Results 41 to 50 of about 16,876 (211)
Marine Ligands of the Pregnane X Receptor (PXR): An Overview
Marine Drugs, 2019 Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules. The receptor is able to regulate the expression of a wide array of genes and is involved in cancer and different key physiological ...
Alejandro Carazo +2 more
doaj +1 more source
Pregnane X receptor and drug-induced liver injury [PDF]
Expert Opinion on Drug Metabolism & Toxicology, 2014 The liver plays a central role in transforming and clearing foreign substances. The continuous exposure of the liver to xenobiotics sometimes leads to impaired liver function, referred to as drug-induced liver injury (DILI). The pregnane X receptor (PXR) tightly regulates the expression of genes in the hepatic drug-clearance system and its undesired ...
Yue-Ming, Wang +3 more
openaire +2 more sources
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: Fibrosis is a common complication of inflammatory bowel diseases (IBDs). The pregnane X receptor (PXR) (encoded by NR1I2) suppresses intestinal inflammation and has been shown to influence liver fibrosis.
Kyle L. Flannigan +8 more
doaj +1 more source
In vivo effect of dried chicory root (Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver [PDF]
, 2011 Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2,2Aand 2E1 are important for the metabolism of skatole.Feeding chicory roots to pigs is known to decrease the ...
Ekstrand, Bo +2 more
core +1 more source
Associations between Pregnane X Receptor and Breast Cancer Growth and Progression
Cells, 2020 Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is responsive to a broad array of both endobiotic and xenobiotic ligands.
Bradley A. Creamer +7 more
doaj +1 more source
Molecules, 2023 Compounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary to maintain the ...
Claudia Finamore +11 more
doaj +1 more source
SPA70 is a potent antagonist of human pregnane X receptor
Nature Communications, 2017 The xenobiotic-activated human pregnane X receptor (hPXR) regulates drug metabolism. Here the authors develop hPXR modulators, which are of potential therapeutic interest and functionally and structurally characterize the antagonist SPA70 and the ...
Wenwei Lin +9 more
doaj +1 more source
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]
, 2015 Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu +3 more
core +1 more source
Targeting the pregnane X receptor in liver injury [PDF]
Expert Opinion on Therapeutic Targets, 2012 The nuclear receptor pregnane X receptor (PXR) is a well-characterized hepatic xenobiotic sensor whose activation by chemically diverse compounds results in the induction of drug clearance pathways that rid the body of potentially toxic substances, thus conferring protection from foreign chemicals and endobiotics.PXR activities are implicated in drug ...
Tao, Li +5 more
openaire +2 more sources
Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor
Journal of Pharmacological Sciences, 2014 .: The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is activated by a number of clinically prescribed drugs and herbal extracts.
Rongrong Deng +10 more
doaj +1 more source