effect. Recent studies have raised concerns about potential herb-drug interactions associated
Cheng A, Lei S, Zhu J, Lu J, Paine MF, Xie W, Ma X.   +6 more
europepmc   +2 more sources

Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning

Cells, 2021
The pregnane X receptor (PXR, NR1I2) is a nuclear receptor which exerts its regulatory function by heterodimerization with the retinoid-X-receptor α (RXRα, NR2B1) and binding to the promoter and enhancer regions of diverse target genes.
Juan Pablo Rigalli, Dirk Theile, Julie Nilles, Johanna Weiss   +3 more
doaj   +1 more source

Pregnane X Receptor Mediates Atherosclerosis Induced by Dicyclohexyl Phthalate in LDL Receptor-Deficient Mice. [PDF]

Cells, 2022
Plastic-associated endocrine disrupting chemicals (EDCs) have been implicated in the etiology of cardiovascular disease (CVD) in humans, but the underlying mechanisms remain elusive.
Liu J, Hernandez R, Li X, Meng Z, Chen H, Zhou C.   +5 more
europepmc   +2 more sources

Pregnane X receptor reduces particulate matter-induced type 17 inflammation in atopic dermatitis. [PDF]

Front Immunol
BackgroundEpidemiological evidence suggests that particulate matter (PM) exposure can trigger or worsen atopic dermatitis (AD); however, the underlying mechanisms remain unclear. Recently, pregnane X receptor (PXR), a xenobiotic receptor, was reported to
Lee JS, Lee Y, Jang S, Oh JH, Lee DH, Cho S.   +5 more
europepmc   +2 more sources

Targeting the pregnane X receptor in liver injury [PDF]

Expert Opinion on Therapeutic Targets, 2012
The nuclear receptor pregnane X receptor (PXR) is a well-characterized hepatic xenobiotic sensor whose activation by chemically diverse compounds results in the induction of drug clearance pathways that rid the body of potentially toxic substances, thus conferring protection from foreign chemicals and endobiotics.PXR activities are implicated in drug ...
Annette R. Atkins, Ronald M. Evans, Ruth T. Yu, Robert H. Tukey, Michael Downes, Tao Li   +5 more
openaire   +3 more sources

Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation.

PLoS ONE, 2015
Liver grafts donated after cardiac death are increasingly used to expand the donor pool but are prone to ischaemic-type biliary lesions. The anti-inflammatory effects of the activated pregnane X receptor have previously been shown to be beneficial in a ...
Aimen O Amer, Philip M Probert, Michael Dunn, Margaret Knight, Abigail E Vallance, Paul A Flecknell, Fiona Oakley, Iain Cameron, Steven A White, Peter G Blain, Matthew C Wright   +10 more
doaj   +1 more source

Role of pregnane X receptor in chemotherapeutic treatment [PDF]

Cancer Chemotherapy and Pharmacology, 2014
Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that differently expresses not only in human normal tissues but also in numerous types of human cancers. PXR can be activated by many endogenous substances and exogenous chemicals, and thus affects chemotherapeutic effects and intervenes drug-drug interactions by regulating its ...
Lei Hu, Jin-Feng Lv, Hong-Hao Zhou, Hongbing Wang, Lan Fan, Wei Zhuo   +5 more
openaire   +3 more sources

Modulation of T Lymphocyte Function by the Pregnane X Receptor [PDF]

The Journal of Immunology, 2010
Abstract The pregnane X receptor (PXR) is a ligand-activated transcription factor regulating genes central to drug and hormone metabolism in the liver. Previous reports indicated that PXR is expressed in PBMC, but the role of PXR in immune cells remains unknown.
Jutta Horejs-Hoeck, Matthias Schmuth, Sandrine Dubrac, Susanne Ebner, Andreas Elentner   +4 more
openaire   +3 more sources