Results 61 to 70 of about 235,181 (316)
CYP3A4 and pregnane X receptor humanized mice [PDF]
Journal of Biochemical and Molecular Toxicology, 2007 AbstractMarked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450‐ and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (BAC) and P1 phage artificial chromosomes (PAC) genomic ...
openaire +3 more sources
Functional evolution of the vitamin D and pregnane X receptors [PDF]
BMC Evolutionary Biology, 2007 AbstractBackgroundThe vitamin D receptor (VDR) and pregnane X receptor (PXR) are nuclear hormone receptors of the NR1I subfamily that show contrasting patterns of cross-species variation. VDR and PXR are thought to have arisen from duplication of an ancestral gene, evident now as a single gene in the genome of the chordate invertebrateCiona ...
Lee R. Hagey +8 more
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Ligand-Receptor Interactions [PDF]
Reports on Progress in Physics 62 (1999) 921-968, 2008 The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last few years, three main lines of research led to a dramatic improvement of our understanding of these important phenomena.
arxiv +1 more source
Weak ergodicity breaking of receptor motion in living cells stemming from random diffusivity [PDF]
Phys. Rev. X 5, 011021 (2015), 2014 Molecular transport in living systems regulates numerous processes underlying biological function. Although many cellular components exhibit anomalous diffusion, only recently has the subdiffusive motion been associated with nonergodic behavior. These findings have stimulated new questions for their implications in statistical mechanics and cell ...
arxiv +1 more source
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2012 Purpose. Intestinal ischemia-reperfusion (I/R) damages remote organs, including the liver, and promotes multi-organ failure (MOF). However, the molecular mechanisms underlying acute liver injury after intestinal I/R have not been completely elucidated ...
Jiro Ogura +13 more
doaj +1 more source
Enhanced Acetaminophen Toxicity by Activation of the Pregnane X Receptor [PDF]
Toxicological Sciences, 2004 The pregnane X receptor (PXR) is a ligand-activated transcription factor and member of the nuclear receptor superfamily. Activation of PXR represents an important mechanism for the induction of cytochrome P450 3A (CYP3A) enzymes that can convert acetaminophen (APAP) to its toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI). Therefore,
Jeff S. Moffit +8 more
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Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.) [PDF]
, 2013 Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the ...
Ekstrand, Bo +2 more
core +1 more source
Pregnane X receptor and drug-induced liver injury [PDF]
Expert Opinion on Drug Metabolism & Toxicology, 2014 The liver plays a central role in transforming and clearing foreign substances. The continuous exposure of the liver to xenobiotics sometimes leads to impaired liver function, referred to as drug-induced liver injury (DILI). The pregnane X receptor (PXR) tightly regulates the expression of genes in the hepatic drug-clearance system and its undesired ...
Sergio C. Chai +3 more
openaire +3 more sources
PLoS ONE, 2014 The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics.
Marianne Mathäs +6 more
doaj +1 more source